FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911698052> ?p ?o ?g. }

• W2911698052 abstract "The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections. The increase in colistin usage has been mirrored by an increase in colistin resistance. We aimed to identify the mechanisms associated with colistin resistance in A. baumannii using multiple high-throughput-sequencing technologies, including transposon-directed insertion site sequencing (TraDIS), RNA sequencing (RNAseq) and whole-genome sequencing (WGS) to investigate the genotypic changes of colistin resistance in A. baumannii. Using TraDIS, we found that genes involved in drug efflux (adeIJK), and phospholipid (mlaC, mlaF and mlaD) and lipooligosaccharide synthesis (lpxC and lpsO) were required for survival in sub-inhibitory concentrations of colistin. Transcriptomic (RNAseq) analysis revealed that expression of genes encoding efflux proteins (adeI, adeC, emrB, mexB and macAB) was enhanced in in vitro generated colistin-resistant strains. WGS of these organisms identified disruptions in genes involved in lipid A (lpxC) and phospholipid synthesis (mlaA), and in the baeS/R two-component system (TCS). We additionally found that mutations in the pmrB TCS genes were the primary colistin-resistance-associated mechanisms in three Vietnamese clinical colistin-resistant A. baumannii strains. Our results outline the entire range of mechanisms employed in A. baumannii for resistance against colistin, including drug extrusion and the loss of lipid A moieties by gene disruption or modification." @default.
• W2911698052 created "2019-02-21" @default.
• W2911698052 creator A5000455663 @default.
• W2911698052 creator A5001836904 @default.
• W2911698052 creator A5002168518 @default.
• W2911698052 creator A5013471493 @default.
• W2911698052 creator A5016229356 @default.
• W2911698052 creator A5028534327 @default.
• W2911698052 creator A5031396231 @default.
• W2911698052 creator A5036777613 @default.
• W2911698052 creator A5046077459 @default.
• W2911698052 creator A5055156624 @default.
• W2911698052 creator A5065616918 @default.
• W2911698052 creator A5068258126 @default.
• W2911698052 creator A5069436379 @default.
• W2911698052 creator A5069769145 @default.
• W2911698052 creator A5075199232 @default.
• W2911698052 creator A5076264432 @default.
• W2911698052 creator A5083942740 @default.
• W2911698052 creator A5084268602 @default.
• W2911698052 date "2019-02-01" @default.
• W2911698052 modified "2023-10-02" @default.
• W2911698052 title "Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii" @default.
• W2911698052 cites W1575173606 @default.
• W2911698052 cites W1969589234 @default.
• W2911698052 cites W1972145956 @default.
• W2911698052 cites W1980030331 @default.
• W2911698052 cites W1986480819 @default.
• W2911698052 cites W1989733081 @default.
• W2911698052 cites W1989823376 @default.
• W2911698052 cites W1992500937 @default.
• W2911698052 cites W1992995635 @default.
• W2911698052 cites W2023469834 @default.
• W2911698052 cites W2032074894 @default.
• W2911698052 cites W2034337315 @default.
• W2911698052 cites W2036456340 @default.
• W2911698052 cites W2038188372 @default.
• W2911698052 cites W2047128135 @default.
• W2911698052 cites W2058710872 @default.
• W2911698052 cites W2065161622 @default.
• W2911698052 cites W2096093282 @default.
• W2911698052 cites W2098299258 @default.
• W2911698052 cites W2098885132 @default.
• W2911698052 cites W2103001238 @default.
• W2911698052 cites W2105838577 @default.
• W2911698052 cites W2110991941 @default.
• W2911698052 cites W2112586763 @default.
• W2911698052 cites W2113068511 @default.
• W2911698052 cites W2114104545 @default.
• W2911698052 cites W2115996594 @default.
• W2911698052 cites W2117795567 @default.
• W2911698052 cites W2123353572 @default.
• W2911698052 cites W2124996394 @default.
• W2911698052 cites W2125825231 @default.
• W2911698052 cites W2126504345 @default.
• W2911698052 cites W2126917641 @default.
• W2911698052 cites W2130440479 @default.
• W2911698052 cites W2132963724 @default.
• W2911698052 cites W2141119565 @default.
• W2911698052 cites W2152239989 @default.
• W2911698052 cites W2152744936 @default.
• W2911698052 cites W2157257457 @default.
• W2911698052 cites W2161069049 @default.
• W2911698052 cites W2164063484 @default.
• W2911698052 cites W2165464537 @default.
• W2911698052 cites W2168696662 @default.
• W2911698052 cites W2169916860 @default.
• W2911698052 cites W2171535756 @default.
• W2911698052 cites W2178527956 @default.
• W2911698052 cites W2190505876 @default.
• W2911698052 cites W2237100885 @default.
• W2911698052 cites W2281387347 @default.
• W2911698052 cites W2302435245 @default.
• W2911698052 cites W2310902680 @default.
• W2911698052 cites W2346538456 @default.
• W2911698052 cites W2403299959 @default.
• W2911698052 cites W2475041682 @default.
• W2911698052 cites W2517945749 @default.
• W2911698052 cites W2582987158 @default.
• W2911698052 cites W2588693877 @default.
• W2911698052 cites W2809749880 @default.
• W2911698052 cites W2949182334 @default.
• W2911698052 cites W4210557118 @default.
• W2911698052 doi "https://doi.org/10.1099/mgen.0.000246" @default.
• W2911698052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6421349" @default.
• W2911698052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720421" @default.
• W2911698052 hasPublicationYear "2019" @default.
• W2911698052 type Work @default.
• W2911698052 sameAs 2911698052 @default.
• W2911698052 citedByCount "26" @default.
• W2911698052 countsByYear W29116980522019 @default.
• W2911698052 countsByYear W29116980522020 @default.
• W2911698052 countsByYear W29116980522021 @default.
• W2911698052 countsByYear W29116980522022 @default.
• W2911698052 countsByYear W29116980522023 @default.
• W2911698052 crossrefType "journal-article" @default.
• W2911698052 hasAuthorship W2911698052A5000455663 @default.
• W2911698052 hasAuthorship W2911698052A5001836904 @default.
• W2911698052 hasAuthorship W2911698052A5002168518 @default.
• W2911698052 hasAuthorship W2911698052A5013471493 @default.

• next