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- W2911700180 endingPage "483" @default.
- W2911700180 startingPage "474" @default.
- W2911700180 abstract "Poor fitness among people with Multiple Sclerosis (MS) aggravates disease symptoms. Whether low fitness levels accompany brain functioning changes is unknown.MS patients (n = 82) completed a graded maximal exercise test, blood was drawn, and transcranial magnetic stimulation determined resting and active motor thresholds, motor evoked potential latency, and cortical silent period (CSP).Sixty-two percent of participants had fitness levels ranked below 10th percentile. Fitness was not associated with disability measured using the Expanded Disability Status Scale (EDSS). Regression analyses revealed that, cardiorespiratory fitness, when controlling for disease demographics, contributed 23.7% (p < 0.001) to the model explaining variance in CSP. Regression analysis using cardiorespiratory fitness and CSP as predictors showed that CSP alone explained 19.9% of variance in subjective fatigue (p = 0.002). Tumor necrosis factor was not associated with any variable.Low fitness was associated with longer CSP in MS. Longer CSP was, in turn, related to greater MS fatigue.MS patients had extremely low levels of cardiorespiratory fitness. Poor fitness predicted longer CSP, a marker of greater intracortical inhibition, which was linked to MS fatigue. Future research should examine whether aerobic training could shorten CSP and potentially lessen inhibition of cortical networks." @default.
- W2911700180 created "2019-02-21" @default.
- W2911700180 creator A5012819778 @default.
- W2911700180 creator A5016736065 @default.
- W2911700180 creator A5021135448 @default.
- W2911700180 creator A5071157557 @default.
- W2911700180 creator A5074684497 @default.
- W2911700180 date "2019-04-01" @default.
- W2911700180 modified "2023-09-26" @default.
- W2911700180 title "Prolonged cortical silent period is related to poor fitness and fatigue, but not tumor necrosis factor, in Multiple Sclerosis" @default.
- W2911700180 cites W1530424262 @default.
- W2911700180 cites W1750926410 @default.
- W2911700180 cites W1773319407 @default.
- W2911700180 cites W1787731127 @default.
- W2911700180 cites W1852401591 @default.
- W2911700180 cites W1904453581 @default.
- W2911700180 cites W1963809989 @default.
- W2911700180 cites W1966295254 @default.
- W2911700180 cites W1969666539 @default.
- W2911700180 cites W1970582608 @default.
- W2911700180 cites W1975255604 @default.
- W2911700180 cites W1984658195 @default.
- W2911700180 cites W1989296109 @default.
- W2911700180 cites W1991711453 @default.
- W2911700180 cites W1991952911 @default.
- W2911700180 cites W2003917631 @default.
- W2911700180 cites W2011136641 @default.
- W2911700180 cites W2012460194 @default.
- W2911700180 cites W2020745232 @default.
- W2911700180 cites W2020767502 @default.
- W2911700180 cites W2025420329 @default.
- W2911700180 cites W2027839244 @default.
- W2911700180 cites W2030216368 @default.
- W2911700180 cites W2030627876 @default.
- W2911700180 cites W2052676701 @default.
- W2911700180 cites W2053117941 @default.
- W2911700180 cites W2060928512 @default.
- W2911700180 cites W2063848046 @default.
- W2911700180 cites W2077730410 @default.
- W2911700180 cites W2078355922 @default.
- W2911700180 cites W2090428948 @default.
- W2911700180 cites W2101366597 @default.
- W2911700180 cites W2104087063 @default.
- W2911700180 cites W2108230902 @default.
- W2911700180 cites W2114101329 @default.
- W2911700180 cites W2128051944 @default.
- W2911700180 cites W2130836428 @default.
- W2911700180 cites W2134831005 @default.
- W2911700180 cites W2135311654 @default.
- W2911700180 cites W2139833228 @default.
- W2911700180 cites W2140097457 @default.
- W2911700180 cites W2140358254 @default.
- W2911700180 cites W2141317223 @default.
- W2911700180 cites W2141504417 @default.
- W2911700180 cites W2141796362 @default.
- W2911700180 cites W2143349681 @default.
- W2911700180 cites W2153084624 @default.
- W2911700180 cites W2156092714 @default.
- W2911700180 cites W2157979759 @default.
- W2911700180 cites W2159092433 @default.
- W2911700180 cites W2159476919 @default.
- W2911700180 cites W2164299118 @default.
- W2911700180 cites W2168901397 @default.
- W2911700180 cites W2199931105 @default.
- W2911700180 cites W2238244703 @default.
- W2911700180 cites W2250213961 @default.
- W2911700180 cites W2272799884 @default.
- W2911700180 cites W2286954903 @default.
- W2911700180 cites W2288937008 @default.
- W2911700180 cites W2336695325 @default.
- W2911700180 cites W2371547131 @default.
- W2911700180 cites W2417172500 @default.
- W2911700180 cites W2528794430 @default.
- W2911700180 cites W2560429321 @default.
- W2911700180 cites W2563476471 @default.
- W2911700180 cites W2591734839 @default.
- W2911700180 cites W2594378689 @default.
- W2911700180 cites W2597026225 @default.
- W2911700180 cites W2605804610 @default.
- W2911700180 cites W2607454372 @default.
- W2911700180 cites W2609861751 @default.
- W2911700180 cites W2617084495 @default.
- W2911700180 cites W2624771167 @default.
- W2911700180 cites W2625299651 @default.
- W2911700180 cites W2716827817 @default.
- W2911700180 cites W2734666522 @default.
- W2911700180 cites W2734705637 @default.
- W2911700180 cites W2739983728 @default.
- W2911700180 cites W2750840957 @default.
- W2911700180 cites W2754252849 @default.
- W2911700180 cites W2754427400 @default.
- W2911700180 cites W2755099150 @default.
- W2911700180 cites W2779968905 @default.
- W2911700180 cites W2780106115 @default.
- W2911700180 cites W2782077611 @default.
- W2911700180 cites W2782960599 @default.
- W2911700180 cites W2795785393 @default.
- W2911700180 cites W2803157285 @default.