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- W2911725889 abstract "Introduction: Patients with type-2 diabetes mellitus (T2DM) have high prevalence of nonalcoholic fatty liver disease (NAFLD) and are at higher risk of developing advanced disease defined as the presence of nonalcoholic steatohepatitis (NASH) and fibrosis. Previous research suggested an association between smoking and fibrosis (Zein et al. Hepatology). Aim of this study was to assess the potential association between smoking and advanced fibrosis in T2DM patients diagnosed with suspected NAFLD. Methods: Using ICD-9 codes, all adult patients with the diagnosis of T2DM were reviewed and a retrospective chart analysis was done. Patients with secondary causes of hepatic steatosis (excessive alcohol consumption, hepatitis C etc.) were excluded. Biopsy results were assessed for any evidence of fibrosis (Metavir F0- F4) in diagnosed NAFLD patients. Univariable and multivariable logistic regression analysis were performed to assess any association. Results: 1,157 subjects met the inclusion criteria of having T2DM and liver biopsy for suspected NAFLD. The mean age of these subjects was 51.1±11.5 years, 64.6% were males, 88.4 % were Caucasians, and 84.7 % were obese. The mean HbA1c was 6.7±1.5%, mean platelet count 217.6±83.0k and mean albumin level was 4.2±0.95g/dL. Liver biopsy showed 68.7% with no or early fibrosis (Metavir score 0-2) and 31.7% with advanced fibrosis (Metavir score 3-4). 58.9 % of patient with no or early fibrosis never smoked, 35.8% were former smoker, and 5.4% were current smokers. In patients with advanced fibrosis, 52.5% were non-smokers, 41.2 % were former smoker and 6.3 % were current smokers (p=0.12). Conclusion: Smoking is not associated with liver fibrosis in T2DM patients with biopsy proven NAFLD. Other co-morbidities and risk factors should be considered to find associations with fibrosis." @default.
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- W2911725889 date "2017-10-01" @default.
- W2911725889 modified "2023-10-18" @default.
- W2911725889 title "Association of Smoking With Advanced Fibrosis in Type 2 Diabetics With Suspected Non-Alcoholic Fatty Liver Disease" @default.
- W2911725889 doi "https://doi.org/10.14309/00000434-201710001-00998" @default.
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