Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911740147> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2911740147 abstract "The effect of prostaglandin E1 (PGE1) encapsulated in nanoparticles (Nano PGE1) on motor dysfunction and muscle atrophy induced by sciatic nerve injury (SNI) was investigated in rats, and was compared with PGE1 encapsulated in lipid microspheres (Lipo PGE1) or PGE1 clathrated in cyclodextrin (PGE1-CD). The hind limb muscle weight ratio decreased until 2 weeks after SNI. All 3 PGE1 formulations significantly improved SNI-induced motor dysfunction. Nano PGE1 significantly promoted recovery from muscle atrophy at 2 and 3 weeks after SNI. Lipo PGE1 was also effective, but multiple doses were required. Compared with the SNI control group, the Nano PGE1 group showed upregulation of vascular endothelial growth factor (VEGF) and agrin expression in the injured sciatic nerve and atrophic muscles. Nano PGE1 accumulated prominently at the site of nerve injury and persisted for longer than Lipo PGE1 or PGE1-CD. Expression of all EP receptors was detected in the normal sciatic nerve, and EP2 expression increased after SNI. Finally, Nano PGE1 promoted ERK1/2 and Akt phosphorylation. These findings suggest that PGE1 released from nanoparticles accumulates at sites of nerve injury and increases VEGF production by augmenting ERK1/2 phosphorylation via EP receptor signaling, thus promoting tissue repair and regeneration." @default.
- W2911740147 created "2019-02-21" @default.
- W2911740147 creator A5004738239 @default.
- W2911740147 creator A5006663167 @default.
- W2911740147 creator A5009633710 @default.
- W2911740147 creator A5016137949 @default.
- W2911740147 creator A5028583663 @default.
- W2911740147 creator A5033366805 @default.
- W2911740147 creator A5051583053 @default.
- W2911740147 creator A5055764710 @default.
- W2911740147 creator A5058452964 @default.
- W2911740147 date "2019-01-24" @default.
- W2911740147 modified "2023-09-24" @default.
- W2911740147 title "Nano PGE1 Enhances Phosphorylation of ERK1/2 and Akt to Promote Recovery from Motor Dysfunction and Muscle Atrophy Induced by Sciatic Nerve Injury" @default.
- W2911740147 doi "https://doi.org/10.20944/preprints201901.0250.v1" @default.
- W2911740147 hasPublicationYear "2019" @default.
- W2911740147 type Work @default.
- W2911740147 sameAs 2911740147 @default.
- W2911740147 citedByCount "1" @default.
- W2911740147 countsByYear W29117401472019 @default.
- W2911740147 crossrefType "posted-content" @default.
- W2911740147 hasAuthorship W2911740147A5004738239 @default.
- W2911740147 hasAuthorship W2911740147A5006663167 @default.
- W2911740147 hasAuthorship W2911740147A5009633710 @default.
- W2911740147 hasAuthorship W2911740147A5016137949 @default.
- W2911740147 hasAuthorship W2911740147A5028583663 @default.
- W2911740147 hasAuthorship W2911740147A5033366805 @default.
- W2911740147 hasAuthorship W2911740147A5051583053 @default.
- W2911740147 hasAuthorship W2911740147A5055764710 @default.
- W2911740147 hasAuthorship W2911740147A5058452964 @default.
- W2911740147 hasBestOaLocation W29117401471 @default.
- W2911740147 hasConcept C104317684 @default.
- W2911740147 hasConcept C11960822 @default.
- W2911740147 hasConcept C126322002 @default.
- W2911740147 hasConcept C127561419 @default.
- W2911740147 hasConcept C134018914 @default.
- W2911740147 hasConcept C16993767 @default.
- W2911740147 hasConcept C185592680 @default.
- W2911740147 hasConcept C2775991916 @default.
- W2911740147 hasConcept C2776263037 @default.
- W2911740147 hasConcept C2776588550 @default.
- W2911740147 hasConcept C2779837120 @default.
- W2911740147 hasConcept C2781149210 @default.
- W2911740147 hasConcept C2781172350 @default.
- W2911740147 hasConcept C42219234 @default.
- W2911740147 hasConcept C55493867 @default.
- W2911740147 hasConcept C71924100 @default.
- W2911740147 hasConcept C75217442 @default.
- W2911740147 hasConcept C90149880 @default.
- W2911740147 hasConcept C94412978 @default.
- W2911740147 hasConceptScore W2911740147C104317684 @default.
- W2911740147 hasConceptScore W2911740147C11960822 @default.
- W2911740147 hasConceptScore W2911740147C126322002 @default.
- W2911740147 hasConceptScore W2911740147C127561419 @default.
- W2911740147 hasConceptScore W2911740147C134018914 @default.
- W2911740147 hasConceptScore W2911740147C16993767 @default.
- W2911740147 hasConceptScore W2911740147C185592680 @default.
- W2911740147 hasConceptScore W2911740147C2775991916 @default.
- W2911740147 hasConceptScore W2911740147C2776263037 @default.
- W2911740147 hasConceptScore W2911740147C2776588550 @default.
- W2911740147 hasConceptScore W2911740147C2779837120 @default.
- W2911740147 hasConceptScore W2911740147C2781149210 @default.
- W2911740147 hasConceptScore W2911740147C2781172350 @default.
- W2911740147 hasConceptScore W2911740147C42219234 @default.
- W2911740147 hasConceptScore W2911740147C55493867 @default.
- W2911740147 hasConceptScore W2911740147C71924100 @default.
- W2911740147 hasConceptScore W2911740147C75217442 @default.
- W2911740147 hasConceptScore W2911740147C90149880 @default.
- W2911740147 hasConceptScore W2911740147C94412978 @default.
- W2911740147 hasLocation W29117401471 @default.
- W2911740147 hasOpenAccess W2911740147 @default.
- W2911740147 hasPrimaryLocation W29117401471 @default.
- W2911740147 hasRelatedWork W1991835308 @default.
- W2911740147 hasRelatedWork W2055946353 @default.
- W2911740147 hasRelatedWork W2515610596 @default.
- W2911740147 hasRelatedWork W2519997410 @default.
- W2911740147 hasRelatedWork W2895007807 @default.
- W2911740147 hasRelatedWork W2911740147 @default.
- W2911740147 hasRelatedWork W2944056965 @default.
- W2911740147 hasRelatedWork W3022613391 @default.
- W2911740147 hasRelatedWork W4225894859 @default.
- W2911740147 hasRelatedWork W4284958961 @default.
- W2911740147 isParatext "false" @default.
- W2911740147 isRetracted "false" @default.
- W2911740147 magId "2911740147" @default.
- W2911740147 workType "article" @default.