Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911741036> ?p ?o ?g. }
- W2911741036 abstract "Cancer progression involves complex signals within the tumor microenvironment that orchestrate proliferation and invasive processes. The mechanical properties of the extracellular matrix (ECM) within this microenvironment has been demonstrated to influence growth and the migratory phenotype that precedes invasion. Here we present the integration of a label-free quantitative phase imaging technique, spatial light interference microscopy (SLIM)-with protein-conjugated hydrogel substrates-to explore how the stiffness of the ECM influences melanoma cells of varying metastatic potential. Melanoma cells of high metastatic potential demonstrate increased growth and velocity characteristics relative to cells of low metastatic potential. Cell velocity in the highly metastatic population shows a relative insensitivity to matrix stiffness suggesting adoption of migratory routines that are independent of mechanics to facilitate invasion. The use of SLIM and engineered substrates provides a new approach to characterize the invasive properties of live cells as a function of microenvironment parameters. This work provides fundamental insight into the relationship between growth, migration and metastatic potential, and provides a new tool for profiling cancer cells for clinical grading and development of patient-specific therapeutic regimens." @default.
- W2911741036 created "2019-02-21" @default.
- W2911741036 creator A5050044819 @default.
- W2911741036 creator A5056127619 @default.
- W2911741036 creator A5071440595 @default.
- W2911741036 creator A5090797299 @default.
- W2911741036 date "2019-01-22" @default.
- W2911741036 modified "2023-10-17" @default.
- W2911741036 title "Quantitative phase imaging reveals matrix stiffness-dependent growth and migration of cancer cells" @default.
- W2911741036 cites W1587510658 @default.
- W2911741036 cites W1792045378 @default.
- W2911741036 cites W1890402826 @default.
- W2911741036 cites W1964596167 @default.
- W2911741036 cites W1974655589 @default.
- W2911741036 cites W1985727076 @default.
- W2911741036 cites W1989095124 @default.
- W2911741036 cites W1995698795 @default.
- W2911741036 cites W1999356404 @default.
- W2911741036 cites W2007897263 @default.
- W2911741036 cites W2021510179 @default.
- W2911741036 cites W2021597202 @default.
- W2911741036 cites W2024315189 @default.
- W2911741036 cites W2033275247 @default.
- W2911741036 cites W2033998652 @default.
- W2911741036 cites W2050659938 @default.
- W2911741036 cites W2054635074 @default.
- W2911741036 cites W2060566320 @default.
- W2911741036 cites W2060932651 @default.
- W2911741036 cites W2062809449 @default.
- W2911741036 cites W2064297038 @default.
- W2911741036 cites W2067813258 @default.
- W2911741036 cites W2072888577 @default.
- W2911741036 cites W2083879966 @default.
- W2911741036 cites W2086244192 @default.
- W2911741036 cites W2092459115 @default.
- W2911741036 cites W2094817410 @default.
- W2911741036 cites W2098882954 @default.
- W2911741036 cites W2100303404 @default.
- W2911741036 cites W2101728107 @default.
- W2911741036 cites W2109995938 @default.
- W2911741036 cites W2110344693 @default.
- W2911741036 cites W2115124692 @default.
- W2911741036 cites W2123647329 @default.
- W2911741036 cites W2132566055 @default.
- W2911741036 cites W2133135568 @default.
- W2911741036 cites W2144023435 @default.
- W2911741036 cites W2148328620 @default.
- W2911741036 cites W2154589460 @default.
- W2911741036 cites W2164846110 @default.
- W2911741036 cites W2168939634 @default.
- W2911741036 cites W2172237567 @default.
- W2911741036 cites W2320821933 @default.
- W2911741036 cites W2476542314 @default.
- W2911741036 cites W2517760358 @default.
- W2911741036 cites W2522947286 @default.
- W2911741036 cites W2565072241 @default.
- W2911741036 cites W2573970795 @default.
- W2911741036 cites W2597286858 @default.
- W2911741036 cites W2604598204 @default.
- W2911741036 cites W2649073763 @default.
- W2911741036 cites W2734617308 @default.
- W2911741036 cites W2759276314 @default.
- W2911741036 cites W2766329194 @default.
- W2911741036 cites W4240691888 @default.
- W2911741036 cites W4249023884 @default.
- W2911741036 doi "https://doi.org/10.1038/s41598-018-36551-5" @default.
- W2911741036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343033" @default.
- W2911741036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30670739" @default.
- W2911741036 hasPublicationYear "2019" @default.
- W2911741036 type Work @default.
- W2911741036 sameAs 2911741036 @default.
- W2911741036 citedByCount "40" @default.
- W2911741036 countsByYear W29117410362019 @default.
- W2911741036 countsByYear W29117410362020 @default.
- W2911741036 countsByYear W29117410362021 @default.
- W2911741036 countsByYear W29117410362022 @default.
- W2911741036 countsByYear W29117410362023 @default.
- W2911741036 crossrefType "journal-article" @default.
- W2911741036 hasAuthorship W2911741036A5050044819 @default.
- W2911741036 hasAuthorship W2911741036A5056127619 @default.
- W2911741036 hasAuthorship W2911741036A5071440595 @default.
- W2911741036 hasAuthorship W2911741036A5090797299 @default.
- W2911741036 hasBestOaLocation W29117410361 @default.
- W2911741036 hasConcept C121608353 @default.
- W2911741036 hasConcept C137738243 @default.
- W2911741036 hasConcept C1491633281 @default.
- W2911741036 hasConcept C185592680 @default.
- W2911741036 hasConcept C189165786 @default.
- W2911741036 hasConcept C2776107976 @default.
- W2911741036 hasConcept C2777658100 @default.
- W2911741036 hasConcept C2779013556 @default.
- W2911741036 hasConcept C3020616263 @default.
- W2911741036 hasConcept C502942594 @default.
- W2911741036 hasConcept C54355233 @default.
- W2911741036 hasConcept C86803240 @default.
- W2911741036 hasConcept C95444343 @default.
- W2911741036 hasConcept C96232424 @default.
- W2911741036 hasConceptScore W2911741036C121608353 @default.
- W2911741036 hasConceptScore W2911741036C137738243 @default.
- W2911741036 hasConceptScore W2911741036C1491633281 @default.