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- W2911781180 abstract "Despite the significantly increased risk of invasive pneumococcal disease among patients with asthma, the association of socio-economic status (SES) with antibody titers is not known. We conducted a prospective study to assess the association of pneumococcal titers and immune response to PPSV23 to SES. We prospectively enrolled 50 asthmatics between 19-21 years old that did not have a history of PPSV23 from Mayo Clinic primary care practice. One person in 50 had PCV-7 while none had PCV-13 immunization in childhood. Pneumococcal titers for 23 serotypes were measured at baseline and 6 weeks post vaccination. SES was measured by HOUSES, a validated individual-level housing-based SES index (the higher HOUSES, the greater SES). The study approval and oversight was by the Mayo Clinic IRB. Asthma control test (ACT) scores at baseline did not differ by SES measured by HOUSES among subjects. A majority of baseline titers of PPSV23 showed positive association with HOUSES (P<0.05 for 7 titers: 1, 10A, 12F, 15B, 18C, 19F, 22F, 5, 7F, 8 and p: 0.05-0.1 for 4 titers: 23F, 3, 9N and 9V). Fold change of 20 out of 23 titers showed no association with HOUSES. Lower SES is associated with lower baseline PPSV23 titers and SES may be an unrecognized determinant of vaccine responses. PPSV23 vaccination may reduce health disparities by SES in risk of pneumococcal pneumonia in asthmatics. While the mechanisms underlying this observation are studied, whether this observation is true for other vaccine titers need to be elucidated." @default.
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- W2911781180 date "2019-02-01" @default.
- W2911781180 modified "2023-09-23" @default.
- W2911781180 title "Lower socioeconomic status predicts lower pneumococcal antibody titers among young adults with asthma" @default.
- W2911781180 doi "https://doi.org/10.1016/j.jaci.2018.12.689" @default.
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