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- W2911790418 abstract "Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high mortality rates and survivors of aSAH often experience persistent deficits across multiple domains, including language, memory, perception and frontal lobe executive function. At present, little is known about the alterations in brain structure and function associated with aSAH, and specific brain biomarkers of post-stroke impairment. In this study, N=28 individuals were scanned using a comprehensive multi-modal neuroimaging battery, including 14 with chronic aSAH and 14 matched controls. Using a 3T Magnetic Resonance Imaging (MRI) scanner, we acquired resting state functional MRI (rs-fMRI), diffusion tensor imaging (DTI) and T1-weighted voxel-based morphometry (VBM). Comparing aSAH patients to controls, we observed elevated rs-fMRI measures of global connectivity and decreased VBM measures of grey matter, primarily within the midcingulate cortex, but no consistent alterations were seen in DTI measures of white matter. Within-group analysis of aSAH patients subsequently showed that greater impairments in executive function were associated with altered DTI measures, including elevated diffusivity and reduced fractional anisotropy, mainly within posterior corona radiata. These findings indicate that brain function and cortical volume are reliably altered post-stroke, whereas the effects on white matter microstructure depend on the severity of post-stroke impairment. These results provide novel information about potential neuroimaging biomarkers of recovery following aSAH." @default.
- W2911790418 created "2019-02-21" @default.
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- W2911790418 date "2019-02-01" @default.
- W2911790418 modified "2023-09-26" @default.
- W2911790418 title "Abstract WP454: Multi-modal Neuroimaging Biomarkers of Aneurysmal Subarachnoid Hemorrhage" @default.
- W2911790418 doi "https://doi.org/10.1161/str.50.suppl_1.wp454" @default.
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