Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911809954> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2911809954 abstract "OBJECTIVES: 1. To measure serum granulysin levels and study its relationship with disease severity in patients with drug induced exanthems and severe cutaneous adverse reactions. 2. To study the clinical and cutaneous profile of patients with drug induced exanthems and severe cutaneous adverse reactions. METHODS: A prospective case-control study was conducted for a period of 19 months. Twenty two cases of maculopapular exanthema and twenty one cases of severe cutaneous adverse reactions were recruited. Twenty age-matched healthy volunteers were also enrolled as controls. Naranjo adverse drug reaction probability scale was used to determine causality. A detailed history was taken and examination was conducted. The serum granulsyin was measured with Biovendor RD191327200R Human Granulysin ELISA, a sandwich-enzyme linked immunosorbent assay. The data entry was performed using Epidata software and analysis by using SPSS software. The independent sample t test was used for the comparison of normally distributed variables. RESULTS:The mean age of the patients was 44.4 ± 14.6 years. There was a female preponderance with M : F 0.41:1. Aromatic anticonvulsants were the most commonly implicated drug group (35.4%). Facial oedema and peripheral eosinophilia among patients with MPE and SCARs were comparable (p – 0.929, >0.99 respectively). Transaminitis was significantly more common in SCARs than MPE (p value 0.021). Dermal eosinophilia was the most common histopathological feature in CADRs (83.3%). Necrotic keratinocytes and lymphocytic exocytosis were significantly more common in SCARs than MPE (p – 0.01, 0.045 respectively). There was no significant difference in serum granulysin between patients with MPE, SCARs and healthy controls. Granulysin titer was significantly higher in patients with SJS/TEN than in patients with erythema multiforme major (0.275 ng/ml vs 0.125 ng/ml, p value – 0.042)." @default.
- W2911809954 created "2019-02-21" @default.
- W2911809954 creator A5075060148 @default.
- W2911809954 date "2018-05-01" @default.
- W2911809954 modified "2023-09-27" @default.
- W2911809954 title "A pilot study of serum granulysin in drug induced exanthems and severe cutaneous adverse reactions (SCARs)" @default.
- W2911809954 hasPublicationYear "2018" @default.
- W2911809954 type Work @default.
- W2911809954 sameAs 2911809954 @default.
- W2911809954 citedByCount "0" @default.
- W2911809954 crossrefType "dissertation" @default.
- W2911809954 hasAuthorship W2911809954A5075060148 @default.
- W2911809954 hasConcept C126322002 @default.
- W2911809954 hasConcept C141071460 @default.
- W2911809954 hasConcept C16005928 @default.
- W2911809954 hasConcept C167672396 @default.
- W2911809954 hasConcept C197934379 @default.
- W2911809954 hasConcept C203014093 @default.
- W2911809954 hasConcept C2776062744 @default.
- W2911809954 hasConcept C2777129736 @default.
- W2911809954 hasConcept C2777642821 @default.
- W2911809954 hasConcept C2777966294 @default.
- W2911809954 hasConcept C2779515644 @default.
- W2911809954 hasConcept C2780035454 @default.
- W2911809954 hasConcept C2780542314 @default.
- W2911809954 hasConcept C71924100 @default.
- W2911809954 hasConcept C8891405 @default.
- W2911809954 hasConcept C90924648 @default.
- W2911809954 hasConcept C98274493 @default.
- W2911809954 hasConceptScore W2911809954C126322002 @default.
- W2911809954 hasConceptScore W2911809954C141071460 @default.
- W2911809954 hasConceptScore W2911809954C16005928 @default.
- W2911809954 hasConceptScore W2911809954C167672396 @default.
- W2911809954 hasConceptScore W2911809954C197934379 @default.
- W2911809954 hasConceptScore W2911809954C203014093 @default.
- W2911809954 hasConceptScore W2911809954C2776062744 @default.
- W2911809954 hasConceptScore W2911809954C2777129736 @default.
- W2911809954 hasConceptScore W2911809954C2777642821 @default.
- W2911809954 hasConceptScore W2911809954C2777966294 @default.
- W2911809954 hasConceptScore W2911809954C2779515644 @default.
- W2911809954 hasConceptScore W2911809954C2780035454 @default.
- W2911809954 hasConceptScore W2911809954C2780542314 @default.
- W2911809954 hasConceptScore W2911809954C71924100 @default.
- W2911809954 hasConceptScore W2911809954C8891405 @default.
- W2911809954 hasConceptScore W2911809954C90924648 @default.
- W2911809954 hasConceptScore W2911809954C98274493 @default.
- W2911809954 hasLocation W29118099541 @default.
- W2911809954 hasOpenAccess W2911809954 @default.
- W2911809954 hasPrimaryLocation W29118099541 @default.
- W2911809954 hasRelatedWork W1886304235 @default.
- W2911809954 hasRelatedWork W1901880560 @default.
- W2911809954 hasRelatedWork W2109712384 @default.
- W2911809954 hasRelatedWork W2146442018 @default.
- W2911809954 hasRelatedWork W2397713627 @default.
- W2911809954 hasRelatedWork W2397835199 @default.
- W2911809954 hasRelatedWork W2401363006 @default.
- W2911809954 hasRelatedWork W2416503646 @default.
- W2911809954 hasRelatedWork W2418843901 @default.
- W2911809954 hasRelatedWork W2555634675 @default.
- W2911809954 hasRelatedWork W2620055410 @default.
- W2911809954 hasRelatedWork W2922253552 @default.
- W2911809954 hasRelatedWork W2924335334 @default.
- W2911809954 hasRelatedWork W2949813800 @default.
- W2911809954 hasRelatedWork W2998675207 @default.
- W2911809954 hasRelatedWork W3021507985 @default.
- W2911809954 hasRelatedWork W3031138664 @default.
- W2911809954 hasRelatedWork W3031690937 @default.
- W2911809954 hasRelatedWork W3112873801 @default.
- W2911809954 hasRelatedWork W3162587419 @default.
- W2911809954 isParatext "false" @default.
- W2911809954 isRetracted "false" @default.
- W2911809954 magId "2911809954" @default.
- W2911809954 workType "dissertation" @default.