FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911811702> ?p ?o ?g. }

• W2911811702 endingPage "101117" @default.
• W2911811702 startingPage "101117" @default.
• W2911811702 abstract "Hepatic sinusoidal obstruction syndrome (HSOS) is a rare liver disease with considerable morbidity and mortality. (-)-Epicatechin (EPI) is a natural flavonol. This study aims to investigate the protection of EPI against monocrotaline (MCT)-induced HSOS and its engaged mechanism. Results of serum alanine/aspartate aminotransferases (ALT/AST) activities, total bilirubin (TBil) and bile acids (TBA) amounts, liver histological evaluation, scanning electron microscope observation and hepatic metalloproteinase-9 (MMP-9) expression all demonstrated the protection by EPI against MCT-induced HSOS in rats. EPI attenuated liver oxidative injury induced by MCT. EPI enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increased the expression of its downstream antioxidant genes in rats. Molecular docking results implied the potential interaction of EPI with the Nrf2 binding site in kelch-like ECH-associated protein-1 (Keap1). The EPI-provided protection against MCT-induced HSOS was diminished in Nrf2 knock-out mice when mice were treated with MCT for 24 h but not for 48 h. However, EPI reduced the increased liver myeloperoxidase (MPO) activity, hepatic infiltration of immune cells, pro-inflammatory cytokines expression and nuclear factor κB (NFκB) activation in both wild-type and Nrf2 knock-out mice when mice were treated with MCT for 48 h. EPI reduced the elevated serum heat shock protein 60 (HSP60) content, and reversed the decreased mitochondria expression of HSP60 and Lon in livers from MCT-treated rats. Furthermore, the MCT-induced HSOS was markedly alleviated in mice treated with anti-HSP60 antibody. Taken together, this study demonstrates that EPI attenuates MCT-induced HSOS by reducing liver oxidative injury via activating Nrf2 antioxidant pathway and inhibiting liver inflammatory injury through abrogating NFκB signaling pathway initiated by HSP60." @default.
• W2911811702 created "2019-02-21" @default.
• W2911811702 creator A5000891681 @default.
• W2911811702 creator A5011479283 @default.
• W2911811702 creator A5020285133 @default.
• W2911811702 creator A5027145131 @default.
• W2911811702 creator A5063990340 @default.
• W2911811702 creator A5070862912 @default.
• W2911811702 creator A5082785930 @default.
• W2911811702 date "2019-04-01" @default.
• W2911811702 modified "2023-10-17" @default.
• W2911811702 title "(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury" @default.
• W2911811702 cites W1192899902 @default.
• W2911811702 cites W1523966692 @default.
• W2911811702 cites W1587522694 @default.
• W2911811702 cites W1968157613 @default.
• W2911811702 cites W1984363621 @default.
• W2911811702 cites W1993783426 @default.
• W2911811702 cites W1996485480 @default.
• W2911811702 cites W1996780964 @default.
• W2911811702 cites W2005419063 @default.
• W2911811702 cites W2006201383 @default.
• W2911811702 cites W2010472426 @default.
• W2911811702 cites W2033552465 @default.
• W2911811702 cites W2037010003 @default.
• W2911811702 cites W2045176214 @default.
• W2911811702 cites W2046266642 @default.
• W2911811702 cites W2051636114 @default.
• W2911811702 cites W2053623949 @default.
• W2911811702 cites W2053724955 @default.
• W2911811702 cites W2057761159 @default.
• W2911811702 cites W2064476346 @default.
• W2911811702 cites W2065202905 @default.
• W2911811702 cites W2082441871 @default.
• W2911811702 cites W2086607120 @default.
• W2911811702 cites W2090485914 @default.
• W2911811702 cites W2142670793 @default.
• W2911811702 cites W2144917307 @default.
• W2911811702 cites W2151892297 @default.
• W2911811702 cites W2161220011 @default.
• W2911811702 cites W2221338781 @default.
• W2911811702 cites W2316688214 @default.
• W2911811702 cites W2465553039 @default.
• W2911811702 cites W2528154004 @default.
• W2911811702 cites W2562372724 @default.
• W2911811702 cites W2585269261 @default.
• W2911811702 cites W2767526444 @default.
• W2911811702 cites W2792190175 @default.
• W2911811702 cites W83454063 @default.
• W2911811702 cites W91412458 @default.
• W2911811702 doi "https://doi.org/10.1016/j.redox.2019.101117" @default.
• W2911811702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6395886" @default.
• W2911811702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30822691" @default.
• W2911811702 hasPublicationYear "2019" @default.
• W2911811702 type Work @default.
• W2911811702 sameAs 2911811702 @default.
• W2911811702 citedByCount "34" @default.
• W2911811702 countsByYear W29118117022019 @default.
• W2911811702 countsByYear W29118117022020 @default.
• W2911811702 countsByYear W29118117022021 @default.
• W2911811702 countsByYear W29118117022022 @default.
• W2911811702 countsByYear W29118117022023 @default.
• W2911811702 crossrefType "journal-article" @default.
• W2911811702 hasAuthorship W2911811702A5000891681 @default.
• W2911811702 hasAuthorship W2911811702A5011479283 @default.
• W2911811702 hasAuthorship W2911811702A5020285133 @default.
• W2911811702 hasAuthorship W2911811702A5027145131 @default.
• W2911811702 hasAuthorship W2911811702A5063990340 @default.
• W2911811702 hasAuthorship W2911811702A5070862912 @default.
• W2911811702 hasAuthorship W2911811702A5082785930 @default.
• W2911811702 hasBestOaLocation W29118117021 @default.
• W2911811702 hasConcept C104317684 @default.
• W2911811702 hasConcept C126322002 @default.
• W2911811702 hasConcept C134018914 @default.
• W2911811702 hasConcept C164027704 @default.
• W2911811702 hasConcept C185592680 @default.
• W2911811702 hasConcept C203565725 @default.
• W2911811702 hasConcept C2776151105 @default.
• W2911811702 hasConcept C2776529522 @default.
• W2911811702 hasConcept C2776637226 @default.
• W2911811702 hasConcept C2776914184 @default.
• W2911811702 hasConcept C55493867 @default.
• W2911811702 hasConcept C71924100 @default.
• W2911811702 hasConcept C86339819 @default.
• W2911811702 hasConcept C86803240 @default.
• W2911811702 hasConcept C98274493 @default.
• W2911811702 hasConceptScore W2911811702C104317684 @default.
• W2911811702 hasConceptScore W2911811702C126322002 @default.
• W2911811702 hasConceptScore W2911811702C134018914 @default.
• W2911811702 hasConceptScore W2911811702C164027704 @default.
• W2911811702 hasConceptScore W2911811702C185592680 @default.
• W2911811702 hasConceptScore W2911811702C203565725 @default.
• W2911811702 hasConceptScore W2911811702C2776151105 @default.
• W2911811702 hasConceptScore W2911811702C2776529522 @default.
• W2911811702 hasConceptScore W2911811702C2776637226 @default.
• W2911811702 hasConceptScore W2911811702C2776914184 @default.
• W2911811702 hasConceptScore W2911811702C55493867 @default.
• W2911811702 hasConceptScore W2911811702C71924100 @default.

• next