FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911814706> ?p ?o ?g. }

• W2911814706 abstract "The aim of the present study was to identify the differentially expressed genes (DEGs) between primary tumor tissue and adjacent non‑tumor tissue of hepatocellular carcinoma (HCC) samples in order to investigate the mechanisms of HCC. The microarray data of the datasets GSE76427, GSE84005 and GSE57957 were downloaded from the Gene Expression Omnibus database. DEGs were identified using the limma package in the R programming language. Following the intersection of the DEGs screened from the three datasets, 218 genes were selected for further study. A protein‑protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes database. The construction and analysis of modules were performed using Cytoscape and the module with the highest score was selected for further analysis. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were conducted for genes involved in the PPI network and the selected subnetwork. The network of the enriched pathways and their associated genes was constructed using Cytoscape. For the genes in the global PPI network, metabolism‑associated pathways were significantly enriched; whereas, for the genes in the subnetwork, 'cell cycle', 'oocyte meiosis' and 'DNA replication' pathways were significantly enriched. To demonstrate the portability and repeatability of the prognostic value of the weighted genes, a validation cohort was obtained from datasets of The Cancer Genome Atlas and Kaplan‑Meier survival analysis was conducted. Evidence is presented that the expression levels of aldehyde dehydrogenase 2 family member, cytochrome P450 family 2 subfamily C member 8, alcohol dehydrogenase 4 (class II), pi polypeptide, alcohol dehydrogenase 1B (class I), β polypeptide and cytochrome P450 family 2 subfamily C member 9 were associated with the overall survival of patients with HCC and that the expression levels of pituitary tumor‑transforming 1, cell division cycle 20, DNA topoisomerase II α and cyclin B2 were negatively associated with the overall survival of patients with HCC. In conclusion, 9 weighted genes, involved in the development and progression of HCC, were identified using bioinformatics and survival analyses." @default.
• W2911814706 created "2019-02-21" @default.
• W2911814706 creator A5007898420 @default.
• W2911814706 creator A5018691033 @default.
• W2911814706 creator A5031734733 @default.
• W2911814706 creator A5034311245 @default.
• W2911814706 creator A5048499347 @default.
• W2911814706 creator A5053318778 @default.
• W2911814706 creator A5054453464 @default.
• W2911814706 creator A5091144044 @default.
• W2911814706 date "2019-02-04" @default.
• W2911814706 modified "2023-09-29" @default.
• W2911814706 title "Prediction and analysis of weighted genes in hepatocellular carcinoma using bioinformatics analysis" @default.
• W2911814706 cites W1578421007 @default.
• W2911814706 cites W1863264787 @default.
• W2911814706 cites W1895889333 @default.
• W2911814706 cites W1972418337 @default.
• W2911814706 cites W1983218872 @default.
• W2911814706 cites W2003526937 @default.
• W2911814706 cites W2006881406 @default.
• W2911814706 cites W2032352097 @default.
• W2911814706 cites W2043006462 @default.
• W2911814706 cites W2048235666 @default.
• W2911814706 cites W2048793404 @default.
• W2911814706 cites W2061743943 @default.
• W2911814706 cites W2072554662 @default.
• W2911814706 cites W2075005938 @default.
• W2911814706 cites W2075959498 @default.
• W2911814706 cites W2087810003 @default.
• W2911814706 cites W2106235111 @default.
• W2911814706 cites W2109972881 @default.
• W2911814706 cites W2112513984 @default.
• W2911814706 cites W2132927623 @default.
• W2911814706 cites W2136850043 @default.
• W2911814706 cites W2146512944 @default.
• W2911814706 cites W2152026276 @default.
• W2911814706 cites W2159675211 @default.
• W2911814706 cites W2169589032 @default.
• W2911814706 cites W2275678839 @default.
• W2911814706 cites W2314818532 @default.
• W2911814706 cites W2461132387 @default.
• W2911814706 cites W2561726822 @default.
• W2911814706 cites W2767965002 @default.
• W2911814706 cites W2781525129 @default.
• W2911814706 doi "https://doi.org/10.3892/mmr.2019.9929" @default.
• W2911814706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6423588" @default.
• W2911814706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720105" @default.
• W2911814706 hasPublicationYear "2019" @default.
• W2911814706 type Work @default.
• W2911814706 sameAs 2911814706 @default.
• W2911814706 citedByCount "7" @default.
• W2911814706 countsByYear W29118147062019 @default.
• W2911814706 countsByYear W29118147062020 @default.
• W2911814706 countsByYear W29118147062021 @default.
• W2911814706 countsByYear W29118147062023 @default.
• W2911814706 crossrefType "journal-article" @default.
• W2911814706 hasAuthorship W2911814706A5007898420 @default.
• W2911814706 hasAuthorship W2911814706A5018691033 @default.
• W2911814706 hasAuthorship W2911814706A5031734733 @default.
• W2911814706 hasAuthorship W2911814706A5034311245 @default.
• W2911814706 hasAuthorship W2911814706A5048499347 @default.
• W2911814706 hasAuthorship W2911814706A5053318778 @default.
• W2911814706 hasAuthorship W2911814706A5054453464 @default.
• W2911814706 hasAuthorship W2911814706A5091144044 @default.
• W2911814706 hasBestOaLocation W29118147061 @default.
• W2911814706 hasConcept C104317684 @default.
• W2911814706 hasConcept C150194340 @default.
• W2911814706 hasConcept C152724338 @default.
• W2911814706 hasConcept C162317418 @default.
• W2911814706 hasConcept C29537977 @default.
• W2911814706 hasConcept C54355233 @default.
• W2911814706 hasConcept C60644358 @default.
• W2911814706 hasConcept C70721500 @default.
• W2911814706 hasConcept C8415881 @default.
• W2911814706 hasConcept C86803240 @default.
• W2911814706 hasConceptScore W2911814706C104317684 @default.
• W2911814706 hasConceptScore W2911814706C150194340 @default.
• W2911814706 hasConceptScore W2911814706C152724338 @default.
• W2911814706 hasConceptScore W2911814706C162317418 @default.
• W2911814706 hasConceptScore W2911814706C29537977 @default.
• W2911814706 hasConceptScore W2911814706C54355233 @default.
• W2911814706 hasConceptScore W2911814706C60644358 @default.
• W2911814706 hasConceptScore W2911814706C70721500 @default.
• W2911814706 hasConceptScore W2911814706C8415881 @default.
• W2911814706 hasConceptScore W2911814706C86803240 @default.
• W2911814706 hasLocation W29118147061 @default.
• W2911814706 hasLocation W29118147062 @default.
• W2911814706 hasLocation W29118147063 @default.
• W2911814706 hasLocation W29118147064 @default.
• W2911814706 hasOpenAccess W2911814706 @default.
• W2911814706 hasPrimaryLocation W29118147061 @default.
• W2911814706 hasRelatedWork W1556453709 @default.
• W2911814706 hasRelatedWork W2509567726 @default.
• W2911814706 hasRelatedWork W2888934526 @default.
• W2911814706 hasRelatedWork W2897350575 @default.
• W2911814706 hasRelatedWork W2967392659 @default.
• W2911814706 hasRelatedWork W3025961873 @default.
• W2911814706 hasRelatedWork W3095610875 @default.
• W2911814706 hasRelatedWork W3153252782 @default.
• W2911814706 hasRelatedWork W4224439911 @default.

• next