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- W2911820420 abstract "Significance Posttranscriptional RNA interference-mediated antiviral defense is well conserved, in which the key players, Dicer and Argonaute, act to digest viral RNAs. Utilizing a filamentous fungus model, we have previously shown the Spt–Ada–Gcn5 acetyltransferase (SAGA) transcriptional activator to regulate the upregulation of the two main antiviral RNA-silencing components, dicer-like 2 ( dcl2 ) and argonaute-like 2 ( agl2 ). Here, we show an additional distinct functional role for DCL2 in the virus-responsive, SAGA-mediated transcriptional upregulation of a subset of host genes. Strikingly, certain upregulated genes contribute to mitigate viral symptom induction. No involvement of Argonaute in this Dicer function is suggested by the agl2 disruption assay. Therefore, DCL2 is bifunctional in dual-layer antiviral defense to inhibit viral replication and alleviate symptom expression." @default.
- W2911820420 created "2019-02-21" @default.
- W2911820420 creator A5051365229 @default.
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- W2911820420 date "2019-01-23" @default.
- W2911820420 modified "2023-10-16" @default.
- W2911820420 title "Dicer functions transcriptionally and posttranscriptionally in a multilayer antiviral defense" @default.
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- W2911820420 doi "https://doi.org/10.1073/pnas.1812407116" @default.
- W2911820420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369764" @default.
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