Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911822095> ?p ?o ?g. }
- W2911822095 endingPage "65" @default.
- W2911822095 startingPage "56" @default.
- W2911822095 abstract "Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell migration and invasion assays, immunoblotting and immunostaining. EphB4 was expressed in glioma cell lines and stem-like cell lines. The stimulation of glioma cells with ephrin-B2, the sole ligand of EphB4, conducted EphB4 phosphorylation and suppressed migration and invasion that downregulation of EphB4 using small interfering RNA abrogated. The stimulation also suppressed the phosphorylation of Akt. We confirmed by immunostaining that EphB4-positive cells existing only in the tumor core, whereas ephrin-B2-positive cells widespread in both the tumor core and the invasive area signifying that EphB4-ephrin-B2 reaction occurred only at the tumor core. Taken together, our data suggest that ephrin-B2-dependent EphB4 phosphorylation acts as an anchoring signal to reduce the malignancy by inhibiting Akt phosphorylation in the glioma core, whereas the scarcity of signaling in the tumor periphery promotes invasion into the surrounding brain." @default.
- W2911822095 created "2019-02-21" @default.
- W2911822095 creator A5001388179 @default.
- W2911822095 creator A5008290857 @default.
- W2911822095 creator A5022608763 @default.
- W2911822095 creator A5027286765 @default.
- W2911822095 creator A5028333319 @default.
- W2911822095 creator A5033779135 @default.
- W2911822095 creator A5034771136 @default.
- W2911822095 creator A5037052532 @default.
- W2911822095 creator A5041366103 @default.
- W2911822095 creator A5054791434 @default.
- W2911822095 creator A5057493826 @default.
- W2911822095 creator A5060081405 @default.
- W2911822095 date "2019-05-01" @default.
- W2911822095 modified "2023-09-23" @default.
- W2911822095 title "Ligand-dependent EphB4 activation serves as an anchoring signal in glioma cells" @default.
- W2911822095 cites W1584018958 @default.
- W2911822095 cites W1972028817 @default.
- W2911822095 cites W1972486937 @default.
- W2911822095 cites W1973648086 @default.
- W2911822095 cites W1982550220 @default.
- W2911822095 cites W1986138661 @default.
- W2911822095 cites W1987263161 @default.
- W2911822095 cites W1999778470 @default.
- W2911822095 cites W2001954506 @default.
- W2911822095 cites W2027098220 @default.
- W2911822095 cites W2034064964 @default.
- W2911822095 cites W2039233803 @default.
- W2911822095 cites W2056879227 @default.
- W2911822095 cites W2062258104 @default.
- W2911822095 cites W2070857068 @default.
- W2911822095 cites W2073522864 @default.
- W2911822095 cites W2077659995 @default.
- W2911822095 cites W2080898465 @default.
- W2911822095 cites W2085397699 @default.
- W2911822095 cites W2090325463 @default.
- W2911822095 cites W2097029869 @default.
- W2911822095 cites W2098798730 @default.
- W2911822095 cites W2102509984 @default.
- W2911822095 cites W2113163631 @default.
- W2911822095 cites W2135456387 @default.
- W2911822095 cites W2136266904 @default.
- W2911822095 cites W2137525036 @default.
- W2911822095 cites W2139726179 @default.
- W2911822095 cites W2142900503 @default.
- W2911822095 cites W2144205331 @default.
- W2911822095 cites W2146363635 @default.
- W2911822095 cites W2166780735 @default.
- W2911822095 cites W2170210185 @default.
- W2911822095 cites W2184942696 @default.
- W2911822095 cites W2312955861 @default.
- W2911822095 cites W2328727307 @default.
- W2911822095 cites W2745796555 @default.
- W2911822095 cites W2762446768 @default.
- W2911822095 cites W2773578268 @default.
- W2911822095 cites W4229680502 @default.
- W2911822095 cites W4242403727 @default.
- W2911822095 doi "https://doi.org/10.1016/j.canlet.2019.02.021" @default.
- W2911822095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776480" @default.
- W2911822095 hasPublicationYear "2019" @default.
- W2911822095 type Work @default.
- W2911822095 sameAs 2911822095 @default.
- W2911822095 citedByCount "7" @default.
- W2911822095 countsByYear W29118220952020 @default.
- W2911822095 countsByYear W29118220952022 @default.
- W2911822095 countsByYear W29118220952023 @default.
- W2911822095 crossrefType "journal-article" @default.
- W2911822095 hasAuthorship W2911822095A5001388179 @default.
- W2911822095 hasAuthorship W2911822095A5008290857 @default.
- W2911822095 hasAuthorship W2911822095A5022608763 @default.
- W2911822095 hasAuthorship W2911822095A5027286765 @default.
- W2911822095 hasAuthorship W2911822095A5028333319 @default.
- W2911822095 hasAuthorship W2911822095A5033779135 @default.
- W2911822095 hasAuthorship W2911822095A5034771136 @default.
- W2911822095 hasAuthorship W2911822095A5037052532 @default.
- W2911822095 hasAuthorship W2911822095A5041366103 @default.
- W2911822095 hasAuthorship W2911822095A5054791434 @default.
- W2911822095 hasAuthorship W2911822095A5057493826 @default.
- W2911822095 hasAuthorship W2911822095A5060081405 @default.
- W2911822095 hasConcept C104317684 @default.
- W2911822095 hasConcept C11960822 @default.
- W2911822095 hasConcept C127561419 @default.
- W2911822095 hasConcept C170286479 @default.
- W2911822095 hasConcept C203014093 @default.
- W2911822095 hasConcept C204232928 @default.
- W2911822095 hasConcept C2778227246 @default.
- W2911822095 hasConcept C4224716 @default.
- W2911822095 hasConcept C502942594 @default.
- W2911822095 hasConcept C55493867 @default.
- W2911822095 hasConcept C62478195 @default.
- W2911822095 hasConcept C75217442 @default.
- W2911822095 hasConcept C86803240 @default.
- W2911822095 hasConcept C95444343 @default.
- W2911822095 hasConceptScore W2911822095C104317684 @default.
- W2911822095 hasConceptScore W2911822095C11960822 @default.
- W2911822095 hasConceptScore W2911822095C127561419 @default.
- W2911822095 hasConceptScore W2911822095C170286479 @default.