FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911826084> ?p ?o ?g. }

• W2911826084 endingPage "268" @default.
• W2911826084 startingPage "260" @default.
• W2911826084 abstract "A realistic molecular description of amorphous drug-polymer-plasticizer matrices, suitable for the preparation of amorphous solid dispersions (ASDs) with the aid of fusion-based techniques, was evaluated. Specifically, the incorporation of two model drugs (i.e. ibuprofen, IBU, and carbamazepine, CBZ) having substantially different thermal properties and glass forming ability, on the molecular representation of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (SOL)/polyethylene glycol (PEG, working as a plasticizer) molecular and thermal properties were evaluated with the aid of classical molecular dynamics (MD) and docking simulations. Results showed good agreement between molecular modelling estimations and experimentally determined properties. Specifically, the computed Tg values that resulted from MD simulations for IBU-SOL/PEG and CBZ-SOL/PEG (53.8 and 54.2 °C, respectively) were in reasonable agreement with the corresponding values resulting from differential scanning calorimetry (DSC) measurements (49.8 and 50.1 °C), while both molecular modelling and experimental obtained results suggested miscibility among system components. Additionally, interactions between CBZ and SOL observed during MD simulations were verified by FTIR analysis, while MD simulations of the hydration process suggested strong molecular interactions between IBU-SOL and CBZ-SOL." @default.
• W2911826084 created "2019-02-21" @default.
• W2911826084 creator A5056170905 @default.
• W2911826084 creator A5066091655 @default.
• W2911826084 creator A5066787200 @default.
• W2911826084 creator A5069034814 @default.
• W2911826084 creator A5071584536 @default.
• W2911826084 date "2019-03-01" @default.
• W2911826084 modified "2023-09-25" @default.
• W2911826084 title "Molecular modelling and simulation of fusion-based amorphous drug dispersions in polymer/plasticizer blends" @default.
• W2911826084 cites W1505181639 @default.
• W2911826084 cites W2016461110 @default.
• W2911826084 cites W2027411654 @default.
• W2911826084 cites W2029667189 @default.
• W2911826084 cites W2032268755 @default.
• W2911826084 cites W2033884997 @default.
• W2911826084 cites W2045398797 @default.
• W2911826084 cites W2047948690 @default.
• W2911826084 cites W2049502419 @default.
• W2911826084 cites W2056601038 @default.
• W2911826084 cites W2057460770 @default.
• W2911826084 cites W2085385924 @default.
• W2911826084 cites W2086970241 @default.
• W2911826084 cites W2094966898 @default.
• W2911826084 cites W2115700022 @default.
• W2911826084 cites W2131594761 @default.
• W2911826084 cites W2150981663 @default.
• W2911826084 cites W2167642476 @default.
• W2911826084 cites W2220571906 @default.
• W2911826084 cites W2275521990 @default.
• W2911826084 cites W2318545873 @default.
• W2911826084 cites W2321603802 @default.
• W2911826084 cites W2409807219 @default.
• W2911826084 cites W2561397801 @default.
• W2911826084 cites W2570578587 @default.
• W2911826084 cites W2616272147 @default.
• W2911826084 cites W2801538540 @default.
• W2911826084 cites W2808748074 @default.
• W2911826084 cites W4236075548 @default.
• W2911826084 doi "https://doi.org/10.1016/j.ejps.2019.02.004" @default.
• W2911826084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30735824" @default.
• W2911826084 hasPublicationYear "2019" @default.
• W2911826084 type Work @default.
• W2911826084 sameAs 2911826084 @default.
• W2911826084 citedByCount "17" @default.
• W2911826084 countsByYear W29118260842019 @default.
• W2911826084 countsByYear W29118260842020 @default.
• W2911826084 countsByYear W29118260842021 @default.
• W2911826084 countsByYear W29118260842022 @default.
• W2911826084 countsByYear W29118260842023 @default.
• W2911826084 crossrefType "journal-article" @default.
• W2911826084 hasAuthorship W2911826084A5056170905 @default.
• W2911826084 hasAuthorship W2911826084A5066091655 @default.
• W2911826084 hasAuthorship W2911826084A5066787200 @default.
• W2911826084 hasAuthorship W2911826084A5069034814 @default.
• W2911826084 hasAuthorship W2911826084A5071584536 @default.
• W2911826084 hasConcept C10138342 @default.
• W2911826084 hasConcept C110884469 @default.
• W2911826084 hasConcept C121332964 @default.
• W2911826084 hasConcept C127413603 @default.
• W2911826084 hasConcept C147597530 @default.
• W2911826084 hasConcept C159985019 @default.
• W2911826084 hasConcept C162324750 @default.
• W2911826084 hasConcept C178790620 @default.
• W2911826084 hasConcept C185592680 @default.
• W2911826084 hasConcept C188027245 @default.
• W2911826084 hasConcept C192562407 @default.
• W2911826084 hasConcept C2776964284 @default.
• W2911826084 hasConcept C2778551929 @default.
• W2911826084 hasConcept C2779537395 @default.
• W2911826084 hasConcept C39519442 @default.
• W2911826084 hasConcept C42360764 @default.
• W2911826084 hasConcept C521977710 @default.
• W2911826084 hasConcept C54400483 @default.
• W2911826084 hasConcept C56052488 @default.
• W2911826084 hasConcept C58968531 @default.
• W2911826084 hasConcept C59593255 @default.
• W2911826084 hasConcept C97355855 @default.
• W2911826084 hasConceptScore W2911826084C10138342 @default.
• W2911826084 hasConceptScore W2911826084C110884469 @default.
• W2911826084 hasConceptScore W2911826084C121332964 @default.
• W2911826084 hasConceptScore W2911826084C127413603 @default.
• W2911826084 hasConceptScore W2911826084C147597530 @default.
• W2911826084 hasConceptScore W2911826084C159985019 @default.
• W2911826084 hasConceptScore W2911826084C162324750 @default.
• W2911826084 hasConceptScore W2911826084C178790620 @default.
• W2911826084 hasConceptScore W2911826084C185592680 @default.
• W2911826084 hasConceptScore W2911826084C188027245 @default.
• W2911826084 hasConceptScore W2911826084C192562407 @default.
• W2911826084 hasConceptScore W2911826084C2776964284 @default.
• W2911826084 hasConceptScore W2911826084C2778551929 @default.
• W2911826084 hasConceptScore W2911826084C2779537395 @default.
• W2911826084 hasConceptScore W2911826084C39519442 @default.
• W2911826084 hasConceptScore W2911826084C42360764 @default.
• W2911826084 hasConceptScore W2911826084C521977710 @default.
• W2911826084 hasConceptScore W2911826084C54400483 @default.
• W2911826084 hasConceptScore W2911826084C56052488 @default.
• W2911826084 hasConceptScore W2911826084C58968531 @default.

• next