FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911835605> ?p ?o ?g. }

• W2911835605 abstract "Abstract Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise. Despite more than three decades of research and clinical trials, specific diagnostic and therapeutic strategies for sepsis are still absent. The use of LFQ‐ and TMT‐based quantitative proteomics is reported here to study the plasma proteome in five mouse models of sepsis. A knowledge‐based interpretation of the data reveals a protein network with extensive connectivity through documented functional or physical interactions. The individual proteins in the network all have a documented role in sepsis and are known to be extracellular. The changes in protein abundance observed in the mouse models of sepsis have for the most part the same directionality (increased or decreased abundance) as reported in the literature for human sepsis. This network has been named the Plasma Proteome Signature of Sepsis (PPSS). The PPSS is a quantifiable molecular readout that can supplant the current symptom‐based approach used to diagnose sepsis. This type of molecular interpretation of sepsis, its progression, and its response to therapeutic intervention are an important step in advancing our understanding of sepsis, and for discovering and evaluating new therapeutic strategies." @default.
• W2911835605 created "2019-02-21" @default.
• W2911835605 creator A5015123816 @default.
• W2911835605 creator A5022635870 @default.
• W2911835605 creator A5031945526 @default.
• W2911835605 creator A5034778068 @default.
• W2911835605 creator A5039256159 @default.
• W2911835605 creator A5067026900 @default.
• W2911835605 creator A5067976238 @default.
• W2911835605 creator A5074897884 @default.
• W2911835605 date "2019-02-20" @default.
• W2911835605 modified "2023-10-16" @default.
• W2911835605 title "Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network" @default.
• W2911835605 cites W1626756748 @default.
• W2911835605 cites W1820956372 @default.
• W2911835605 cites W1878404532 @default.
• W2911835605 cites W1966597734 @default.
• W2911835605 cites W1971654402 @default.
• W2911835605 cites W1978266519 @default.
• W2911835605 cites W1979741190 @default.
• W2911835605 cites W1980123081 @default.
• W2911835605 cites W1981243375 @default.
• W2911835605 cites W1991209345 @default.
• W2911835605 cites W1994306321 @default.
• W2911835605 cites W2020379544 @default.
• W2911835605 cites W2021024902 @default.
• W2911835605 cites W2022745533 @default.
• W2911835605 cites W2028133290 @default.
• W2911835605 cites W2033591223 @default.
• W2911835605 cites W2036321220 @default.
• W2911835605 cites W2040642611 @default.
• W2911835605 cites W2059406122 @default.
• W2911835605 cites W2072232259 @default.
• W2911835605 cites W2078656440 @default.
• W2911835605 cites W2083513831 @default.
• W2911835605 cites W2097476575 @default.
• W2911835605 cites W2103715582 @default.
• W2911835605 cites W2107989776 @default.
• W2911835605 cites W2121570534 @default.
• W2911835605 cites W2128551987 @default.
• W2911835605 cites W2138956963 @default.
• W2911835605 cites W2155860474 @default.
• W2911835605 cites W2161771297 @default.
• W2911835605 cites W2164990391 @default.
• W2911835605 cites W2168613507 @default.
• W2911835605 cites W2168760666 @default.
• W2911835605 cites W2170776626 @default.
• W2911835605 cites W2191641478 @default.
• W2911835605 cites W2280404143 @default.
• W2911835605 cites W2436016506 @default.
• W2911835605 cites W2537623931 @default.
• W2911835605 cites W2608823051 @default.
• W2911835605 cites W2763715289 @default.
• W2911835605 cites W2783888699 @default.
• W2911835605 cites W2794479004 @default.
• W2911835605 cites W2895930726 @default.
• W2911835605 cites W3023757607 @default.
• W2911835605 cites W3149695318 @default.
• W2911835605 doi "https://doi.org/10.1002/pmic.201800389" @default.
• W2911835605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6447370" @default.
• W2911835605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706660" @default.
• W2911835605 hasPublicationYear "2019" @default.
• W2911835605 type Work @default.
• W2911835605 sameAs 2911835605 @default.
• W2911835605 citedByCount "12" @default.
• W2911835605 countsByYear W29118356052019 @default.
• W2911835605 countsByYear W29118356052020 @default.
• W2911835605 countsByYear W29118356052021 @default.
• W2911835605 countsByYear W29118356052022 @default.
• W2911835605 countsByYear W29118356052023 @default.
• W2911835605 crossrefType "journal-article" @default.
• W2911835605 hasAuthorship W2911835605A5015123816 @default.
• W2911835605 hasAuthorship W2911835605A5022635870 @default.
• W2911835605 hasAuthorship W2911835605A5031945526 @default.
• W2911835605 hasAuthorship W2911835605A5034778068 @default.
• W2911835605 hasAuthorship W2911835605A5039256159 @default.
• W2911835605 hasAuthorship W2911835605A5067026900 @default.
• W2911835605 hasAuthorship W2911835605A5067976238 @default.
• W2911835605 hasAuthorship W2911835605A5074897884 @default.
• W2911835605 hasBestOaLocation W29118356052 @default.
• W2911835605 hasConcept C104317684 @default.
• W2911835605 hasConcept C104397665 @default.
• W2911835605 hasConcept C203014093 @default.
• W2911835605 hasConcept C2778384902 @default.
• W2911835605 hasConcept C2994443828 @default.
• W2911835605 hasConcept C46111723 @default.
• W2911835605 hasConcept C54355233 @default.
• W2911835605 hasConcept C60644358 @default.
• W2911835605 hasConcept C70721500 @default.
• W2911835605 hasConcept C71924100 @default.
• W2911835605 hasConcept C86803240 @default.
• W2911835605 hasConcept C8891405 @default.
• W2911835605 hasConceptScore W2911835605C104317684 @default.
• W2911835605 hasConceptScore W2911835605C104397665 @default.
• W2911835605 hasConceptScore W2911835605C203014093 @default.
• W2911835605 hasConceptScore W2911835605C2778384902 @default.
• W2911835605 hasConceptScore W2911835605C2994443828 @default.
• W2911835605 hasConceptScore W2911835605C46111723 @default.
• W2911835605 hasConceptScore W2911835605C54355233 @default.
• W2911835605 hasConceptScore W2911835605C60644358 @default.

• next