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• W2911842641 abstract "Summary The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir ( LDV / SOF ) with or without ribavirin in the treatment of chronic hepatitis C ( CHC ) in patients with advanced liver disease and to analyse whether the use of LDV / SOF treatment is associated with a new occurrence of hepatocellular carcinoma ( HCC ) during and after LDV / SOF treatment. The Turkish Early Access Program provided LDV / SOF treatment to a total of 200 eligible CHC patients with advanced liver disease. The median follow‐up period was 22 months. All patients were Caucasian, 84% were infected with genotype 1b, and 24% had a liver transplantation before treatment. The sustained virological response ( SVR 12) was 86.0% with ITT analysis. SVR 12 was similar among patients with Child‐Pugh classes A, B and C disease and transplant recipients. From baseline to SVR 12, serum ALT level and MELD score were significantly improved ( P < 0.001). LDV / SOF treatment was generally well tolerated. Only one patient developed a new diagnosed HCC . Seventeen of the 35 patients, who had a history of previous HCC , developed HCC recurrence during the LDV / SOF treatment or by a median follow‐up of 6 months after treatment. HCC recurrence was less commonly observed in patients who received curative treatment for HCC compared with those patients who received noncurative treatment ( P = 0.007). In conclusion, LDV / SOF with or without ribavirin is an effective and tolerable treatment in CHC patients with advanced liver disease. Eradication is associated with improvements in liver function and a reduced risk of developing a new occurrence of HCC ." @default.
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• W2911842641 date "2019-03-08" @default.
• W2911842641 modified "2023-10-17" @default.
• W2911842641 title "Low recurrence rate of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment in a real‐world chronic hepatitis C patients cohort" @default.
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• W2911842641 doi "https://doi.org/10.1111/jvh.13075" @default.
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