Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911851282> ?p ?o ?g. }
- W2911851282 abstract "Abstract Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking at the effect of HCM mutations on the force, velocity and ATPase activity of the catalytic domain of human β-cardiac myosin have not shown clear trends leading to hypercontractility at the molecular scale. Here we present functional data showing that four separate HCM mutations located at the myosin head-tail (R249Q, H251N) and head-head (D382Y, R719W) interfaces of a folded-back sequestered state referred to as the interacting heads motif lead to a significant increase in the number of heads functionally accessible for interaction with actin. These results provide evidence that HCM mutations can modulate myosin activity by disrupting intramolecular interactions within the proposed sequestered state, thereby leading to hypercontractility at the molecular level." @default.
- W2911851282 created "2019-02-21" @default.
- W2911851282 creator A5008009431 @default.
- W2911851282 creator A5014749556 @default.
- W2911851282 creator A5030780070 @default.
- W2911851282 creator A5057606234 @default.
- W2911851282 creator A5062822629 @default.
- W2911851282 creator A5068332328 @default.
- W2911851282 creator A5078054573 @default.
- W2911851282 creator A5087168290 @default.
- W2911851282 date "2019-01-31" @default.
- W2911851282 modified "2023-09-24" @default.
- W2911851282 title "Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity" @default.
- W2911851282 cites W1827445680 @default.
- W2911851282 cites W1964517528 @default.
- W2911851282 cites W1968323807 @default.
- W2911851282 cites W1994298355 @default.
- W2911851282 cites W2008238824 @default.
- W2911851282 cites W2010124420 @default.
- W2911851282 cites W2014719041 @default.
- W2911851282 cites W2015139552 @default.
- W2911851282 cites W2037615332 @default.
- W2911851282 cites W203930211 @default.
- W2911851282 cites W2046993766 @default.
- W2911851282 cites W2049667789 @default.
- W2911851282 cites W2052869024 @default.
- W2911851282 cites W2058497997 @default.
- W2911851282 cites W2062474707 @default.
- W2911851282 cites W2068898864 @default.
- W2911851282 cites W2069543061 @default.
- W2911851282 cites W2074414105 @default.
- W2911851282 cites W2077738720 @default.
- W2911851282 cites W2082231490 @default.
- W2911851282 cites W2089369921 @default.
- W2911851282 cites W2110439703 @default.
- W2911851282 cites W2118238916 @default.
- W2911851282 cites W2121760447 @default.
- W2911851282 cites W2128739184 @default.
- W2911851282 cites W2131202031 @default.
- W2911851282 cites W2133231541 @default.
- W2911851282 cites W2133680467 @default.
- W2911851282 cites W2138515609 @default.
- W2911851282 cites W2168088273 @default.
- W2911851282 cites W2169026935 @default.
- W2911851282 cites W2170147086 @default.
- W2911851282 cites W2174308494 @default.
- W2911851282 cites W2416999276 @default.
- W2911851282 cites W2466774112 @default.
- W2911851282 cites W2517515998 @default.
- W2911851282 cites W2524819112 @default.
- W2911851282 cites W2563500873 @default.
- W2911851282 cites W2613950069 @default.
- W2911851282 cites W2624048203 @default.
- W2911851282 cites W2751119444 @default.
- W2911851282 cites W2886773254 @default.
- W2911851282 cites W2950514677 @default.
- W2911851282 cites W2951957494 @default.
- W2911851282 cites W2952474430 @default.
- W2911851282 cites W332337703 @default.
- W2911851282 doi "https://doi.org/10.1101/537159" @default.
- W2911851282 hasPublicationYear "2019" @default.
- W2911851282 type Work @default.
- W2911851282 sameAs 2911851282 @default.
- W2911851282 citedByCount "5" @default.
- W2911851282 countsByYear W29118512822019 @default.
- W2911851282 countsByYear W29118512822020 @default.
- W2911851282 countsByYear W29118512822021 @default.
- W2911851282 crossrefType "posted-content" @default.
- W2911851282 hasAuthorship W2911851282A5008009431 @default.
- W2911851282 hasAuthorship W2911851282A5014749556 @default.
- W2911851282 hasAuthorship W2911851282A5030780070 @default.
- W2911851282 hasAuthorship W2911851282A5057606234 @default.
- W2911851282 hasAuthorship W2911851282A5062822629 @default.
- W2911851282 hasAuthorship W2911851282A5068332328 @default.
- W2911851282 hasAuthorship W2911851282A5078054573 @default.
- W2911851282 hasAuthorship W2911851282A5087168290 @default.
- W2911851282 hasBestOaLocation W29118512821 @default.
- W2911851282 hasConcept C12554922 @default.
- W2911851282 hasConcept C125705527 @default.
- W2911851282 hasConcept C134018914 @default.
- W2911851282 hasConcept C15954220 @default.
- W2911851282 hasConcept C160408235 @default.
- W2911851282 hasConcept C185592680 @default.
- W2911851282 hasConcept C2780185194 @default.
- W2911851282 hasConcept C39133596 @default.
- W2911851282 hasConcept C55493867 @default.
- W2911851282 hasConcept C6997183 @default.
- W2911851282 hasConcept C74581901 @default.
- W2911851282 hasConcept C8035138 @default.
- W2911851282 hasConcept C86803240 @default.
- W2911851282 hasConcept C95444343 @default.
- W2911851282 hasConceptScore W2911851282C12554922 @default.
- W2911851282 hasConceptScore W2911851282C125705527 @default.
- W2911851282 hasConceptScore W2911851282C134018914 @default.
- W2911851282 hasConceptScore W2911851282C15954220 @default.
- W2911851282 hasConceptScore W2911851282C160408235 @default.
- W2911851282 hasConceptScore W2911851282C185592680 @default.
- W2911851282 hasConceptScore W2911851282C2780185194 @default.
- W2911851282 hasConceptScore W2911851282C39133596 @default.
- W2911851282 hasConceptScore W2911851282C55493867 @default.