FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911851957> ?p ?o ?g. }

• W2911851957 abstract "Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons, appearance of Lewy bodies and presence of neuroinflammation. No treatments currently exist to prevent PD or delay its progression, and dopaminergic substitution treatments just relieve the consequences of dopaminergic neuron loss. Increasing evidence points to peripheral T lymphocytes as key players in PD, and recently there has been growing interest into the specific role of T helper (Th) 17 lymphocytes. Th17 are a proinflammatory CD4+ T cell lineage named after interleukin (IL)-17, the main cytokine produced by these cells. Th17 are involved in immune-related disease such as psoriasis, rheumatoid arthritis and inflammatory bowel disease, and drugs targeting Th17/IL-17 are currently approved for clinical use in such disease. In the present paper, we first summarized current knowledge about contribution of the peripheral immune system in PD, as well as about the physiopharmacology of Th17 and IL-17 together with its therapeutic relevance. Thereafter, we systematically retrieved and evaluated published evidence about Th17 and IL-17 in PD, to help assessing Th17/IL-17-targeting drugs as potentially novel antiparkinson agents. Critical appraisal of the evidence did not allow to reach definite conclusions: both animal as well as clinical studies are limited, just a few provide mechanistic evidence and none of them investigates the eventual relationship between Th17/IL-17 and clinically relevant endpoints such as disease progression, disability scores, intensity of dopaminergic substitution treatment. Careful assessment of Th17 in PD is anyway a priority, as Th17/IL-17-targeting therapeutics might represent a straightforward opportunity for the unmet needs of PD patients." @default.
• W2911851957 created "2019-02-21" @default.
• W2911851957 creator A5004872259 @default.
• W2911851957 creator A5016105444 @default.
• W2911851957 creator A5067993204 @default.
• W2911851957 creator A5073758149 @default.
• W2911851957 creator A5078292988 @default.
• W2911851957 date "2019-01-24" @default.
• W2911851957 modified "2023-10-14" @default.
• W2911851957 title "Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence" @default.
• W2911851957 cites W116302275 @default.
• W2911851957 cites W1493141693 @default.
• W2911851957 cites W1535842809 @default.
• W2911851957 cites W1538907359 @default.
• W2911851957 cites W1546232808 @default.
• W2911851957 cites W1546942081 @default.
• W2911851957 cites W1551727579 @default.
• W2911851957 cites W1581564829 @default.
• W2911851957 cites W1614500582 @default.
• W2911851957 cites W1758745343 @default.
• W2911851957 cites W1874066939 @default.
• W2911851957 cites W1924258068 @default.
• W2911851957 cites W1934236512 @default.
• W2911851957 cites W1965088828 @default.
• W2911851957 cites W1967640115 @default.
• W2911851957 cites W1969184610 @default.
• W2911851957 cites W1976173775 @default.
• W2911851957 cites W1983885843 @default.
• W2911851957 cites W1984390733 @default.
• W2911851957 cites W1992220976 @default.
• W2911851957 cites W1992819367 @default.
• W2911851957 cites W1993273784 @default.
• W2911851957 cites W1994752152 @default.
• W2911851957 cites W1998895238 @default.
• W2911851957 cites W2001283049 @default.
• W2911851957 cites W2003129702 @default.
• W2911851957 cites W2005155108 @default.
• W2911851957 cites W2005501262 @default.
• W2911851957 cites W2006428939 @default.
• W2911851957 cites W2008086119 @default.
• W2911851957 cites W2008512592 @default.
• W2911851957 cites W2010597200 @default.
• W2911851957 cites W2015347941 @default.
• W2911851957 cites W2017929603 @default.
• W2911851957 cites W2020233428 @default.
• W2911851957 cites W2023729916 @default.
• W2911851957 cites W2024490058 @default.
• W2911851957 cites W2026527347 @default.
• W2911851957 cites W2028978359 @default.
• W2911851957 cites W2033655746 @default.
• W2911851957 cites W2036600670 @default.
• W2911851957 cites W2046041427 @default.
• W2911851957 cites W2049329367 @default.
• W2911851957 cites W2052998574 @default.
• W2911851957 cites W2053180614 @default.
• W2911851957 cites W2055712900 @default.
• W2911851957 cites W2058487327 @default.
• W2911851957 cites W2058522899 @default.
• W2911851957 cites W2062913544 @default.
• W2911851957 cites W2063323081 @default.
• W2911851957 cites W2070265035 @default.
• W2911851957 cites W2072787449 @default.
• W2911851957 cites W2072863782 @default.
• W2911851957 cites W2073845471 @default.
• W2911851957 cites W2074149787 @default.
• W2911851957 cites W2074869406 @default.
• W2911851957 cites W2076333673 @default.
• W2911851957 cites W2082040247 @default.
• W2911851957 cites W2082510957 @default.
• W2911851957 cites W2084388036 @default.
• W2911851957 cites W2085270307 @default.
• W2911851957 cites W2086710802 @default.
• W2911851957 cites W2086816316 @default.
• W2911851957 cites W2088218392 @default.
• W2911851957 cites W2089449750 @default.
• W2911851957 cites W2089574993 @default.
• W2911851957 cites W2093897672 @default.
• W2911851957 cites W2097830904 @default.
• W2911851957 cites W2097998535 @default.
• W2911851957 cites W2100693719 @default.
• W2911851957 cites W2102618449 @default.
• W2911851957 cites W2106350754 @default.
• W2911851957 cites W2113561458 @default.
• W2911851957 cites W2114468018 @default.
• W2911851957 cites W2118889444 @default.
• W2911851957 cites W2120729572 @default.
• W2911851957 cites W2123093300 @default.
• W2911851957 cites W2126742635 @default.
• W2911851957 cites W2128792706 @default.
• W2911851957 cites W2134860024 @default.
• W2911851957 cites W2136879071 @default.
• W2911851957 cites W2137303237 @default.
• W2911851957 cites W2139130148 @default.
• W2911851957 cites W2139908772 @default.
• W2911851957 cites W2144013613 @default.
• W2911851957 cites W2144618115 @default.
• W2911851957 cites W2151966368 @default.
• W2911851957 cites W2152014155 @default.
• W2911851957 cites W2155737332 @default.
• W2911851957 cites W2155779547 @default.

• next