FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911854071> ?p ?o ?g. }

• W2911854071 endingPage "2317" @default.
• W2911854071 startingPage "2312" @default.
• W2911854071 abstract "Significance CD8 + T lymphocytes, which are typically devoted to eliminate malignant and infected cells, have been described in the central nervous system (CNS) of patients and mice with amyotrophic lateral sclerosis (ALS). However, their role in ALS pathogenesis has yet to be unraveled. Here, we show that ablation of CD8 + T cells in ALS mice increased the number of surviving motoneurons. CD8 + T cells expressing the ALS-causing superoxide dismutase-1 mutant protein recognize and selectively kill motoneurons in vitro. To exert their cytotoxic function, mutant CD8 + T cells required presentation of the antigen-MHC-I complex at the surface of the motoneurons. Analysis of T cell receptor diversity supports the evidence that self-reactive CD8 + T lymphocytes infiltrate the CNS of ALS mice to exert cytotoxic function." @default.
• W2911854071 created "2019-02-21" @default.
• W2911854071 creator A5004386868 @default.
• W2911854071 creator A5009332522 @default.
• W2911854071 creator A5010171634 @default.
• W2911854071 creator A5010541785 @default.
• W2911854071 creator A5014217081 @default.
• W2911854071 creator A5015101274 @default.
• W2911854071 creator A5026593440 @default.
• W2911854071 creator A5035207277 @default.
• W2911854071 creator A5046013413 @default.
• W2911854071 creator A5047597639 @default.
• W2911854071 creator A5050843259 @default.
• W2911854071 creator A5056952886 @default.
• W2911854071 creator A5059920630 @default.
• W2911854071 creator A5064342215 @default.
• W2911854071 creator A5067772308 @default.
• W2911854071 creator A5074176832 @default.
• W2911854071 creator A5074325352 @default.
• W2911854071 creator A5079629771 @default.
• W2911854071 creator A5080363903 @default.
• W2911854071 creator A5084101524 @default.
• W2911854071 creator A5088910551 @default.
• W2911854071 date "2019-01-23" @default.
• W2911854071 modified "2023-10-17" @default.
• W2911854071 title "Cytotoxic CD8⁺T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons" @default.
• W2911854071 cites W1552106782 @default.
• W2911854071 cites W1589224876 @default.
• W2911854071 cites W1964766831 @default.
• W2911854071 cites W1976266513 @default.
• W2911854071 cites W1979285653 @default.
• W2911854071 cites W1986697483 @default.
• W2911854071 cites W1998975866 @default.
• W2911854071 cites W2003323514 @default.
• W2911854071 cites W2007664874 @default.
• W2911854071 cites W2008299115 @default.
• W2911854071 cites W2010003461 @default.
• W2911854071 cites W2013806798 @default.
• W2911854071 cites W2015437828 @default.
• W2911854071 cites W2021168188 @default.
• W2911854071 cites W2025366797 @default.
• W2911854071 cites W2033344638 @default.
• W2911854071 cites W2038555363 @default.
• W2911854071 cites W2045909419 @default.
• W2911854071 cites W2047606959 @default.
• W2911854071 cites W2068384792 @default.
• W2911854071 cites W2068874043 @default.
• W2911854071 cites W2069781018 @default.
• W2911854071 cites W2080209477 @default.
• W2911854071 cites W2087244840 @default.
• W2911854071 cites W2090615318 @default.
• W2911854071 cites W2092168876 @default.
• W2911854071 cites W2095685454 @default.
• W2911854071 cites W2112211557 @default.
• W2911854071 cites W2120518061 @default.
• W2911854071 cites W2123848058 @default.
• W2911854071 cites W2127769185 @default.
• W2911854071 cites W2144475886 @default.
• W2911854071 cites W2149542236 @default.
• W2911854071 cites W2155921007 @default.
• W2911854071 cites W2165721042 @default.
• W2911854071 cites W2165863447 @default.
• W2911854071 cites W2165871546 @default.
• W2911854071 cites W2290753804 @default.
• W2911854071 cites W2293892300 @default.
• W2911854071 cites W2594565722 @default.
• W2911854071 cites W2691635485 @default.
• W2911854071 cites W2735466792 @default.
• W2911854071 cites W2799753096 @default.
• W2911854071 cites W2887947540 @default.
• W2911854071 doi "https://doi.org/10.1073/pnas.1815961116" @default.
• W2911854071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369778" @default.
• W2911854071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674678" @default.
• W2911854071 hasPublicationYear "2019" @default.
• W2911854071 type Work @default.
• W2911854071 sameAs 2911854071 @default.
• W2911854071 citedByCount "74" @default.
• W2911854071 countsByYear W29118540712019 @default.
• W2911854071 countsByYear W29118540712020 @default.
• W2911854071 countsByYear W29118540712021 @default.
• W2911854071 countsByYear W29118540712022 @default.
• W2911854071 countsByYear W29118540712023 @default.
• W2911854071 crossrefType "journal-article" @default.
• W2911854071 hasAuthorship W2911854071A5004386868 @default.
• W2911854071 hasAuthorship W2911854071A5009332522 @default.
• W2911854071 hasAuthorship W2911854071A5010171634 @default.
• W2911854071 hasAuthorship W2911854071A5010541785 @default.
• W2911854071 hasAuthorship W2911854071A5014217081 @default.
• W2911854071 hasAuthorship W2911854071A5015101274 @default.
• W2911854071 hasAuthorship W2911854071A5026593440 @default.
• W2911854071 hasAuthorship W2911854071A5035207277 @default.
• W2911854071 hasAuthorship W2911854071A5046013413 @default.
• W2911854071 hasAuthorship W2911854071A5047597639 @default.
• W2911854071 hasAuthorship W2911854071A5050843259 @default.
• W2911854071 hasAuthorship W2911854071A5056952886 @default.
• W2911854071 hasAuthorship W2911854071A5059920630 @default.
• W2911854071 hasAuthorship W2911854071A5064342215 @default.
• W2911854071 hasAuthorship W2911854071A5067772308 @default.

• next