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- W2911864427 endingPage "1414" @default.
- W2911864427 startingPage "1406" @default.
- W2911864427 abstract "Abstract Cells and the molecular processes underlying their behavior are highly dynamic. Understanding these dynamic biological processes requires noninvasive continuous quantitative single-cell observations, instead of population-based average or single-cell snapshot analysis. Ideally, single-cell dynamics are measured long-term in vivo; however, despite progress in recent years, technical limitations still prevent such studies. On the other hand, in vitro studies have proven to be useful for answering long-standing questions. Although technically still demanding, long-term single-cell imaging and tracking in vitro have become valuable tools to elucidate dynamic molecular processes and mechanisms, especially in rare and heterogeneous populations. Here, we review how continuous quantitative single-cell imaging of hematopoietic cells has been used to solve decades-long controversies. Because aberrant cell fate decisions are at the heart of tissue degeneration and disease, we argue that studying their molecular dynamics using quantitative single-cell imaging will also improve our understanding of these processes and lead to new strategies for therapies." @default.
- W2911864427 created "2019-02-21" @default.
- W2911864427 creator A5022038247 @default.
- W2911864427 creator A5087508483 @default.
- W2911864427 date "2019-03-28" @default.
- W2911864427 modified "2023-10-05" @default.
- W2911864427 title "Understanding cell fate control by continuous single-cell quantification" @default.
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