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• W2911883905 abstract "Summary The mqsRA operon encodes a toxin–antitoxin pair that was characterized to participate in biofilm and persister cell formation in Escherichia coli . Notably, the antitoxin MqsA possesses a C‐terminal DNA‐binding domain that recognizes the [5’‐AACCT(N) 2‐4 AGGTT‐3′] motif and acts as a transcriptional regulator controlling multiple genes including the general stress response regulator RpoS. However, it is unknown how the transcriptional circuits of MqsA homologues have changed in bacteria over evolutionary time. Here, we found mqsA in Pseudomonas fluorescens ( PfmqsA ) is acquired through horizontal gene transfer and binds to a slightly different motif [5′‐TACCCT(N) 3 AGGGTA‐3′], which exists upstream of the PfmqsRA operon. Interestingly, an adjacent GntR‐type transcriptional regulator, which was termed AgtR, is under negative control of PfMqsA. It was further demonstrated that PfMqsA reduces production of biofilm components through AgtR, which directly regulates the pga and fap operons involved in the synthesis of extracellular polymeric substances. Moreover, through quantitative proteomics analysis, we showed AgtR is a highly pleiotropic regulator that influences up to 252 genes related to diverse processes including chemotaxis, oxidative phosphorylation and carbon and nitrogen metabolism. Taken together, our findings suggest the rewired regulatory circuit of PfMqsA influences diverse physiological aspects of P. fluorescens 2P24 via the newly characterized AgtR." @default.
• W2911883905 created "2019-02-21" @default.
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• W2911883905 date "2019-03-21" @default.
• W2911883905 modified "2023-10-17" @default.
• W2911883905 title "The antitoxin MqsA homologue in <scp><i>Pseudomonas fluorescens</i></scp> 2P24 has a rewired regulatory circuit through evolution" @default.
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• W2911883905 doi "https://doi.org/10.1111/1462-2920.14538" @default.
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• W2911883905 hasPublicationYear "2019" @default.
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