FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911887615> ?p ?o ?g. }

• W2911887615 endingPage "809" @default.
• W2911887615 startingPage "809" @default.
• W2911887615 abstract "MicroRNA (miRNA) is small RNA of 20 to 22 nucleotides in length and is stably present in plasma. Regulating the expression of miRNA taken into cells has been suggested as a general therapeutic approach. We identified the novel anti-inflammatory miRNA hsa-miR-766-3p and investigated its biological function in human rheumatoid arthritis (RA) fibroblast-like synoviocyte MH7A cells. To verify the function of the miRNA present in the plasma of RA patients, we performed a comprehensive analysis of the miRNA expression during abatacept treatment and identified eight miRNAs with significantly altered expression levels. Among these eight miRNAs, miR-766-3p was found to have a clear function. The expression of inflammatory genes in response to inflammatory stimuli was suppressed in MH7A transduced with miR-766-3p. We showed that miR-766-3p indirectly reduced the activation of NF-κB and clarified that this mechanism was partially involved in the reduction of the mineralocorticoid receptor expression. In addition, the inflammatory responses were suppressed in other types of cells. These results indicate the novel function of miR-766-3p, findings that may aid in the development of therapies to suppress inflammation, not only in RA but also in other diseases." @default.
• W2911887615 created "2019-02-21" @default.
• W2911887615 creator A5010617996 @default.
• W2911887615 creator A5014821521 @default.
• W2911887615 creator A5023318918 @default.
• W2911887615 creator A5027538445 @default.
• W2911887615 creator A5029250115 @default.
• W2911887615 creator A5034991389 @default.
• W2911887615 creator A5048504310 @default.
• W2911887615 creator A5050835989 @default.
• W2911887615 creator A5066124663 @default.
• W2911887615 creator A5069901821 @default.
• W2911887615 date "2019-02-14" @default.
• W2911887615 modified "2023-10-16" @default.
• W2911887615 title "MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling" @default.
• W2911887615 cites W1132440873 @default.
• W2911887615 cites W1486629589 @default.
• W2911887615 cites W1788337094 @default.
• W2911887615 cites W1972909901 @default.
• W2911887615 cites W1973137505 @default.
• W2911887615 cites W1984192201 @default.
• W2911887615 cites W2003902924 @default.
• W2911887615 cites W2023709564 @default.
• W2911887615 cites W2031272027 @default.
• W2911887615 cites W2033753616 @default.
• W2911887615 cites W2034722418 @default.
• W2911887615 cites W2037248666 @default.
• W2911887615 cites W2041551098 @default.
• W2911887615 cites W2050804496 @default.
• W2911887615 cites W2061851373 @default.
• W2911887615 cites W2070840570 @default.
• W2911887615 cites W2075752921 @default.
• W2911887615 cites W2093478617 @default.
• W2911887615 cites W2101895473 @default.
• W2911887615 cites W2108234931 @default.
• W2911887615 cites W2115093090 @default.
• W2911887615 cites W2124446420 @default.
• W2911887615 cites W2127867654 @default.
• W2911887615 cites W2172428598 @default.
• W2911887615 cites W2296525683 @default.
• W2911887615 cites W2560140530 @default.
• W2911887615 cites W2588757737 @default.
• W2911887615 cites W2699220065 @default.
• W2911887615 cites W2742677820 @default.
• W2911887615 cites W2766293234 @default.
• W2911887615 cites W2780558495 @default.
• W2911887615 cites W2782295049 @default.
• W2911887615 cites W2888070171 @default.
• W2911887615 cites W2892283506 @default.
• W2911887615 doi "https://doi.org/10.3390/ijms20040809" @default.
• W2911887615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413049" @default.
• W2911887615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30769772" @default.
• W2911887615 hasPublicationYear "2019" @default.
• W2911887615 type Work @default.
• W2911887615 sameAs 2911887615 @default.
• W2911887615 citedByCount "33" @default.
• W2911887615 countsByYear W29118876152019 @default.
• W2911887615 countsByYear W29118876152020 @default.
• W2911887615 countsByYear W29118876152021 @default.
• W2911887615 countsByYear W29118876152022 @default.
• W2911887615 countsByYear W29118876152023 @default.
• W2911887615 crossrefType "journal-article" @default.
• W2911887615 hasAuthorship W2911887615A5010617996 @default.
• W2911887615 hasAuthorship W2911887615A5014821521 @default.
• W2911887615 hasAuthorship W2911887615A5023318918 @default.
• W2911887615 hasAuthorship W2911887615A5027538445 @default.
• W2911887615 hasAuthorship W2911887615A5029250115 @default.
• W2911887615 hasAuthorship W2911887615A5034991389 @default.
• W2911887615 hasAuthorship W2911887615A5048504310 @default.
• W2911887615 hasAuthorship W2911887615A5050835989 @default.
• W2911887615 hasAuthorship W2911887615A5066124663 @default.
• W2911887615 hasAuthorship W2911887615A5069901821 @default.
• W2911887615 hasBestOaLocation W29118876151 @default.
• W2911887615 hasConcept C104317684 @default.
• W2911887615 hasConcept C14036430 @default.
• W2911887615 hasConcept C145059251 @default.
• W2911887615 hasConcept C170493617 @default.
• W2911887615 hasConcept C189135053 @default.
• W2911887615 hasConcept C203014093 @default.
• W2911887615 hasConcept C2776914184 @default.
• W2911887615 hasConcept C2777575956 @default.
• W2911887615 hasConcept C2777730290 @default.
• W2911887615 hasConcept C2779338263 @default.
• W2911887615 hasConcept C2779341050 @default.
• W2911887615 hasConcept C2779605438 @default.
• W2911887615 hasConcept C2780653079 @default.
• W2911887615 hasConcept C502942594 @default.
• W2911887615 hasConcept C54355233 @default.
• W2911887615 hasConcept C62478195 @default.
• W2911887615 hasConcept C86803240 @default.
• W2911887615 hasConcept C95444343 @default.
• W2911887615 hasConceptScore W2911887615C104317684 @default.
• W2911887615 hasConceptScore W2911887615C14036430 @default.
• W2911887615 hasConceptScore W2911887615C145059251 @default.
• W2911887615 hasConceptScore W2911887615C170493617 @default.
• W2911887615 hasConceptScore W2911887615C189135053 @default.
• W2911887615 hasConceptScore W2911887615C203014093 @default.
• W2911887615 hasConceptScore W2911887615C2776914184 @default.

• next