FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911917386> ?p ?o ?g. }

• W2911917386 endingPage "447" @default.
• W2911917386 startingPage "433" @default.
• W2911917386 abstract "Abstract The immune system is capable of making antibodies against anything that is foreign, yet it does not react against components of self. In that sense, a fundamental requirement of the body's immune defense is specificity. Remarkably, this ability to specifically attack foreign antigens is directed even against antigens that have not been encountered a priori by the immune system. The specificity of an antibody for the foreign antigen evolves through an iterative process of somatic mutations followed by selection. There is, however, accumulating evidence that the antibodies are often functionally promiscuous or multi-specific which can lead to their binding to more than one antigen. An important cause of antibody cross-reactivity is molecular mimicry. Molecular mimicry has been implicated in the generation of autoimmune response. When foreign antigen shares similarity with the component of self, the antibodies generated could result in an autoimmune response. The focus of this review is to capture the contrast between specificity and promiscuity and the structural mechanisms employed by the antibodies to accomplish promiscuity, at the molecular level. The conundrum between the specificity of the immune system for foreign antigens on the one hand and the multi-reactivity of the antibody on the other has been addressed. Antibody specificity in the context of the rapid evolution of the antigenic determinants and molecular mimicry displayed by antigens are also discussed." @default.
• W2911917386 created "2019-02-21" @default.
• W2911917386 creator A5037280953 @default.
• W2911917386 creator A5049659243 @default.
• W2911917386 date "2019-02-05" @default.
• W2911917386 modified "2023-09-27" @default.
• W2911917386 title "Antibody specificity and promiscuity" @default.
• W2911917386 cites W1500361889 @default.
• W2911917386 cites W1566160871 @default.
• W2911917386 cites W1567286786 @default.
• W2911917386 cites W1567888165 @default.
• W2911917386 cites W1592986776 @default.
• W2911917386 cites W1599651984 @default.
• W2911917386 cites W1618300663 @default.
• W2911917386 cites W1697183872 @default.
• W2911917386 cites W1846318147 @default.
• W2911917386 cites W1858317139 @default.
• W2911917386 cites W1872459230 @default.
• W2911917386 cites W1936038771 @default.
• W2911917386 cites W1966356705 @default.
• W2911917386 cites W1971715214 @default.
• W2911917386 cites W1978090240 @default.
• W2911917386 cites W1981981290 @default.
• W2911917386 cites W1987950132 @default.
• W2911917386 cites W1989057973 @default.
• W2911917386 cites W1992106533 @default.
• W2911917386 cites W1992625839 @default.
• W2911917386 cites W1992743196 @default.
• W2911917386 cites W1997875463 @default.
• W2911917386 cites W2000263897 @default.
• W2911917386 cites W2005911699 @default.
• W2911917386 cites W2007054796 @default.
• W2911917386 cites W2011352576 @default.
• W2911917386 cites W2012942903 @default.
• W2911917386 cites W2014011416 @default.
• W2911917386 cites W2015802360 @default.
• W2911917386 cites W2016333231 @default.
• W2911917386 cites W2016337723 @default.
• W2911917386 cites W2023224232 @default.
• W2911917386 cites W2024772565 @default.
• W2911917386 cites W2024972268 @default.
• W2911917386 cites W2026210802 @default.
• W2911917386 cites W2031120162 @default.
• W2911917386 cites W2036483423 @default.
• W2911917386 cites W2039484130 @default.
• W2911917386 cites W2040009096 @default.
• W2911917386 cites W2040570036 @default.
• W2911917386 cites W2041374621 @default.
• W2911917386 cites W2041957907 @default.
• W2911917386 cites W2042847778 @default.
• W2911917386 cites W2044414242 @default.
• W2911917386 cites W2047658919 @default.
• W2911917386 cites W2049886753 @default.
• W2911917386 cites W2051710717 @default.
• W2911917386 cites W2053819767 @default.
• W2911917386 cites W2056667374 @default.
• W2911917386 cites W2061538346 @default.
• W2911917386 cites W2063109965 @default.
• W2911917386 cites W2067030637 @default.
• W2911917386 cites W2067920323 @default.
• W2911917386 cites W2072854137 @default.
• W2911917386 cites W2073519961 @default.
• W2911917386 cites W2075426113 @default.
• W2911917386 cites W2075836559 @default.
• W2911917386 cites W2076377437 @default.
• W2911917386 cites W2076812487 @default.
• W2911917386 cites W2079290149 @default.
• W2911917386 cites W2079564333 @default.
• W2911917386 cites W2080971574 @default.
• W2911917386 cites W2082660881 @default.
• W2911917386 cites W2086613923 @default.
• W2911917386 cites W2087438783 @default.
• W2911917386 cites W2088026556 @default.
• W2911917386 cites W2088563323 @default.
• W2911917386 cites W2091174247 @default.
• W2911917386 cites W2093504415 @default.
• W2911917386 cites W2095398138 @default.
• W2911917386 cites W2096013468 @default.
• W2911917386 cites W2097303612 @default.
• W2911917386 cites W2098785227 @default.
• W2911917386 cites W2102640264 @default.
• W2911917386 cites W2103077855 @default.
• W2911917386 cites W2106306111 @default.
• W2911917386 cites W2108975697 @default.
• W2911917386 cites W2110036226 @default.
• W2911917386 cites W2113521438 @default.
• W2911917386 cites W2120646408 @default.
• W2911917386 cites W2121221840 @default.
• W2911917386 cites W2123539477 @default.
• W2911917386 cites W2123880827 @default.
• W2911917386 cites W2125682786 @default.
• W2911917386 cites W2128312954 @default.
• W2911917386 cites W2131849805 @default.
• W2911917386 cites W2135792930 @default.
• W2911917386 cites W2139295688 @default.
• W2911917386 cites W2141769722 @default.
• W2911917386 cites W2142575954 @default.
• W2911917386 cites W2143033111 @default.

• next