FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911921345> ?p ?o ?g. }

• W2911921345 endingPage "7" @default.
• W2911921345 startingPage "1" @default.
• W2911921345 abstract "Background: Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes. The aim of this review is to determine the potentially utility of cannabinoids in the treatment of pancreatic cancer. Methods: A literature review focused on the biological effects of cannabinoids in cancer treatment, with a focus on pancreatic cancer, was conducted. In vitro and in vivo studies that investigated the effects of cannabinoids in pancreatic cancer were identified and potential mechanisms of action were assessed. Results: Cannabinol receptors have been identified in pancreatic cancer with several studies showing in vitro antiproliferative and proapoptotic effects. The main active substances found in cannabis plants are cannabidiol (CBD) and tetrahydrocannabinol (THC). There effects are predominately mediated through, but not limited to cannabinoid receptor-1, cannabinoid receptor-2, and G-protein-coupled receptor 55 pathways. In vitro studies consistently demonstrated tumor growth-inhibiting effects with CBD, THC, and synthetic derivatives. Synergistic treatment effects have been shown in two studies with the combination of CBD/synthetic cannabinoid receptor ligands and chemotherapy in xenograft and genetically modified spontaneous pancreatic cancer models. There are, however, no clinical studies to date showing treatment benefits in patients with pancreatic cancer. Conclusions: Cannabinoids may be an effective adjunct for the treatment of pancreatic cancer. Data on the anticancer effectiveness of various cannabinoid formulations, treatment dosing, precise mode of action, and clinical studies are lacking." @default.
• W2911921345 created "2019-02-21" @default.
• W2911921345 creator A5022302377 @default.
• W2911921345 creator A5029339790 @default.
• W2911921345 creator A5047671035 @default.
• W2911921345 date "2019-01-01" @default.
• W2911921345 modified "2023-09-27" @default.
• W2911921345 title "Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer" @default.
• W2911921345 cites W1495416276 @default.
• W2911921345 cites W1753419471 @default.
• W2911921345 cites W1965087543 @default.
• W2911921345 cites W1966551238 @default.
• W2911921345 cites W1967319651 @default.
• W2911921345 cites W1967942903 @default.
• W2911921345 cites W1968812902 @default.
• W2911921345 cites W1977651719 @default.
• W2911921345 cites W1979368453 @default.
• W2911921345 cites W1983563948 @default.
• W2911921345 cites W1986360066 @default.
• W2911921345 cites W1990006357 @default.
• W2911921345 cites W1990694709 @default.
• W2911921345 cites W1996177366 @default.
• W2911921345 cites W1996629211 @default.
• W2911921345 cites W2001036106 @default.
• W2911921345 cites W2002535987 @default.
• W2911921345 cites W2008225047 @default.
• W2911921345 cites W2013093033 @default.
• W2911921345 cites W2013655484 @default.
• W2911921345 cites W2016371428 @default.
• W2911921345 cites W2038809664 @default.
• W2911921345 cites W2039716354 @default.
• W2911921345 cites W2049370911 @default.
• W2911921345 cites W2050601193 @default.
• W2911921345 cites W2061601726 @default.
• W2911921345 cites W2062300012 @default.
• W2911921345 cites W2067927629 @default.
• W2911921345 cites W2075560989 @default.
• W2911921345 cites W2081040408 @default.
• W2911921345 cites W2083438158 @default.
• W2911921345 cites W2083859343 @default.
• W2911921345 cites W2089039955 @default.
• W2911921345 cites W2101233587 @default.
• W2911921345 cites W2101599025 @default.
• W2911921345 cites W2103111367 @default.
• W2911921345 cites W2103826070 @default.
• W2911921345 cites W2108265345 @default.
• W2911921345 cites W2112755850 @default.
• W2911921345 cites W2113777848 @default.
• W2911921345 cites W2121330267 @default.
• W2911921345 cites W2124248227 @default.
• W2911921345 cites W2125104309 @default.
• W2911921345 cites W2133702956 @default.
• W2911921345 cites W2134627852 @default.
• W2911921345 cites W2136729555 @default.
• W2911921345 cites W2140705385 @default.
• W2911921345 cites W2142969660 @default.
• W2911921345 cites W2146546493 @default.
• W2911921345 cites W2149183149 @default.
• W2911921345 cites W2154901456 @default.
• W2911921345 cites W2158197340 @default.
• W2911921345 cites W2159319600 @default.
• W2911921345 cites W2164515307 @default.
• W2911921345 cites W2168111104 @default.
• W2911921345 cites W2249337454 @default.
• W2911921345 cites W22941959 @default.
• W2911921345 cites W2305988154 @default.
• W2911921345 cites W2341838858 @default.
• W2911921345 cites W2528162264 @default.
• W2911921345 cites W2531214067 @default.
• W2911921345 cites W2548760197 @default.
• W2911921345 cites W2565318735 @default.
• W2911921345 cites W2565813493 @default.
• W2911921345 cites W2693016255 @default.
• W2911921345 cites W2755174591 @default.
• W2911921345 cites W2765600991 @default.
• W2911921345 cites W2788208686 @default.
• W2911921345 cites W2792848996 @default.
• W2911921345 cites W2800242435 @default.
• W2911921345 cites W2801807973 @default.
• W2911921345 cites W2806235651 @default.
• W2911921345 cites W2884803754 @default.
• W2911921345 cites W4242988300 @default.
• W2911921345 cites W4253742045 @default.
• W2911921345 cites W72042338 @default.
• W2911921345 doi "https://doi.org/10.1089/pancan.2018.0019" @default.
• W2911921345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6352507" @default.
• W2911921345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706048" @default.
• W2911921345 hasPublicationYear "2019" @default.
• W2911921345 type Work @default.
• W2911921345 sameAs 2911921345 @default.
• W2911921345 citedByCount "29" @default.
• W2911921345 countsByYear W29119213452019 @default.
• W2911921345 countsByYear W29119213452020 @default.
• W2911921345 countsByYear W29119213452021 @default.
• W2911921345 countsByYear W29119213452022 @default.
• W2911921345 countsByYear W29119213452023 @default.
• W2911921345 crossrefType "journal-article" @default.
• W2911921345 hasAuthorship W2911921345A5022302377 @default.

• next