Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911969744> ?p ?o ?g. }
- W2911969744 abstract "Diffuse midline gliomas harboring the H3 K27M mutation—including diffuse intrinsic pontine glioma (DIPG)—are lethal high-grade pediatric brain tumors that are inoperable and without cure. Despite numerous clinical trials, DIPG prognosis remains poor, with a median survival of approximately one year from diagnosis. Systemic administration of chemotherapeutic agents is often hindered by the blood brain barrier (BBB), and even drugs that successfully cross the barrier may suffer from unpredictable distributions. The challenge in treating this deadly disease relies on effective delivery of a therapeutic agent to the bulk tumor as well as infiltrating cells. Therefore, methods that can enhance drug delivery to the brain are of great interest. Convection-enhanced delivery (CED) is a strategy that bypasses the BBB entirely and enhances drug distribution by applying hydraulic pressure to deliver agents directly and evenly into a target region. This technique reliably distributes infusate homogenously through the interstitial space of the target region and achieves high local drug concentrations in the brain. Moreover, recent studies have also shown that continuous delivery of drug over an extended period of time is safe, feasible, and more efficacious than standard single session CED. Therefore, CED represents a promising technique for treating DIPG tumors." @default.
- W2911969744 created "2019-02-21" @default.
- W2911969744 creator A5022053658 @default.
- W2911969744 creator A5027180501 @default.
- W2911969744 creator A5066599847 @default.
- W2911969744 date "2019-02-08" @default.
- W2911969744 modified "2023-10-18" @default.
- W2911969744 title "Treatment Strategies in Diffuse Midline Gliomas With the H3K27M Mutation: The Role of Convection-Enhanced Delivery in Overcoming Anatomic Challenges" @default.
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- W2911969744 doi "https://doi.org/10.3389/fonc.2019.00031" @default.
- W2911969744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6375835" @default.
- W2911969744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30800634" @default.