Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911976260> ?p ?o ?g. }
- W2911976260 endingPage "252" @default.
- W2911976260 startingPage "235" @default.
- W2911976260 abstract "Proteomics is a powerful tool to study biological systems and is potentially useful in identifying biomarkers for clinical screening and diagnosis, for monitoring treatment, and for exploring pathogenetic mechanisms in autism. Unlike numerous other experimental approaches employed in autism research, there have been few proteomic-based analyses. Herein, we discuss the findings of studies regarding autism that utilized a proteomic approach and review key considerations in sample acquisition, processing, and analysis. Most proteomic studies on autism used blood or other peripheral tissues. Few studies used brain tissue, the main site of biological difference between persons with autism and others. The findings have varied and are not yet replicated. Some showed abnormalities of synaptic proteins or proteins of mitochondrial bioenergetics. Various abnormalities of proteins relating to immune processes and lipid metabolism have also been noted. Whether any of the proteomic differences between autism and control cases are primary or secondary phenomena is currently unclear. Consequently, no definitive biomarkers for autism have been identified, and the pathophysiological insights provided by proteomic studies to date are uncertain in the absence of replication. Based on this body of work and the challenges in using proteomics to study autism, we suggest considerations for future study design. These include attention to subject and specimen inclusion/exclusion criteria, attention to the state of specimens prior to proteomic analysis, and use of a replicate set of specimens. We end by discussing especially promising applications of proteomics in the study of autism pathobiology." @default.
- W2911976260 created "2019-02-21" @default.
- W2911976260 creator A5020774345 @default.
- W2911976260 creator A5082501044 @default.
- W2911976260 creator A5084022283 @default.
- W2911976260 date "2019-01-01" @default.
- W2911976260 modified "2023-10-17" @default.
- W2911976260 title "Proteomic Investigations of Autism Spectrum Disorder: Past Findings, Current Challenges, and Future Prospects" @default.
- W2911976260 cites W1545611403 @default.
- W2911976260 cites W1578833252 @default.
- W2911976260 cites W1785807100 @default.
- W2911976260 cites W1965928109 @default.
- W2911976260 cites W1966547558 @default.
- W2911976260 cites W1970848271 @default.
- W2911976260 cites W1976222552 @default.
- W2911976260 cites W1984971566 @default.
- W2911976260 cites W1987839624 @default.
- W2911976260 cites W1995814341 @default.
- W2911976260 cites W2002012536 @default.
- W2911976260 cites W2011080454 @default.
- W2911976260 cites W2018685944 @default.
- W2911976260 cites W2021238335 @default.
- W2911976260 cites W2030798029 @default.
- W2911976260 cites W2035591542 @default.
- W2911976260 cites W2050756466 @default.
- W2911976260 cites W2055202150 @default.
- W2911976260 cites W2058760936 @default.
- W2911976260 cites W2072325753 @default.
- W2911976260 cites W2078481820 @default.
- W2911976260 cites W2081357922 @default.
- W2911976260 cites W2086696914 @default.
- W2911976260 cites W2092913927 @default.
- W2911976260 cites W2101840039 @default.
- W2911976260 cites W2105696555 @default.
- W2911976260 cites W2118200305 @default.
- W2911976260 cites W2119744986 @default.
- W2911976260 cites W2122037893 @default.
- W2911976260 cites W2130121541 @default.
- W2911976260 cites W2131548572 @default.
- W2911976260 cites W2138924321 @default.
- W2911976260 cites W2146512944 @default.
- W2911976260 cites W2147101924 @default.
- W2911976260 cites W2159252286 @default.
- W2911976260 cites W2161279233 @default.
- W2911976260 cites W2162086760 @default.
- W2911976260 cites W2164707921 @default.
- W2911976260 cites W2171607710 @default.
- W2911976260 cites W2172112531 @default.
- W2911976260 cites W2173873408 @default.
- W2911976260 cites W2186530786 @default.
- W2911976260 cites W2193974133 @default.
- W2911976260 cites W2195835792 @default.
- W2911976260 cites W2226394254 @default.
- W2911976260 cites W2238074407 @default.
- W2911976260 cites W2286983239 @default.
- W2911976260 cites W2292062507 @default.
- W2911976260 cites W2301446452 @default.
- W2911976260 cites W2313734891 @default.
- W2911976260 cites W2325109391 @default.
- W2911976260 cites W2326642470 @default.
- W2911976260 cites W2419397735 @default.
- W2911976260 cites W2464444303 @default.
- W2911976260 cites W2493029085 @default.
- W2911976260 cites W2515862236 @default.
- W2911976260 cites W2519691041 @default.
- W2911976260 cites W2540426790 @default.
- W2911976260 cites W2568523137 @default.
- W2911976260 cites W2581595947 @default.
- W2911976260 cites W2586915541 @default.
- W2911976260 cites W2588655326 @default.
- W2911976260 cites W2589793208 @default.
- W2911976260 cites W2591925290 @default.
- W2911976260 cites W2594540404 @default.
- W2911976260 cites W2595696124 @default.
- W2911976260 cites W2612013282 @default.
- W2911976260 cites W2614349964 @default.
- W2911976260 cites W2615827843 @default.
- W2911976260 cites W2617319335 @default.
- W2911976260 cites W2618182197 @default.
- W2911976260 cites W2730169795 @default.
- W2911976260 cites W2740570637 @default.
- W2911976260 cites W2765768583 @default.
- W2911976260 cites W2766268933 @default.
- W2911976260 cites W2768214603 @default.
- W2911976260 cites W2776887119 @default.
- W2911976260 cites W2782340813 @default.
- W2911976260 cites W2783073782 @default.
- W2911976260 cites W2802562020 @default.
- W2911976260 cites W2808579481 @default.
- W2911976260 cites W2809176836 @default.
- W2911976260 cites W2949285056 @default.
- W2911976260 cites W4210708461 @default.
- W2911976260 cites W2790974901 @default.
- W2911976260 doi "https://doi.org/10.1007/978-3-030-05542-4_12" @default.
- W2911976260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30747426" @default.
- W2911976260 hasPublicationYear "2019" @default.
- W2911976260 type Work @default.
- W2911976260 sameAs 2911976260 @default.