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- W2911978495 abstract "Tetraploidy has long been of interest to both cell and cancer biologists, partly because of its documented role in tumorigenesis. A common model proposes that the extra centrosomes that are typically acquired during tetraploidization are responsible for driving tumorigenesis. However, this model is inconsistent with the observation that tetraploid cells evolved in culture lack extra centrosomes. This observation raises questions about how tetraploid cells evolve and more specifically about the mechanisms(s) underlying centrosome loss. Here, using a combination of fixed cell analysis, live cell imaging, and mathematical modeling, we show that populations of newly formed tetraploid cells rapidly evolve in vitro to retain a near-tetraploid chromosome number while losing the extra centrosomes gained at the time of tetraploidization. This happens through a process of natural selection in which tetraploid cells that inherit a single centrosome during a bipolar division with asymmetric centrosome clustering are favored for long-term survival." @default.
- W2911978495 created "2019-02-21" @default.
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- W2911978495 date "2019-01-21" @default.
- W2911978495 modified "2023-10-17" @default.
- W2911978495 title "Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells" @default.
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- W2911978495 doi "https://doi.org/10.1101/526731" @default.
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