FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911984893> ?p ?o ?g. }

• W2911984893 abstract "The gut microbiota has been linked to various neurological disorders via the gut-brain axis. Diet influences the composition of the gut microbiota. The ketogenic diet (KD) is a high-fat, adequate-protein, low-carbohydrate diet established for treatment of therapy-resistant epilepsy in children. Its efficacy in reducing seizures has been confirmed, but the mechanisms remain elusive. The diet has also shown positive effects in a wide range of other diseases, including Alzheimer's, depression, autism, cancer, and type 2 diabetes. We collected fecal samples from 12 children with therapy-resistant epilepsy before starting KD and after 3 months on the diet. Parents did not start KD and served as diet controls. Applying shotgun metagenomic DNA sequencing, both taxonomic and functional profiles were established. Here we report that alpha diversity is not changed significantly during the diet, but differences in both taxonomic and functional composition are detected. Relative abundance of bifidobacteria as well as E. rectale and Dialister is significantly diminished during the intervention. An increase in relative abundance of E. coli is observed on KD. Functional analysis revealed changes in 29 SEED subsystems including the reduction of seven pathways involved in carbohydrate metabolism. Decomposition of these shifts indicates that bifidobacteria and Escherichia are important contributors to the observed functional shifts. As relative abundance of health-promoting, fiber-consuming bacteria becomes less abundant during KD, we raise concern about the effects of the diet on the gut microbiota and overall health. Further studies need to investigate whether these changes are necessary for the therapeutic effect of KD." @default.
• W2911984893 created "2019-02-21" @default.
• W2911984893 creator A5006437281 @default.
• W2911984893 creator A5022910746 @default.
• W2911984893 creator A5032872874 @default.
• W2911984893 creator A5038152196 @default.
• W2911984893 creator A5040555133 @default.
• W2911984893 creator A5057575937 @default.
• W2911984893 creator A5067539705 @default.
• W2911984893 creator A5067926250 @default.
• W2911984893 creator A5081894725 @default.
• W2911984893 creator A5090320656 @default.
• W2911984893 date "2019-01-23" @default.
• W2911984893 modified "2023-10-17" @default.
• W2911984893 title "The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy" @default.
• W2911984893 cites W1491466025 @default.
• W2911984893 cites W1601466212 @default.
• W2911984893 cites W1703384511 @default.
• W2911984893 cites W1931789414 @default.
• W2911984893 cites W1975332428 @default.
• W2911984893 cites W1981266729 @default.
• W2911984893 cites W1981500982 @default.
• W2911984893 cites W1983050243 @default.
• W2911984893 cites W1987238295 @default.
• W2911984893 cites W1990800885 @default.
• W2911984893 cites W2000981392 @default.
• W2911984893 cites W2023983971 @default.
• W2911984893 cites W2024574474 @default.
• W2911984893 cites W2030500910 @default.
• W2911984893 cites W2036016497 @default.
• W2911984893 cites W2045119680 @default.
• W2911984893 cites W2045204781 @default.
• W2911984893 cites W2048269119 @default.
• W2911984893 cites W2051846981 @default.
• W2911984893 cites W2058062413 @default.
• W2911984893 cites W2062067745 @default.
• W2911984893 cites W2078455937 @default.
• W2911984893 cites W2079183971 @default.
• W2911984893 cites W2087292184 @default.
• W2911984893 cites W2087966568 @default.
• W2911984893 cites W2094647936 @default.
• W2911984893 cites W2099478180 @default.
• W2911984893 cites W2108234281 @default.
• W2911984893 cites W2110256992 @default.
• W2911984893 cites W2114034054 @default.
• W2911984893 cites W2124927293 @default.
• W2911984893 cites W2126051108 @default.
• W2911984893 cites W2128933212 @default.
• W2911984893 cites W2131902769 @default.
• W2911984893 cites W2132929849 @default.
• W2911984893 cites W2133547370 @default.
• W2911984893 cites W2133856765 @default.
• W2911984893 cites W2152200355 @default.
• W2911984893 cites W2153772399 @default.
• W2911984893 cites W2157630710 @default.
• W2911984893 cites W2165008361 @default.
• W2911984893 cites W2165067288 @default.
• W2911984893 cites W2166066205 @default.
• W2911984893 cites W2166562121 @default.
• W2911984893 cites W2172136900 @default.
• W2911984893 cites W2189548068 @default.
• W2911984893 cites W2202496149 @default.
• W2911984893 cites W2259851886 @default.
• W2911984893 cites W232900828 @default.
• W2911984893 cites W2337747100 @default.
• W2911984893 cites W2341056284 @default.
• W2911984893 cites W2400773242 @default.
• W2911984893 cites W2413851935 @default.
• W2911984893 cites W2432815617 @default.
• W2911984893 cites W2552041992 @default.
• W2911984893 cites W2567694658 @default.
• W2911984893 cites W2568684402 @default.
• W2911984893 cites W2574920022 @default.
• W2911984893 cites W2615460620 @default.
• W2911984893 cites W2755991692 @default.
• W2911984893 cites W2766892303 @default.
• W2911984893 cites W2769986190 @default.
• W2911984893 cites W2772229595 @default.
• W2911984893 cites W2780398151 @default.
• W2911984893 cites W2801224684 @default.
• W2911984893 cites W2804460705 @default.
• W2911984893 cites W2805633350 @default.
• W2911984893 cites W2809960745 @default.
• W2911984893 cites W28189098 @default.
• W2911984893 cites W2891215396 @default.
• W2911984893 cites W2949138186 @default.
• W2911984893 doi "https://doi.org/10.1038/s41522-018-0073-2" @default.
• W2911984893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6344533" @default.
• W2911984893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30701077" @default.
• W2911984893 hasPublicationYear "2019" @default.
• W2911984893 type Work @default.
• W2911984893 sameAs 2911984893 @default.
• W2911984893 citedByCount "158" @default.
• W2911984893 countsByYear W29119848932019 @default.
• W2911984893 countsByYear W29119848932020 @default.
• W2911984893 countsByYear W29119848932021 @default.
• W2911984893 countsByYear W29119848932022 @default.
• W2911984893 countsByYear W29119848932023 @default.
• W2911984893 crossrefType "journal-article" @default.
• W2911984893 hasAuthorship W2911984893A5006437281 @default.

• next