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- W2912003199 abstract "Introduction: Little is known on the underlying mechanisms of how arsenic (As) induces non-malignant lung disease. However, emerging evidence from animal studies suggests damage to the epithelium of the lung and modulation of the immune system as plausible modes of action. Methods: We conducted population-based studies to evaluate the association between As exposure, measured in well water and urinary arsenic (UAs), UAs metabolites, and markers of lung epithelial damages and immune function in 35,000 participants in the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, a large cohort exposed to a wide range of arsenic levels (0.1-1,517 µg/L) in their water. In a cross sectional study among never-smokers (N=241), we examined the relationship of the serum level of Clara cell protein (CC16), an alveolar epithelial protein, with arsenic exposure. Results: Overall, we observed an inverse association between As exposure and CC16, particularly in those with arsenical skin lesions [UAs (β=-0.13, p=0.01) and cumulative As exposure (β=-0.045, p=0.05)] in adjusted models. Our analysis also reveals an inverse association between UAs metabolite monomethylarsonic acid (MMA) and CC16 (β=-0.16, p=0.05). In an ongoing study, among never-smokers (N=51) we observed dose dependent suppression of phytohemagglutinin (PHA)-induced peripheral blood mononuclear cell (PBMC) T-cell proliferation with UAs (β=-0.36, p=0.1) and MMA (β=-0.42, p=0.2). Additionally, a number of cytokines (TNFα, IL4, IL6, and IL1β) in the PBMC supernatants were found to be negatively associated with UAs, particularly IL17 (r=-0.92, p=0.02) similar to animal studies. Conclusion: Our findings indicate that As may disrupt epithelium and immune function associated with respiratory outcomes." @default.
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- W2912003199 date "2015-08-20" @default.
- W2912003199 modified "2023-09-27" @default.
- W2912003199 title "Arsenic Exposure, Non-Malignant Respiratory Outcomes And Immune Modulation In The Health Effects Of Arsenic Longitudinal Study (Heals) Cohort" @default.
- W2912003199 doi "https://doi.org/10.1289/isee.2015.2015-1870" @default.
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