Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912003906> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2912003906 abstract "60 Background: DDR mutations are associated with higher neoantigen load and tumor infiltrating lymphocytes, and are a potential biomarker for immunotherapy. We investigated the association of DDR mutations in gastric (GC), esophageal (EC), and gastroesophageal junction (GEJ) cancers with MSI, PD-L1, and TMB, known predictors for immune checkpoint inhibitors. Methods: 20 DDR mutations were tested by Next-Generation Sequencing (NGS) with a 592-gene panel on a total of 1935 (709 EC; 831 GC; 355 GEJ) cancers. TMB was assessed by NGS, MSI by NGS or fragment analysis, and PD-L1 by IHC (22c3 for CPS or SP142). Results: GC had the highest DDR mutation rate compared to EC and GEJ (27% vs. 20%, p = 0.0005 and 17%, p = 0.0002, respectively). MSI-High (MSI-H) was significantly more common in the DDR mutated cohort (DDR-M) compared to non-mutated cancers (18% vs. 1%; p < 0.0001). TMB-High (≥ 10 mutations/megabase [mt/MB]) was higher in DDR-M (35% vs. 21%; p < 0.0001); in DDR-M cohort, GC had the highest TMB compared to DDR-M EC and GEJ (mean: 13.8 vs. 9.4 vs. 10 mt/MB, respectively; p < 0.0001). DDR mutations were more frequent in the PD-L1 combined positive score (CPS) ≥ 50 group than CPS 0 (42.9% vs. 24%; p = 0.037) and CPS 1-9 (42.9% vs. 20.6%; p = 0.005). ARID1A, ATRX, BRCA2, and PTEN were the most prevalent DDR mutations in MSI-H (87%, 31%, 25%, 24%, respectively); ARID1A, ATRX, BRCA2, and PTEN in TMB-High (47%, 7.7%, 6.7%, 6.8%) and ARID1A, BRCA2, RAD50, and WRN in PD-L1 high (CPS ≥ 10) (48.5% vs. 5.2% vs. 2.5% vs. 3.4%). Conclusions: MSI-H, TMB-high and high PD-L1 expression were significantly more prevalent in the DDR-M cohort compared to non-DDR-mutated cancers, most pronounced in GC. Alterations in ARID1A, ATRX, BRCA2, and PTEN were correlated with MSI-H and TMB-high while ARID1A, BRCA2, RAD50, and WRN were correlated with increased PD-L1 expression. Our findings may help identify patients for tailored immunotherapy approaches in future clinical trials." @default.
- W2912003906 created "2019-02-21" @default.
- W2912003906 creator A5000401547 @default.
- W2912003906 creator A5009223406 @default.
- W2912003906 creator A5013245039 @default.
- W2912003906 creator A5021453899 @default.
- W2912003906 creator A5038120683 @default.
- W2912003906 creator A5040325455 @default.
- W2912003906 creator A5045441776 @default.
- W2912003906 creator A5045618241 @default.
- W2912003906 creator A5052385222 @default.
- W2912003906 creator A5053703913 @default.
- W2912003906 creator A5061373605 @default.
- W2912003906 creator A5070721086 @default.
- W2912003906 creator A5072203753 @default.
- W2912003906 creator A5080544645 @default.
- W2912003906 date "2019-02-01" @default.
- W2912003906 modified "2023-10-17" @default.
- W2912003906 title "Association of DNA damage response and repair genes (DDR) mutations and microsatellite instability (MSI), PD-L1 expression, tumor mutational burden (TMB) in gastroesophageal cancers." @default.
- W2912003906 doi "https://doi.org/10.1200/jco.2019.37.4_suppl.60" @default.
- W2912003906 hasPublicationYear "2019" @default.
- W2912003906 type Work @default.
- W2912003906 sameAs 2912003906 @default.
- W2912003906 citedByCount "4" @default.
- W2912003906 countsByYear W29120039062020 @default.
- W2912003906 countsByYear W29120039062021 @default.
- W2912003906 countsByYear W29120039062023 @default.
- W2912003906 crossrefType "journal-article" @default.
- W2912003906 hasAuthorship W2912003906A5000401547 @default.
- W2912003906 hasAuthorship W2912003906A5009223406 @default.
- W2912003906 hasAuthorship W2912003906A5013245039 @default.
- W2912003906 hasAuthorship W2912003906A5021453899 @default.
- W2912003906 hasAuthorship W2912003906A5038120683 @default.
- W2912003906 hasAuthorship W2912003906A5040325455 @default.
- W2912003906 hasAuthorship W2912003906A5045441776 @default.
- W2912003906 hasAuthorship W2912003906A5045618241 @default.
- W2912003906 hasAuthorship W2912003906A5052385222 @default.
- W2912003906 hasAuthorship W2912003906A5053703913 @default.
- W2912003906 hasAuthorship W2912003906A5061373605 @default.
- W2912003906 hasAuthorship W2912003906A5070721086 @default.
- W2912003906 hasAuthorship W2912003906A5072203753 @default.
- W2912003906 hasAuthorship W2912003906A5080544645 @default.
- W2912003906 hasConcept C104317684 @default.
- W2912003906 hasConcept C121608353 @default.
- W2912003906 hasConcept C126322002 @default.
- W2912003906 hasConcept C134935766 @default.
- W2912003906 hasConcept C180754005 @default.
- W2912003906 hasConcept C190283241 @default.
- W2912003906 hasConcept C2777609662 @default.
- W2912003906 hasConcept C2779767149 @default.
- W2912003906 hasConcept C2781273526 @default.
- W2912003906 hasConcept C501734568 @default.
- W2912003906 hasConcept C502942594 @default.
- W2912003906 hasConcept C526805850 @default.
- W2912003906 hasConcept C54355233 @default.
- W2912003906 hasConcept C60748783 @default.
- W2912003906 hasConcept C61320498 @default.
- W2912003906 hasConcept C71924100 @default.
- W2912003906 hasConcept C86554907 @default.
- W2912003906 hasConcept C86803240 @default.
- W2912003906 hasConceptScore W2912003906C104317684 @default.
- W2912003906 hasConceptScore W2912003906C121608353 @default.
- W2912003906 hasConceptScore W2912003906C126322002 @default.
- W2912003906 hasConceptScore W2912003906C134935766 @default.
- W2912003906 hasConceptScore W2912003906C180754005 @default.
- W2912003906 hasConceptScore W2912003906C190283241 @default.
- W2912003906 hasConceptScore W2912003906C2777609662 @default.
- W2912003906 hasConceptScore W2912003906C2779767149 @default.
- W2912003906 hasConceptScore W2912003906C2781273526 @default.
- W2912003906 hasConceptScore W2912003906C501734568 @default.
- W2912003906 hasConceptScore W2912003906C502942594 @default.
- W2912003906 hasConceptScore W2912003906C526805850 @default.
- W2912003906 hasConceptScore W2912003906C54355233 @default.
- W2912003906 hasConceptScore W2912003906C60748783 @default.
- W2912003906 hasConceptScore W2912003906C61320498 @default.
- W2912003906 hasConceptScore W2912003906C71924100 @default.
- W2912003906 hasConceptScore W2912003906C86554907 @default.
- W2912003906 hasConceptScore W2912003906C86803240 @default.
- W2912003906 hasLocation W29120039061 @default.
- W2912003906 hasOpenAccess W2912003906 @default.
- W2912003906 hasPrimaryLocation W29120039061 @default.
- W2912003906 hasRelatedWork W1986500842 @default.
- W2912003906 hasRelatedWork W2012732208 @default.
- W2912003906 hasRelatedWork W2020667072 @default.
- W2912003906 hasRelatedWork W2031030124 @default.
- W2912003906 hasRelatedWork W2033634288 @default.
- W2912003906 hasRelatedWork W2037808674 @default.
- W2912003906 hasRelatedWork W2106543552 @default.
- W2912003906 hasRelatedWork W2120281217 @default.
- W2912003906 hasRelatedWork W2138214273 @default.
- W2912003906 hasRelatedWork W2398138834 @default.
- W2912003906 isParatext "false" @default.
- W2912003906 isRetracted "false" @default.
- W2912003906 magId "2912003906" @default.
- W2912003906 workType "article" @default.