Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912010294> ?p ?o ?g. }
- W2912010294 endingPage "513" @default.
- W2912010294 startingPage "507" @default.
- W2912010294 abstract "OBJECTIVE We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures. RESEARCH DESIGN AND METHODS Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragility fracture; secondary outcomes included time to hip fracture and to clinical spine fracture. Frailty status was measured by a Frailty Index (FI) of deficit accumulation. The Cox model incorporating an interaction term (frailty × diabetes) was used for analyses. RESULTS The analysis included 3,149 (70% women) participants; 138 (60% women) had diabetes. Higher bone mineral density and FI were observed in participants with diabetes compared with control subjects. A significant relationship between the FI and the risk of incident fragility fractures was found, with a hazard ratio (HR) of 1.02 (95% CI 1.01–1.03) and 1.19 (95% CI 1.10–1.33) for per-0.01 and per-0.10 FI increase, respectively. The interaction was also statistically significant (P = 0.018). The HR for per-0.1 increase in the FI was 1.33 for participants with diabetes and 1.19 for those without diabetes if combining the estimate for the FI itself with the estimate from the interaction term. No evidence of interaction between frailty and diabetes was found for risk of hip and clinical spine fractures. CONCLUSIONS Participants with type 2 diabetes were significantly frailer than individuals without diabetes. Frailty increases the risk of fragility fracture and enhances the effect of diabetes on fragility fractures. Particular attention should be paid to diabetes as a risk factor for fragility fractures in those who are frail." @default.
- W2912010294 created "2019-02-21" @default.
- W2912010294 creator A5001027996 @default.
- W2912010294 creator A5003310723 @default.
- W2912010294 creator A5023518828 @default.
- W2912010294 creator A5027489501 @default.
- W2912010294 creator A5029801001 @default.
- W2912010294 creator A5030199838 @default.
- W2912010294 creator A5031982587 @default.
- W2912010294 creator A5036450106 @default.
- W2912010294 creator A5059955804 @default.
- W2912010294 creator A5062747501 @default.
- W2912010294 creator A5064629196 @default.
- W2912010294 creator A5075674266 @default.
- W2912010294 creator A5076795537 @default.
- W2912010294 creator A5085254271 @default.
- W2912010294 date "2019-01-28" @default.
- W2912010294 modified "2023-10-14" @default.
- W2912010294 title "Frailty and Risk of Fractures in Patients With Type 2 Diabetes" @default.
- W2912010294 cites W1784553320 @default.
- W2912010294 cites W1968563442 @default.
- W2912010294 cites W1971296725 @default.
- W2912010294 cites W1972328688 @default.
- W2912010294 cites W1983484286 @default.
- W2912010294 cites W1989950790 @default.
- W2912010294 cites W2000669510 @default.
- W2912010294 cites W2014767809 @default.
- W2912010294 cites W2026173037 @default.
- W2912010294 cites W2030265211 @default.
- W2912010294 cites W2032510917 @default.
- W2912010294 cites W2035203178 @default.
- W2912010294 cites W2044288806 @default.
- W2912010294 cites W2054160662 @default.
- W2912010294 cites W2075995403 @default.
- W2912010294 cites W2089140097 @default.
- W2912010294 cites W2091042653 @default.
- W2912010294 cites W2095439262 @default.
- W2912010294 cites W2095460977 @default.
- W2912010294 cites W2096559845 @default.
- W2912010294 cites W2105092978 @default.
- W2912010294 cites W2125637498 @default.
- W2912010294 cites W2129700906 @default.
- W2912010294 cites W2131962219 @default.
- W2912010294 cites W2141260918 @default.
- W2912010294 cites W2142514031 @default.
- W2912010294 cites W2147642606 @default.
- W2912010294 cites W2150333580 @default.
- W2912010294 cites W2151490779 @default.
- W2912010294 cites W2157048373 @default.
- W2912010294 cites W2212689096 @default.
- W2912010294 cites W2322881075 @default.
- W2912010294 cites W2326644719 @default.
- W2912010294 cites W2508196303 @default.
- W2912010294 cites W2530322313 @default.
- W2912010294 cites W2581333497 @default.
- W2912010294 cites W2796661030 @default.
- W2912010294 cites W2801757483 @default.
- W2912010294 cites W2885709578 @default.
- W2912010294 doi "https://doi.org/10.2337/dc18-1965" @default.
- W2912010294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692240" @default.
- W2912010294 hasPublicationYear "2019" @default.
- W2912010294 type Work @default.
- W2912010294 sameAs 2912010294 @default.
- W2912010294 citedByCount "63" @default.
- W2912010294 countsByYear W29120102942019 @default.
- W2912010294 countsByYear W29120102942020 @default.
- W2912010294 countsByYear W29120102942021 @default.
- W2912010294 countsByYear W29120102942022 @default.
- W2912010294 countsByYear W29120102942023 @default.
- W2912010294 crossrefType "journal-article" @default.
- W2912010294 hasAuthorship W2912010294A5001027996 @default.
- W2912010294 hasAuthorship W2912010294A5003310723 @default.
- W2912010294 hasAuthorship W2912010294A5023518828 @default.
- W2912010294 hasAuthorship W2912010294A5027489501 @default.
- W2912010294 hasAuthorship W2912010294A5029801001 @default.
- W2912010294 hasAuthorship W2912010294A5030199838 @default.
- W2912010294 hasAuthorship W2912010294A5031982587 @default.
- W2912010294 hasAuthorship W2912010294A5036450106 @default.
- W2912010294 hasAuthorship W2912010294A5059955804 @default.
- W2912010294 hasAuthorship W2912010294A5062747501 @default.
- W2912010294 hasAuthorship W2912010294A5064629196 @default.
- W2912010294 hasAuthorship W2912010294A5075674266 @default.
- W2912010294 hasAuthorship W2912010294A5076795537 @default.
- W2912010294 hasAuthorship W2912010294A5085254271 @default.
- W2912010294 hasBestOaLocation W29120102941 @default.
- W2912010294 hasConcept C126322002 @default.
- W2912010294 hasConcept C134018914 @default.
- W2912010294 hasConcept C147789679 @default.
- W2912010294 hasConcept C185592680 @default.
- W2912010294 hasConcept C1862650 @default.
- W2912010294 hasConcept C188816634 @default.
- W2912010294 hasConcept C201903717 @default.
- W2912010294 hasConcept C207103383 @default.
- W2912010294 hasConcept C2776541429 @default.
- W2912010294 hasConcept C2777180221 @default.
- W2912010294 hasConcept C2778885795 @default.
- W2912010294 hasConcept C44249647 @default.
- W2912010294 hasConcept C50382708 @default.