Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912013957> ?p ?o ?g. }
- W2912013957 abstract "Target identification has been considered as a chief parameter in drug discovery as it fully characterizes on-target and off-target effects of drug binding. Cell signaling receptors, structural proteins, and post-translational modifications of histones by histone deacetylases are the most widespread targets that are progressively being explored. The FDA approved histone deacetylases inhibitors and the majority of HDACi in and out of clinical trials based on the activities of 11 isoforms of the enzyme in non-selective influence approach. Unfortunately, reported HDACi does not possess a high degree of structural specificity and ultimately lessens the therapeutic index with many dose limiting toxicities. This chapter illustrates how different approaches are incorporated into the novel inhibitors discovery that are truly isoform-selective and which are specifically involved in targeting only a particular isozyme. Further, it highlights the aspects relating to provide a wider therapeutic index with an improved toxicity profile of lead like epigenetic modulators." @default.
- W2912013957 created "2019-02-21" @default.
- W2912013957 creator A5054091731 @default.
- W2912013957 creator A5075234336 @default.
- W2912013957 creator A5082818322 @default.
- W2912013957 date "2019-01-01" @default.
- W2912013957 modified "2023-09-27" @default.
- W2912013957 title "Target Identification of HDAC8 Isoform for the Treatment of Cancer" @default.
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