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- W2912014562 abstract "Axial patterning during planarian regeneration relies on a transcriptional circuit that confers distinct positional information on the two ends of an amputated fragment. The earliest known elements of this system begin demarcating differences between anterior and posterior wounds by 6 h postamputation. However, it is still unknown what upstream events break the axial symmetry, allowing a mutual repressor system to establish invariant, distinct biochemical states at the anterior and posterior ends. Here, we show that bioelectric signaling at 3 h is crucial for the formation of proper anterior-posterior polarity in planaria. Briefly manipulating the endogenous bioelectric state by depolarizing the injured tissue during the first 3 h of regeneration alters gene expression by 6 h postamputation and leads to a double-headed phenotype upon regeneration despite confirmed washout of ionophores from tissue. These data reveal a primary functional role for resting membrane potential taking place within the first 3 h after injury and kick-starting the downstream pattern of events that elaborate anatomy over the following 10 days. We propose a simple model of molecular-genetic mechanisms to explain how physiological events taking place immediately after injury regulate the spatial distribution of downstream gene expression and anatomy of regenerating planaria." @default.
- W2912014562 created "2019-02-21" @default.
- W2912014562 creator A5003184430 @default.
- W2912014562 creator A5012282467 @default.
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- W2912014562 creator A5039187916 @default.
- W2912014562 creator A5045840183 @default.
- W2912014562 creator A5052189866 @default.
- W2912014562 creator A5061199446 @default.
- W2912014562 date "2019-03-01" @default.
- W2912014562 modified "2023-09-29" @default.
- W2912014562 title "The Role of Early Bioelectric Signals in the Regeneration of Planarian Anterior/Posterior Polarity" @default.
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