FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912014699> ?p ?o ?g. }

• W2912014699 endingPage "926" @default.
• W2912014699 startingPage "916" @default.
• W2912014699 abstract "Notwithstanding remarkable treatment success with anti‐PD‐1 monoclonal antibody, oncogenic mechanism of PD‐L1 regulation in gastric cancer (GC) remains poorly understood. We hypothesized that ARID1A might be related to tumor PD‐L1 expression in GC. We found that tumor PD‐L1 positivity was associated with loss of ARID1A and showed trend toward better survival of patients with various molecular subtypes of GC (experimental set, n = 273). Considering heterogeneous ARID1A expression, we validated this using whole tissue sections (n = 159) and found that loss of ARID1A was correlated with microsatellite instability‐high (MSI‐H), Epstein–Barr virus (EBV), and PD‐L1 positivity. Furthermore, for patients with MSI‐H tumors, the degree of PD‐L1 expression was significantly higher in ARID1A‐deficient tumors. After ARID1A knockdown in GC cell lines, total and membranous PD‐L1 protein, and PD‐L1 mRNA levels were increased based on Western blot, flow cytometry, and qRT‐PCR, respectively. With IFN‐γ treatment, PD‐L1 expression was significantly increased both in ARID1A‐deficient cancer cells and controls, but the increase was not more pronounced in the former. Loss of ARID1A increased PD‐L1 via activating AKT signaling, while LY294002 (PI3K inhibitor) decreased PD‐L1 levels. Furthermore, we found that 3 MSI‐H tumors showing highest expression of PD‐L1 had simultaneous KRAS mutation and loss of ARID1A, suggesting a possible synergistic role boosting PD‐L1. Our results strongly indicate that loss of ARID1A is tightly associated with high PD‐L1 expression in GC. These results would increase our understanding of the oncogenic mechanism of PD‐L1 regulation in GC, and also help to find the optimal candidates for immunotherapy." @default.
• W2912014699 created "2019-02-21" @default.
• W2912014699 creator A5013236696 @default.
• W2912014699 creator A5016540646 @default.
• W2912014699 creator A5042100493 @default.
• W2912014699 creator A5052806512 @default.
• W2912014699 creator A5086210184 @default.
• W2912014699 date "2019-02-08" @default.
• W2912014699 modified "2023-10-03" @default.
• W2912014699 title "Functional loss of ARID1A is tightly associated with high PD‐L1 expression in gastric cancer" @default.
• W2912014699 cites W1934432936 @default.
• W2912014699 cites W1940241680 @default.
• W2912014699 cites W2013090484 @default.
• W2912014699 cites W2033697576 @default.
• W2912014699 cites W2040730809 @default.
• W2912014699 cites W2048639573 @default.
• W2912014699 cites W2085659703 @default.
• W2912014699 cites W2086775982 @default.
• W2912014699 cites W2101653483 @default.
• W2912014699 cites W2126547130 @default.
• W2912014699 cites W2129159987 @default.
• W2912014699 cites W2153370290 @default.
• W2912014699 cites W2158348986 @default.
• W2912014699 cites W2196159484 @default.
• W2912014699 cites W2347070489 @default.
• W2912014699 cites W2463035383 @default.
• W2912014699 cites W2492575571 @default.
• W2912014699 cites W2571508762 @default.
• W2912014699 cites W2582671354 @default.
• W2912014699 cites W2604441970 @default.
• W2912014699 cites W2742446628 @default.
• W2912014699 cites W2742532547 @default.
• W2912014699 cites W2747309147 @default.
• W2912014699 cites W2793364080 @default.
• W2912014699 cites W2800832479 @default.
• W2912014699 cites W2802645166 @default.
• W2912014699 cites W2806614796 @default.
• W2912014699 cites W2809431387 @default.
• W2912014699 cites W2884397450 @default.
• W2912014699 cites W2902511134 @default.
• W2912014699 doi "https://doi.org/10.1002/ijc.32140" @default.
• W2912014699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30664822" @default.
• W2912014699 hasPublicationYear "2019" @default.
• W2912014699 type Work @default.
• W2912014699 sameAs 2912014699 @default.
• W2912014699 citedByCount "59" @default.
• W2912014699 countsByYear W29120146992019 @default.
• W2912014699 countsByYear W29120146992020 @default.
• W2912014699 countsByYear W29120146992021 @default.
• W2912014699 countsByYear W29120146992022 @default.
• W2912014699 countsByYear W29120146992023 @default.
• W2912014699 crossrefType "journal-article" @default.
• W2912014699 hasAuthorship W2912014699A5013236696 @default.
• W2912014699 hasAuthorship W2912014699A5016540646 @default.
• W2912014699 hasAuthorship W2912014699A5042100493 @default.
• W2912014699 hasAuthorship W2912014699A5052806512 @default.
• W2912014699 hasAuthorship W2912014699A5086210184 @default.
• W2912014699 hasBestOaLocation W29120146991 @default.
• W2912014699 hasConcept C104317684 @default.
• W2912014699 hasConcept C121608353 @default.
• W2912014699 hasConcept C153911025 @default.
• W2912014699 hasConcept C173396325 @default.
• W2912014699 hasConcept C180754005 @default.
• W2912014699 hasConcept C190283241 @default.
• W2912014699 hasConcept C2777609662 @default.
• W2912014699 hasConcept C2777701055 @default.
• W2912014699 hasConcept C2779767149 @default.
• W2912014699 hasConcept C2781053074 @default.
• W2912014699 hasConcept C2781273526 @default.
• W2912014699 hasConcept C501734568 @default.
• W2912014699 hasConcept C502942594 @default.
• W2912014699 hasConcept C54355233 @default.
• W2912014699 hasConcept C61320498 @default.
• W2912014699 hasConcept C81885089 @default.
• W2912014699 hasConcept C86554907 @default.
• W2912014699 hasConcept C86803240 @default.
• W2912014699 hasConceptScore W2912014699C104317684 @default.
• W2912014699 hasConceptScore W2912014699C121608353 @default.
• W2912014699 hasConceptScore W2912014699C153911025 @default.
• W2912014699 hasConceptScore W2912014699C173396325 @default.
• W2912014699 hasConceptScore W2912014699C180754005 @default.
• W2912014699 hasConceptScore W2912014699C190283241 @default.
• W2912014699 hasConceptScore W2912014699C2777609662 @default.
• W2912014699 hasConceptScore W2912014699C2777701055 @default.
• W2912014699 hasConceptScore W2912014699C2779767149 @default.
• W2912014699 hasConceptScore W2912014699C2781053074 @default.
• W2912014699 hasConceptScore W2912014699C2781273526 @default.
• W2912014699 hasConceptScore W2912014699C501734568 @default.
• W2912014699 hasConceptScore W2912014699C502942594 @default.
• W2912014699 hasConceptScore W2912014699C54355233 @default.
• W2912014699 hasConceptScore W2912014699C61320498 @default.
• W2912014699 hasConceptScore W2912014699C81885089 @default.
• W2912014699 hasConceptScore W2912014699C86554907 @default.
• W2912014699 hasConceptScore W2912014699C86803240 @default.
• W2912014699 hasIssue "4" @default.
• W2912014699 hasLocation W29120146991 @default.
• W2912014699 hasLocation W29120146992 @default.
• W2912014699 hasOpenAccess W2912014699 @default.

• next