FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912015035> ?p ?o ?g. }

• W2912015035 abstract "Collective cell migration plays a pivotal role in development, wound healing, and metastasis, but little is known about the mechanisms and coordination of cell migration in 3D microenvironments. Here, we demonstrate a 3D wound healing assay by photothermal ablation for investigating collective cell migration in epithelial tissue structures. The nanoparticle-mediated photothermal technique creates local hyperthermia for selective cell ablation and induces collective cell migration of 3D tissue structures. By incorporating dynamic single cell gene expression analysis, live cell actin staining, and particle image velocimetry, we show that the wound healing response consists of 3D vortex motion moving toward the wound followed by the formation of multicellular actin bundles and leader cells with active actin-based protrusions. Inhibition of ROCK signaling disrupts the multicellular actin bundle and enhances the formation of leader cells at the leading edge. Furthermore, single cell gene expression analysis, pharmacological perturbation, and RNA interference reveal that Notch1-Dll4 signaling negatively regulates the formation of multicellular actin bundles and leader cells. Taken together, our study demonstrates a platform for investigating 3D collective cell migration and underscores the essential roles of ROCK and Notch1-Dll4 signaling in regulating 3D epithelial wound healing." @default.
• W2912015035 created "2019-02-21" @default.
• W2912015035 creator A5009033820 @default.
• W2912015035 creator A5011948157 @default.
• W2912015035 creator A5021666829 @default.
• W2912015035 creator A5050164418 @default.
• W2912015035 creator A5077028195 @default.
• W2912015035 date "2019-02-13" @default.
• W2912015035 modified "2023-09-25" @default.
• W2912015035 title "Collective Cell Migration in 3D Epithelial Wound Healing" @default.
• W2912015035 cites W1975472487 @default.
• W2912015035 cites W1980888777 @default.
• W2912015035 cites W1998378147 @default.
• W2912015035 cites W2010805937 @default.
• W2912015035 cites W2012376126 @default.
• W2912015035 cites W2012778906 @default.
• W2912015035 cites W2026446225 @default.
• W2912015035 cites W2041587881 @default.
• W2912015035 cites W2043157211 @default.
• W2912015035 cites W2054874597 @default.
• W2912015035 cites W2062664804 @default.
• W2912015035 cites W2069202441 @default.
• W2912015035 cites W2073006837 @default.
• W2912015035 cites W2076394578 @default.
• W2912015035 cites W2089376707 @default.
• W2912015035 cites W2093035070 @default.
• W2912015035 cites W2094098398 @default.
• W2912015035 cites W2103806219 @default.
• W2912015035 cites W2112270062 @default.
• W2912015035 cites W2127362646 @default.
• W2912015035 cites W2130430747 @default.
• W2912015035 cites W2133943800 @default.
• W2912015035 cites W2145013849 @default.
• W2912015035 cites W2154450820 @default.
• W2912015035 cites W2165291363 @default.
• W2912015035 cites W2262797342 @default.
• W2912015035 cites W2290199777 @default.
• W2912015035 cites W2297776087 @default.
• W2912015035 cites W2324855605 @default.
• W2912015035 cites W2329525671 @default.
• W2912015035 cites W2343169334 @default.
• W2912015035 cites W2509731513 @default.
• W2912015035 cites W2583158457 @default.
• W2912015035 cites W2612650514 @default.
• W2912015035 cites W2769648385 @default.
• W2912015035 cites W2887689841 @default.
• W2912015035 cites W904058290 @default.
• W2912015035 doi "https://doi.org/10.1021/acsnano.8b06305" @default.
• W2912015035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30758172" @default.
• W2912015035 hasPublicationYear "2019" @default.
• W2912015035 type Work @default.
• W2912015035 sameAs 2912015035 @default.
• W2912015035 citedByCount "13" @default.
• W2912015035 countsByYear W29120150352020 @default.
• W2912015035 countsByYear W29120150352021 @default.
• W2912015035 countsByYear W29120150352022 @default.
• W2912015035 countsByYear W29120150352023 @default.
• W2912015035 crossrefType "journal-article" @default.
• W2912015035 hasAuthorship W2912015035A5009033820 @default.
• W2912015035 hasAuthorship W2912015035A5011948157 @default.
• W2912015035 hasAuthorship W2912015035A5021666829 @default.
• W2912015035 hasAuthorship W2912015035A5050164418 @default.
• W2912015035 hasAuthorship W2912015035A5077028195 @default.
• W2912015035 hasConcept C109185818 @default.
• W2912015035 hasConcept C125705527 @default.
• W2912015035 hasConcept C137738243 @default.
• W2912015035 hasConcept C1491633281 @default.
• W2912015035 hasConcept C15526883 @default.
• W2912015035 hasConcept C203014093 @default.
• W2912015035 hasConcept C2780269544 @default.
• W2912015035 hasConcept C54355233 @default.
• W2912015035 hasConcept C74318829 @default.
• W2912015035 hasConcept C86803240 @default.
• W2912015035 hasConcept C95444343 @default.
• W2912015035 hasConceptScore W2912015035C109185818 @default.
• W2912015035 hasConceptScore W2912015035C125705527 @default.
• W2912015035 hasConceptScore W2912015035C137738243 @default.
• W2912015035 hasConceptScore W2912015035C1491633281 @default.
• W2912015035 hasConceptScore W2912015035C15526883 @default.
• W2912015035 hasConceptScore W2912015035C203014093 @default.
• W2912015035 hasConceptScore W2912015035C2780269544 @default.
• W2912015035 hasConceptScore W2912015035C54355233 @default.
• W2912015035 hasConceptScore W2912015035C74318829 @default.
• W2912015035 hasConceptScore W2912015035C86803240 @default.
• W2912015035 hasConceptScore W2912015035C95444343 @default.
• W2912015035 hasFunder F4320337349 @default.
• W2912015035 hasFunder F4320337390 @default.
• W2912015035 hasLocation W29120150351 @default.
• W2912015035 hasLocation W29120150352 @default.
• W2912015035 hasOpenAccess W2912015035 @default.
• W2912015035 hasPrimaryLocation W29120150351 @default.
• W2912015035 hasRelatedWork W172711315 @default.
• W2912015035 hasRelatedWork W2013143984 @default.
• W2912015035 hasRelatedWork W2027654334 @default.
• W2912015035 hasRelatedWork W2046226347 @default.
• W2912015035 hasRelatedWork W2050566209 @default.
• W2912015035 hasRelatedWork W2292845959 @default.
• W2912015035 hasRelatedWork W2775286965 @default.
• W2912015035 hasRelatedWork W2784354738 @default.
• W2912015035 hasRelatedWork W2793641861 @default.

• next