Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912016163> ?p ?o ?g. }
- W2912016163 endingPage "529" @default.
- W2912016163 startingPage "529" @default.
- W2912016163 abstract "Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and the number of CRC patients is increasing progressively. Despite the improvement of the surgical techniques and chemotherapy, we have not completely overcome this disease yet due to the metastases. Therefore, understanding the mechanisms through which metastasis occurs is important for overcoming CRC. Normal host cells in the tumor microenvironment, such as macrophages and fibroblasts, have been reported to promote the growth of CRCs. Although neutrophils were originally considered to have defensive functions against tumor cells, it has been revealed that some populations of neutrophils, called as tumor-associated neutrophils (TANs), have tumor-supportive functions. The plasticity between tumor-suppressive and -supportive neutrophils are regulated by transforming growth factor (TGF)-β and Interferon-β signaling. Some studies have demonstrated that TANs promote the spread of cancer cells to distant organs. TANs contribute to the tumor invasion and angiogenesis through the production of matrix metalloproteinase-9 (MMP9), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) in the primary and metastatic sites. Neutrophils also promotes tumor cell dissemination by capturing circulating tumor cells using neutrophil extracellular traps and promote their migration to distant sites. The neutrophil-to-lymphocyte ratio is a well-defined predictive marker for CRC patients. In this review, we highlight the molecular signaling between TANs and CRC cells and the possibility of TANs as a potential target for cancer therapy." @default.
- W2912016163 created "2019-02-21" @default.
- W2912016163 creator A5003865151 @default.
- W2912016163 creator A5020801534 @default.
- W2912016163 creator A5023720249 @default.
- W2912016163 creator A5037771875 @default.
- W2912016163 creator A5059656401 @default.
- W2912016163 creator A5069964282 @default.
- W2912016163 date "2019-01-27" @default.
- W2912016163 modified "2023-10-15" @default.
- W2912016163 title "The Role of Tumor-Associated Neutrophils in Colorectal Cancer" @default.
- W2912016163 cites W1495945591 @default.
- W2912016163 cites W1520425169 @default.
- W2912016163 cites W1574172480 @default.
- W2912016163 cites W1633784490 @default.
- W2912016163 cites W172889106 @default.
- W2912016163 cites W1773399207 @default.
- W2912016163 cites W1831388254 @default.
- W2912016163 cites W1963562976 @default.
- W2912016163 cites W1965065360 @default.
- W2912016163 cites W1969103696 @default.
- W2912016163 cites W1970190307 @default.
- W2912016163 cites W1973033965 @default.
- W2912016163 cites W1982906652 @default.
- W2912016163 cites W1984162437 @default.
- W2912016163 cites W1986986419 @default.
- W2912016163 cites W1991365889 @default.
- W2912016163 cites W1991562400 @default.
- W2912016163 cites W2002157461 @default.
- W2912016163 cites W2006219739 @default.
- W2912016163 cites W2012664772 @default.
- W2912016163 cites W2012828884 @default.
- W2912016163 cites W2017140048 @default.
- W2912016163 cites W2018860370 @default.
- W2912016163 cites W2023164440 @default.
- W2912016163 cites W2025636084 @default.
- W2912016163 cites W2027282723 @default.
- W2912016163 cites W2032769992 @default.
- W2912016163 cites W2037834137 @default.
- W2912016163 cites W2042355069 @default.
- W2912016163 cites W2051250007 @default.
- W2912016163 cites W2060672294 @default.
- W2912016163 cites W2062265555 @default.
- W2912016163 cites W2064315259 @default.
- W2912016163 cites W2069375519 @default.
- W2912016163 cites W2071507111 @default.
- W2912016163 cites W2080037839 @default.
- W2912016163 cites W2085458222 @default.
- W2912016163 cites W2089782191 @default.
- W2912016163 cites W2091371566 @default.
- W2912016163 cites W2095130131 @default.
- W2912016163 cites W2098629025 @default.
- W2912016163 cites W2098888044 @default.
- W2912016163 cites W2100008201 @default.
- W2912016163 cites W2101037339 @default.
- W2912016163 cites W2103965486 @default.
- W2912016163 cites W2104934425 @default.
- W2912016163 cites W2108929503 @default.
- W2912016163 cites W2109930846 @default.
- W2912016163 cites W2111150268 @default.
- W2912016163 cites W2116407404 @default.
- W2912016163 cites W2123105952 @default.
- W2912016163 cites W2125130403 @default.
- W2912016163 cites W2137969223 @default.
- W2912016163 cites W2138694950 @default.
- W2912016163 cites W2139731402 @default.
- W2912016163 cites W2140995313 @default.
- W2912016163 cites W2141815918 @default.
- W2912016163 cites W2144262617 @default.
- W2912016163 cites W2147489608 @default.
- W2912016163 cites W2148543405 @default.
- W2912016163 cites W2150286564 @default.
- W2912016163 cites W2151686792 @default.
- W2912016163 cites W2152196433 @default.
- W2912016163 cites W2155360682 @default.
- W2912016163 cites W2159913536 @default.
- W2912016163 cites W2163581770 @default.
- W2912016163 cites W2164871149 @default.
- W2912016163 cites W2167556553 @default.
- W2912016163 cites W2169535061 @default.
- W2912016163 cites W2171524684 @default.
- W2912016163 cites W2176303881 @default.
- W2912016163 cites W2186246196 @default.
- W2912016163 cites W2237361742 @default.
- W2912016163 cites W2345126661 @default.
- W2912016163 cites W2411767313 @default.
- W2912016163 cites W2416038770 @default.
- W2912016163 cites W2465158514 @default.
- W2912016163 cites W2471500324 @default.
- W2912016163 cites W2489204389 @default.
- W2912016163 cites W2518568684 @default.
- W2912016163 cites W2518932857 @default.
- W2912016163 cites W2580288809 @default.
- W2912016163 cites W2581055553 @default.
- W2912016163 cites W2586679548 @default.
- W2912016163 cites W2592102847 @default.
- W2912016163 cites W2593371437 @default.
- W2912016163 cites W2601868035 @default.