FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912016369> ?p ?o ?g. }

• W2912016369 endingPage "177" @default.
• W2912016369 startingPage "167" @default.
• W2912016369 abstract "Circadian misalignment between sleep and behavioral/feeding rhythms is thought to lead to various health impairments in shift workers. Therefore, we investigated how shift work leads to genome-wide circadian dysregulation in hospital nurses. Female nurses from the University of Alabama at Birmingham (UAB) Hospital working night shift ( n = 9; 29.6 ± 11.4 y) and day shift ( n = 8; 34.9 ± 9.4 y) participated in a 9-day study measuring locomotor activity and core body temperature (CBT) continuously. Additionally, cortisol and melatonin were assayed and peripheral blood mononuclear cells (PBMCs) were harvested for RNA extraction every 3 h on a day off from work. We saw phase desynchrony of core body temperature, peak cortisol, and dim light melatonin onset in individual night-shift subjects compared with day-shift subjects. This variability was evident even though day- and night-shift nurses had similar sleep timing and scheduled meal times on days off. Surprisingly, the phase and rhythmicity of the expression of the clock gene, PER1, in PBMCs were similar for day-shift and night-shift subjects. Genome-wide microarray analysis of PBMCs from a subset of nurses revealed distinct gene expression patterns between night-shift and day-shift subjects. Enrichment analysis showed that day-shift subjects expressed pathways involved in generic transcription and regulation of signal transduction, whereas night-shift subjects expressed pathways such as RNA polymerase I promoter opening, the matrisome, and endocytosis. In addition, there was large variability in the number of rhythmic transcripts among subjects, regardless of shift type. Interestingly, the amplitude of the CBT rhythm appeared to be more consistent with the number of cycling transcripts for each of the 6 subjects than was melatonin rhythm. In summary, we show that shift-work patterns affect circadian alignment and gene expression in PBMCs." @default.
• W2912016369 created "2019-02-21" @default.
• W2912016369 creator A5001920865 @default.
• W2912016369 creator A5015531017 @default.
• W2912016369 creator A5028562393 @default.
• W2912016369 creator A5035012559 @default.
• W2912016369 creator A5067918792 @default.
• W2912016369 creator A5091151080 @default.
• W2912016369 date "2019-02-04" @default.
• W2912016369 modified "2023-10-16" @default.
• W2912016369 title "Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses" @default.
• W2912016369 cites W121567080 @default.
• W2912016369 cites W1508670761 @default.
• W2912016369 cites W1819749417 @default.
• W2912016369 cites W1969180181 @default.
• W2912016369 cites W1992726958 @default.
• W2912016369 cites W1996930593 @default.
• W2912016369 cites W2010226707 @default.
• W2912016369 cites W2013550926 @default.
• W2912016369 cites W2017895170 @default.
• W2912016369 cites W2023911826 @default.
• W2912016369 cites W2024207880 @default.
• W2912016369 cites W2031750133 @default.
• W2912016369 cites W2045805999 @default.
• W2912016369 cites W2056395995 @default.
• W2912016369 cites W2056795472 @default.
• W2912016369 cites W2075565109 @default.
• W2912016369 cites W2082681220 @default.
• W2912016369 cites W2086380623 @default.
• W2912016369 cites W2091912666 @default.
• W2912016369 cites W2095034757 @default.
• W2912016369 cites W2095556201 @default.
• W2912016369 cites W2106608030 @default.
• W2912016369 cites W2117375244 @default.
• W2912016369 cites W2119930244 @default.
• W2912016369 cites W2122143410 @default.
• W2912016369 cites W2128492385 @default.
• W2912016369 cites W2139672495 @default.
• W2912016369 cites W2145684092 @default.
• W2912016369 cites W2156263298 @default.
• W2912016369 cites W2162691926 @default.
• W2912016369 cites W2164578725 @default.
• W2912016369 cites W2299324591 @default.
• W2912016369 cites W2332542558 @default.
• W2912016369 cites W236641151 @default.
• W2912016369 cites W2463616135 @default.
• W2912016369 cites W2591942067 @default.
• W2912016369 cites W2802571577 @default.
• W2912016369 cites W2803363391 @default.
• W2912016369 doi "https://doi.org/10.1177/0748730419826694" @default.
• W2912016369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542471" @default.
• W2912016369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712475" @default.
• W2912016369 hasPublicationYear "2019" @default.
• W2912016369 type Work @default.
• W2912016369 sameAs 2912016369 @default.
• W2912016369 citedByCount "34" @default.
• W2912016369 countsByYear W29120163692019 @default.
• W2912016369 countsByYear W29120163692020 @default.
• W2912016369 countsByYear W29120163692021 @default.
• W2912016369 countsByYear W29120163692022 @default.
• W2912016369 countsByYear W29120163692023 @default.
• W2912016369 crossrefType "journal-article" @default.
• W2912016369 hasAuthorship W2912016369A5001920865 @default.
• W2912016369 hasAuthorship W2912016369A5015531017 @default.
• W2912016369 hasAuthorship W2912016369A5028562393 @default.
• W2912016369 hasAuthorship W2912016369A5035012559 @default.
• W2912016369 hasAuthorship W2912016369A5067918792 @default.
• W2912016369 hasAuthorship W2912016369A5091151080 @default.
• W2912016369 hasBestOaLocation W29120163692 @default.
• W2912016369 hasConcept C104317684 @default.
• W2912016369 hasConcept C121446783 @default.
• W2912016369 hasConcept C126322002 @default.
• W2912016369 hasConcept C134018914 @default.
• W2912016369 hasConcept C150194340 @default.
• W2912016369 hasConcept C162317418 @default.
• W2912016369 hasConcept C169760540 @default.
• W2912016369 hasConcept C184738001 @default.
• W2912016369 hasConcept C186836561 @default.
• W2912016369 hasConcept C2776176791 @default.
• W2912016369 hasConcept C2778182776 @default.
• W2912016369 hasConcept C38606739 @default.
• W2912016369 hasConcept C54355233 @default.
• W2912016369 hasConcept C71924100 @default.
• W2912016369 hasConcept C86803240 @default.
• W2912016369 hasConceptScore W2912016369C104317684 @default.
• W2912016369 hasConceptScore W2912016369C121446783 @default.
• W2912016369 hasConceptScore W2912016369C126322002 @default.
• W2912016369 hasConceptScore W2912016369C134018914 @default.
• W2912016369 hasConceptScore W2912016369C150194340 @default.
• W2912016369 hasConceptScore W2912016369C162317418 @default.
• W2912016369 hasConceptScore W2912016369C169760540 @default.
• W2912016369 hasConceptScore W2912016369C184738001 @default.
• W2912016369 hasConceptScore W2912016369C186836561 @default.
• W2912016369 hasConceptScore W2912016369C2776176791 @default.
• W2912016369 hasConceptScore W2912016369C2778182776 @default.
• W2912016369 hasConceptScore W2912016369C38606739 @default.
• W2912016369 hasConceptScore W2912016369C54355233 @default.
• W2912016369 hasConceptScore W2912016369C71924100 @default.

• next