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• W2912016787 abstract "Potato virus X (PVX) is a flexuous plant virus-based nanotechnology with promise in cancer therapy. As a high aspect ratio biologic (13 × 515 nm), PVX has excellent spatial control in structures and functions, offering high-precision nanoengineering for multivalent display of functional moieties. Herein, we demonstrate the preparation of the PVX-based nanocarrier for delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a promising protein drug that induces apoptosis in cancer cells but not healthy cells. TRAIL bound to PVX by coordination bonds between nickel-coordinated nitrilotriacetic acid on PVX and His-tag on the protein could mimic the bioactive “membrane-bound” state in native TRAIL, resulting in an elongated nanoparticle displaying up 490 therapeutic protein molecules. Our data show that PVX-delivered TRAIL activates caspase-mediated apoptosis more efficiently compared to soluble TRAIL; also in vivo the therapeutic nanoparticle outperforms in delaying tumor growth in an athymic nude mouse model bearing human triple-negative breast cancer xenografts. This proof-of-concept work highlights the potential of filamentous plant virus nanotechnologies, particularly for targeting protein drug delivery for cancer therapy." @default.
• W2912016787 created "2019-02-21" @default.
• W2912016787 creator A5019412759 @default.
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• W2912016787 date "2019-01-22" @default.
• W2912016787 modified "2023-10-17" @default.
• W2912016787 title "Presentation and Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand <i>via</i> Elongated Plant Viral Nanoparticle Enhances Antitumor Efficacy" @default.
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• W2912016787 doi "https://doi.org/10.1021/acsnano.8b09462" @default.
• W2912016787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30668110" @default.
• W2912016787 hasPublicationYear "2019" @default.
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