FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912017209> ?p ?o ?g. }

• W2912017209 endingPage "70" @default.
• W2912017209 startingPage "55" @default.
• W2912017209 abstract "We investigated if transcriptional responses are consistent with the arrest of synaptic activity in the anoxic turtle (Trachemys scripta) brain. Thirty-nine genes of key receptors, transporters, enzymes and regulatory proteins of inhibitory and excitatory neurotransmission were partially cloned and their expression in telencephalon of 21 °C- and 5 °C-acclimated normoxic, anoxic (24 h at 21 °C; 1 and 14 days at 5 °C) and reoxygenated (24 h at 21 °C; 13 days at 5 °C) turtles quantified by real-time RT-PCR. Gene expression was largely sustained with anoxia at 21 °C and 5 °C. However, the changes in gene expression that did occur were congruous with the decline in glutamatergic activity and the increase in GABAergic activity observed at cellular and whole organism levels. Moreover, at 21 °C, the alterations in gene expression with anoxia induced a distinct gene expression pattern compared to normoxia and reoxygenation. Strikingly, acclimation from 21 °C to 5 °C in normoxia effectuated substantial transcriptional responses. Most prominently, 56% of the excitatory neurotransmission genes were down-regulated, including most of the ones encoding the subunits composing excitatory N-methyl-d-aspartate (NMDA) and 3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptors. By contrast, only 26% of the inhibitory neurotransmission genes were down-regulated. Consequently, the gene expression pattern of 5 °C normoxic turtles was statistically distinct compared to that of 21 °C normoxic turtles. Overall, this study highlights that key transcriptional responses are consonant with the synaptic arrest that occurs in the anoxic turtle brain. In addition, the findings reveal that transcriptional remodelling induced by decreased temperature may serve to precondition the turtle brain for winter anoxia." @default.
• W2912017209 created "2019-02-21" @default.
• W2912017209 creator A5002228028 @default.
• W2912017209 creator A5018279192 @default.
• W2912017209 creator A5038419476 @default.
• W2912017209 creator A5049152477 @default.
• W2912017209 creator A5063838243 @default.
• W2912017209 creator A5068836528 @default.
• W2912017209 creator A5070734296 @default.
• W2912017209 date "2019-06-01" @default.
• W2912017209 modified "2023-09-23" @default.
• W2912017209 title "The expression of genes involved in excitatory and inhibitory neurotransmission in turtle (Trachemys scripta) brain during anoxic submergence at 21 °C and 5 °C reveals the importance of cold as a preparatory cue for anoxia survival" @default.
• W2912017209 cites W1487317148 @default.
• W2912017209 cites W1573412658 @default.
• W2912017209 cites W1584606142 @default.
• W2912017209 cites W1935545948 @default.
• W2912017209 cites W1964127562 @default.
• W2912017209 cites W1964660650 @default.
• W2912017209 cites W1965970232 @default.
• W2912017209 cites W1970724978 @default.
• W2912017209 cites W1971043748 @default.
• W2912017209 cites W1977092358 @default.
• W2912017209 cites W1980710619 @default.
• W2912017209 cites W1984116072 @default.
• W2912017209 cites W1985090470 @default.
• W2912017209 cites W1987306200 @default.
• W2912017209 cites W1997862361 @default.
• W2912017209 cites W1998217227 @default.
• W2912017209 cites W1998542194 @default.
• W2912017209 cites W2004784342 @default.
• W2912017209 cites W2009771084 @default.
• W2912017209 cites W2012356998 @default.
• W2912017209 cites W2015851788 @default.
• W2912017209 cites W2017349018 @default.
• W2912017209 cites W2023638511 @default.
• W2912017209 cites W2025256394 @default.
• W2912017209 cites W2036873456 @default.
• W2912017209 cites W2041316588 @default.
• W2912017209 cites W2041842787 @default.
• W2912017209 cites W2044604492 @default.
• W2912017209 cites W2047243202 @default.
• W2912017209 cites W2047283392 @default.
• W2912017209 cites W2050066016 @default.
• W2912017209 cites W2051084778 @default.
• W2912017209 cites W2058571616 @default.
• W2912017209 cites W2058825628 @default.
• W2912017209 cites W2065380916 @default.
• W2912017209 cites W2070931581 @default.
• W2912017209 cites W2072930187 @default.
• W2912017209 cites W2074385487 @default.
• W2912017209 cites W2074940885 @default.
• W2912017209 cites W2079636726 @default.
• W2912017209 cites W2082180868 @default.
• W2912017209 cites W2086126018 @default.
• W2912017209 cites W2088607178 @default.
• W2912017209 cites W2091208643 @default.
• W2912017209 cites W2097382368 @default.
• W2912017209 cites W2099604895 @default.
• W2912017209 cites W2101604882 @default.
• W2912017209 cites W2102973376 @default.
• W2912017209 cites W2105084936 @default.
• W2912017209 cites W2108909652 @default.
• W2912017209 cites W2124579236 @default.
• W2912017209 cites W2125202608 @default.
• W2912017209 cites W2126449361 @default.
• W2912017209 cites W2128338256 @default.
• W2912017209 cites W2130656511 @default.
• W2912017209 cites W2131300789 @default.
• W2912017209 cites W2131360646 @default.
• W2912017209 cites W2135608921 @default.
• W2912017209 cites W2136309995 @default.
• W2912017209 cites W2137689860 @default.
• W2912017209 cites W2144291596 @default.
• W2912017209 cites W2147542138 @default.
• W2912017209 cites W2148367096 @default.
• W2912017209 cites W2152993255 @default.
• W2912017209 cites W2160644313 @default.
• W2912017209 cites W2164924640 @default.
• W2912017209 cites W2169810802 @default.
• W2912017209 cites W2170329919 @default.
• W2912017209 cites W2231682594 @default.
• W2912017209 cites W2278469987 @default.
• W2912017209 cites W2303637751 @default.
• W2912017209 cites W2349918789 @default.
• W2912017209 cites W2494833949 @default.
• W2912017209 cites W2552390210 @default.
• W2912017209 cites W2576205893 @default.
• W2912017209 cites W2763242480 @default.
• W2912017209 cites W2768430562 @default.
• W2912017209 cites W2775395677 @default.
• W2912017209 cites W2790280998 @default.
• W2912017209 cites W292775738 @default.
• W2912017209 doi "https://doi.org/10.1016/j.cbd.2018.12.010" @default.
• W2912017209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30780100" @default.
• W2912017209 hasPublicationYear "2019" @default.
• W2912017209 type Work @default.
• W2912017209 sameAs 2912017209 @default.
• W2912017209 citedByCount "11" @default.

• next