Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912018574> ?p ?o ?g. }
- W2912018574 abstract "Viruses usurp cellular factors to invade host cells. Activation and utilization of these proteins upon initiation of viral infection are therefore required for productive infection and resultant viral disease. The majority of healthy individuals are asymptomatically infected by JC polyomavirus (JCPyV), but if the host immune system is compromised, JCPyV can cause progressive multifocal leukoencephalopathy (PML), a rare, fatal, demyelinating disease. Individuals infected with HIV or taking prolonged immunomodulatory therapies have a heightened risk for developing PML. The cellular proteins and pathways utilized by JCPyV to mediate viral entry are poorly understood. Our findings further characterize how JCPyV utilizes the clathrin-mediated endocytosis pathway to invade host cells. We have identified specific components of this pathway that are necessary for the viral entry process and infection. Collectively, the conclusions increase our understanding of JCPyV infection and pathogenesis and may contribute to the future development of novel therapeutic strategies for PML." @default.
- W2912018574 created "2019-02-21" @default.
- W2912018574 creator A5020587711 @default.
- W2912018574 creator A5043355585 @default.
- W2912018574 creator A5059463791 @default.
- W2912018574 creator A5076826339 @default.
- W2912018574 creator A5091733831 @default.
- W2912018574 date "2019-04-15" @default.
- W2912018574 modified "2023-10-14" @default.
- W2912018574 title "JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin" @default.
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