FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912019527> ?p ?o ?g. }

• W2912019527 endingPage "566" @default.
• W2912019527 startingPage "557" @default.
• W2912019527 abstract "MicroRNA plays a vital role in the regulation of host-parasite interaction. In recent years, genomic and transcriptomic resources have become increasingly available for many helminths, but only a limited number of reports in this area are on the regulatory effects of host microRNAs on parasitic nematodes. In this work, we screened increased expression of host microRNAs after nematode infection from miRNA-seq data and predicted target genes by combined bioinformatics analysis and transcriptional profiling. We elucidated regulatory effects of one host miRNA on nematode infection using miRNA inhibitor and adeno-associated virus (AAV)-based TuD miRNA inhibitor. Using AAV-based TuD miRNA inhibitor, we showed that stable blockade of mmu-miR-101b-3p could alleviate the pathological damages of Angiostrongylus cantonensis, a parasitic nematode. Data from a luciferase report assay showed that mmu-miR-101b-3p targeted the extracellular superoxide dismutase 3 (Acsod3). Increased Acsod3 expression in larvae and alleviated oxidative damages were seen in the groups receiving mmu-miR-101b-3p inhibitor treatment in vitro and AAV-based TuD miRNA inhibitor injection in vivo. Results of this study demonstrate that murine miR-101b-3p inhibits the expression of antioxidant enzyme in A. cantonensis to strengthen host oxidative responses to nematodes. This work expands our knowledge of interspecies regulation of nematode gene expression by of host miRNAs." @default.
• W2912019527 created "2019-02-21" @default.
• W2912019527 creator A5040915323 @default.
• W2912019527 creator A5053604368 @default.
• W2912019527 creator A5056369021 @default.
• W2912019527 creator A5059055670 @default.
• W2912019527 creator A5067288032 @default.
• W2912019527 date "2019-05-01" @default.
• W2912019527 modified "2023-09-24" @default.
• W2912019527 title "Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3" @default.
• W2912019527 cites W1572269621 @default.
• W2912019527 cites W1963526005 @default.
• W2912019527 cites W1965276015 @default.
• W2912019527 cites W1965825218 @default.
• W2912019527 cites W1970382733 @default.
• W2912019527 cites W1981415201 @default.
• W2912019527 cites W1988388755 @default.
• W2912019527 cites W1988693311 @default.
• W2912019527 cites W1996131102 @default.
• W2912019527 cites W2004120115 @default.
• W2912019527 cites W2019496525 @default.
• W2912019527 cites W2035113359 @default.
• W2912019527 cites W2037965198 @default.
• W2912019527 cites W2040191060 @default.
• W2912019527 cites W2041347477 @default.
• W2912019527 cites W2054349381 @default.
• W2912019527 cites W2057587536 @default.
• W2912019527 cites W2060678687 @default.
• W2912019527 cites W2068485375 @default.
• W2912019527 cites W2072115966 @default.
• W2912019527 cites W2086567516 @default.
• W2912019527 cites W2104316181 @default.
• W2912019527 cites W2117474869 @default.
• W2912019527 cites W2119885610 @default.
• W2912019527 cites W2128520557 @default.
• W2912019527 cites W2134629862 @default.
• W2912019527 cites W2144008452 @default.
• W2912019527 cites W2149748804 @default.
• W2912019527 cites W2168230240 @default.
• W2912019527 cites W2300631879 @default.
• W2912019527 cites W2414624742 @default.
• W2912019527 cites W2551137278 @default.
• W2912019527 cites W2560740462 @default.
• W2912019527 cites W2626922440 @default.
• W2912019527 cites W2735231127 @default.
• W2912019527 cites W2746808011 @default.
• W2912019527 cites W4211019730 @default.
• W2912019527 doi "https://doi.org/10.1016/j.bbagrm.2019.02.004" @default.
• W2912019527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30763737" @default.
• W2912019527 hasPublicationYear "2019" @default.
• W2912019527 type Work @default.
• W2912019527 sameAs 2912019527 @default.
• W2912019527 citedByCount "5" @default.
• W2912019527 countsByYear W29120195272020 @default.
• W2912019527 countsByYear W29120195272021 @default.
• W2912019527 countsByYear W29120195272023 @default.
• W2912019527 crossrefType "journal-article" @default.
• W2912019527 hasAuthorship W2912019527A5040915323 @default.
• W2912019527 hasAuthorship W2912019527A5053604368 @default.
• W2912019527 hasAuthorship W2912019527A5056369021 @default.
• W2912019527 hasAuthorship W2912019527A5059055670 @default.
• W2912019527 hasAuthorship W2912019527A5067288032 @default.
• W2912019527 hasConcept C104317684 @default.
• W2912019527 hasConcept C145059251 @default.
• W2912019527 hasConcept C150194340 @default.
• W2912019527 hasConcept C162317418 @default.
• W2912019527 hasConcept C165901193 @default.
• W2912019527 hasConcept C18431079 @default.
• W2912019527 hasConcept C18903297 @default.
• W2912019527 hasConcept C203014093 @default.
• W2912019527 hasConcept C2775838275 @default.
• W2912019527 hasConcept C2776151105 @default.
• W2912019527 hasConcept C2776349312 @default.
• W2912019527 hasConcept C2778830712 @default.
• W2912019527 hasConcept C2781269127 @default.
• W2912019527 hasConcept C54355233 @default.
• W2912019527 hasConcept C55493867 @default.
• W2912019527 hasConcept C86803240 @default.
• W2912019527 hasConceptScore W2912019527C104317684 @default.
• W2912019527 hasConceptScore W2912019527C145059251 @default.
• W2912019527 hasConceptScore W2912019527C150194340 @default.
• W2912019527 hasConceptScore W2912019527C162317418 @default.
• W2912019527 hasConceptScore W2912019527C165901193 @default.
• W2912019527 hasConceptScore W2912019527C18431079 @default.
• W2912019527 hasConceptScore W2912019527C18903297 @default.
• W2912019527 hasConceptScore W2912019527C203014093 @default.
• W2912019527 hasConceptScore W2912019527C2775838275 @default.
• W2912019527 hasConceptScore W2912019527C2776151105 @default.
• W2912019527 hasConceptScore W2912019527C2776349312 @default.
• W2912019527 hasConceptScore W2912019527C2778830712 @default.
• W2912019527 hasConceptScore W2912019527C2781269127 @default.
• W2912019527 hasConceptScore W2912019527C54355233 @default.
• W2912019527 hasConceptScore W2912019527C55493867 @default.
• W2912019527 hasConceptScore W2912019527C86803240 @default.
• W2912019527 hasFunder F4320327912 @default.
• W2912019527 hasIssue "5" @default.
• W2912019527 hasLocation W29120195271 @default.
• W2912019527 hasLocation W29120195272 @default.

• next