FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912019888> ?p ?o ?g. }

• W2912019888 endingPage "813" @default.
• W2912019888 startingPage "802" @default.
• W2912019888 abstract "Background Metronidazole is the preferred empirical anti‐anaerobic agent for patients with suspected anaerobic infection. The balance between benefits and harms of empirical metronidazole is unclear. We aimed to assess patient‐important benefits and harms of empirical metronidazole vs placebo/no treatment in adult patients with severe bacterial infection of any origin. Methods We conducted a systematic review with meta‐analysis and trial sequential analysis of randomized clinical trials assessing empirical metronidazole vs placebo/no treatment in adult hospitalized patients with severe bacterial infection. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) statement, the Cochrane Handbook and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. A protocol and statistical analysis plan was published prior to conducting the review. Results We included a total of nine trials (n = 1753 patients), all of which were adjudicated as having high risk of bias. We found no difference in the primary outcome mortality within 90 days (relative risk 1.56, 95% confidence interval 0.39‐6.25). Fewer patients receiving metronidazole had secondary infections (relative risk 0.43, 95% CI: 0.27‐0.68). Trial sequential analysis indicated high risk of random errors due to lack of data, and the quality of evidence was very low for all outcomes. Conclusions There is low quantity and quality of evidence supporting the use of empirical metronidazole in adult patients with severe bacterial infections of any origin, and no firm evidence for benefit or harm." @default.
• W2912019888 created "2019-02-21" @default.
• W2912019888 creator A5010007004 @default.
• W2912019888 creator A5013991674 @default.
• W2912019888 creator A5020727172 @default.
• W2912019888 creator A5045762489 @default.
• W2912019888 creator A5052237362 @default.
• W2912019888 creator A5091047466 @default.
• W2912019888 date "2019-02-06" @default.
• W2912019888 modified "2023-10-16" @default.
• W2912019888 title "Empirical metronidazole for patients with severe bacterial infection: A systematic review with meta‐analysis and trial sequential analysis" @default.
• W2912019888 cites W124567617 @default.
• W2912019888 cites W1247968195 @default.
• W2912019888 cites W1854399771 @default.
• W2912019888 cites W1964502734 @default.
• W2912019888 cites W1964832813 @default.
• W2912019888 cites W1969682850 @default.
• W2912019888 cites W1971441597 @default.
• W2912019888 cites W1979366262 @default.
• W2912019888 cites W1992819640 @default.
• W2912019888 cites W2007072192 @default.
• W2912019888 cites W2007872832 @default.
• W2912019888 cites W2021046234 @default.
• W2912019888 cites W2021096829 @default.
• W2912019888 cites W2039338555 @default.
• W2912019888 cites W2039565098 @default.
• W2912019888 cites W2055469806 @default.
• W2912019888 cites W2057791349 @default.
• W2912019888 cites W2071291245 @default.
• W2912019888 cites W2084974781 @default.
• W2912019888 cites W2086507424 @default.
• W2912019888 cites W2089776578 @default.
• W2912019888 cites W2108107972 @default.
• W2912019888 cites W2112972569 @default.
• W2912019888 cites W2117397026 @default.
• W2912019888 cites W2119605658 @default.
• W2912019888 cites W2123378243 @default.
• W2912019888 cites W2126806813 @default.
• W2912019888 cites W2126930838 @default.
• W2912019888 cites W2126935647 @default.
• W2912019888 cites W2139808382 @default.
• W2912019888 cites W2149186506 @default.
• W2912019888 cites W2149210474 @default.
• W2912019888 cites W2153021661 @default.
• W2912019888 cites W2170952317 @default.
• W2912019888 cites W2177723577 @default.
• W2912019888 cites W2329850597 @default.
• W2912019888 cites W2464928227 @default.
• W2912019888 cites W2583549666 @default.
• W2912019888 cites W2694691677 @default.
• W2912019888 cites W2767489815 @default.
• W2912019888 cites W2792809609 @default.
• W2912019888 cites W2809502133 @default.
• W2912019888 cites W3024247247 @default.
• W2912019888 doi "https://doi.org/10.1111/aas.13327" @default.
• W2912019888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30729495" @default.
• W2912019888 hasPublicationYear "2019" @default.
• W2912019888 type Work @default.
• W2912019888 sameAs 2912019888 @default.
• W2912019888 citedByCount "0" @default.
• W2912019888 crossrefType "journal-article" @default.
• W2912019888 hasAuthorship W2912019888A5010007004 @default.
• W2912019888 hasAuthorship W2912019888A5013991674 @default.
• W2912019888 hasAuthorship W2912019888A5020727172 @default.
• W2912019888 hasAuthorship W2912019888A5045762489 @default.
• W2912019888 hasAuthorship W2912019888A5052237362 @default.
• W2912019888 hasAuthorship W2912019888A5091047466 @default.
• W2912019888 hasConcept C126322002 @default.
• W2912019888 hasConcept C142724271 @default.
• W2912019888 hasConcept C168563851 @default.
• W2912019888 hasConcept C17744445 @default.
• W2912019888 hasConcept C177713679 @default.
• W2912019888 hasConcept C189708586 @default.
• W2912019888 hasConcept C199539241 @default.
• W2912019888 hasConcept C204787440 @default.
• W2912019888 hasConcept C27081682 @default.
• W2912019888 hasConcept C2777396551 @default.
• W2912019888 hasConcept C2779473830 @default.
• W2912019888 hasConcept C44249647 @default.
• W2912019888 hasConcept C501593827 @default.
• W2912019888 hasConcept C71924100 @default.
• W2912019888 hasConcept C82789193 @default.
• W2912019888 hasConcept C86803240 @default.
• W2912019888 hasConcept C89423630 @default.
• W2912019888 hasConcept C95190672 @default.
• W2912019888 hasConceptScore W2912019888C126322002 @default.
• W2912019888 hasConceptScore W2912019888C142724271 @default.
• W2912019888 hasConceptScore W2912019888C168563851 @default.
• W2912019888 hasConceptScore W2912019888C17744445 @default.
• W2912019888 hasConceptScore W2912019888C177713679 @default.
• W2912019888 hasConceptScore W2912019888C189708586 @default.
• W2912019888 hasConceptScore W2912019888C199539241 @default.
• W2912019888 hasConceptScore W2912019888C204787440 @default.
• W2912019888 hasConceptScore W2912019888C27081682 @default.
• W2912019888 hasConceptScore W2912019888C2777396551 @default.
• W2912019888 hasConceptScore W2912019888C2779473830 @default.
• W2912019888 hasConceptScore W2912019888C44249647 @default.
• W2912019888 hasConceptScore W2912019888C501593827 @default.

• next