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• W2912022567 abstract "Clostridium thermocellum is a good candidate organism for producing cellulosic biofuels due to its native ability to ferment cellulose, however its maximum biofuel titer is limited by tolerance. Wild type C. thermocellum is inhibited by 5 g/L n-butanol. Using growth adaptation in a chemostat, we increased n-butanol tolerance to 15 g/L. We discovered that several tolerant strains had acquired a D494G mutation in the adhE gene. Re-introducing this mutation recapitulated the n-butanol tolerance phenotype. In addition, it increased tolerance to several other primary alcohols including isobutanol and ethanol. To confirm that adhE is the cause of inhibition by primary alcohols, we showed that deleting adhE also increases tolerance to several primary alcohols." @default.
• W2912022567 created "2019-02-21" @default.
• W2912022567 creator A5009999197 @default.
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• W2912022567 date "2019-02-11" @default.
• W2912022567 modified "2023-09-30" @default.
• W2912022567 title "A mutation in the AdhE alcohol dehydrogenase of Clostridium thermocellum increases tolerance to several primary alcohols, including isobutanol, n-butanol and ethanol" @default.
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• W2912022567 doi "https://doi.org/10.1038/s41598-018-37979-5" @default.
• W2912022567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6370804" @default.
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• W2912022567 hasPublicationYear "2019" @default.
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