FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912031299> ?p ?o ?g. }

• W2912031299 endingPage "698" @default.
• W2912031299 startingPage "690" @default.
• W2912031299 abstract "Background: As a potent pro-inflammatory cytokine of the interleukin (IL)-1 family, IL-18 was elevated in early active and progressive plaque-type psoriatic lesions and that serum or plasma levels of IL-18 correlated with the Psoriasis Area and Severity Index (PASI). Although results from previous studies have established that IL-18 may aggravate psoriatic inflammation, the mechanisms of this process remain unknown. In this study, IL-18 knock out (KO) mice and wild-type (WT) mice were used to investigate the effects of IL-18 within a mouse model of psoriasis. Methods: WT and IL-18 KO mice were divided into four groups, including imiquimod (IMQ)-treated IL-18 KO group (n = 11) and WT group (n = 13) as well as their respectively gene-matched control mice (receiving vaseline; n = 12). PASI scores were used to evaluate psoriatic lesions in IMQ-treated mice. Pathological features and dermal cellular infiltration were investigated by hematoxylin and eosin staining. The levels of psoriasis-related cytokines including IL-23, IL-17, IL-12, IL-1β, IFNγ, IL-15, IL-27, and IL-4 were tested by real-time polymerase chain reaction (PCR). The protein level of IL-1β, IL-27, CXCL1, and Ly6 g were investigated by immunohistochemistry (IHC). Results: Acanthosis (98.46 ± 14.12 vs. 222.68 ± 71.10 μm, P < 0.01) and dermal cell infiltration (572.25 ± 47.45 vs. 762.47 ± 59.59 cells/field, P < 0.01) were significantly milder in IMQ-induced IL-18 KO mice compared with that in WT mice. IMQ-induced IL-18 KO mice manifested larger areas of Munro microabscesses (11,467.83 ± 5112.09 vs. 4093.19 ± 2591.88 μm2, P < 0.01) and scales (100,935.24 ± 41,167.77 vs. 41,604.41 ± 14,184.10 μm2, P < 0.01) as compared with WT mice. In skin lesions of IL-18 KO mice, the expressions of IL-1β, IL-4, and IL-27 were all significantly upregulated but IL-17 was decreased. Histologically, strong positive signals of Ly6g were observed within the epidermis of IL-18 KO mice but expressions of CXCL1 were decreased. Conclusions: IL-18 may exacerbate prominent inflammation and influence pathological features in IMQ-induced mouse model of psoriasis. IL-18 may upregulate pro-inflammatory cytokines and reduce protective cytokines, thus aggravating psoriatic inflammation. In addition, IL-18 may be involved in the formation of Munro microabscesses and scales." @default.
• W2912031299 created "2019-02-21" @default.
• W2912031299 creator A5013861025 @default.
• W2912031299 creator A5039214243 @default.
• W2912031299 creator A5059942460 @default.
• W2912031299 creator A5072516184 @default.
• W2912031299 creator A5073530273 @default.
• W2912031299 creator A5080744549 @default.
• W2912031299 creator A5083886586 @default.
• W2912031299 creator A5088082429 @default.
• W2912031299 date "2019-03-20" @default.
• W2912031299 modified "2023-10-13" @default.
• W2912031299 title "Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis" @default.
• W2912031299 cites W1483095827 @default.
• W2912031299 cites W1580232799 @default.
• W2912031299 cites W1664996601 @default.
• W2912031299 cites W1775413382 @default.
• W2912031299 cites W1928621728 @default.
• W2912031299 cites W1939997832 @default.
• W2912031299 cites W1970678723 @default.
• W2912031299 cites W1978716008 @default.
• W2912031299 cites W1981177225 @default.
• W2912031299 cites W1991658642 @default.
• W2912031299 cites W2005242977 @default.
• W2912031299 cites W2009312314 @default.
• W2912031299 cites W2027812158 @default.
• W2912031299 cites W2042514128 @default.
• W2912031299 cites W2048836154 @default.
• W2912031299 cites W2058672282 @default.
• W2912031299 cites W2062838126 @default.
• W2912031299 cites W2064856766 @default.
• W2912031299 cites W2065025049 @default.
• W2912031299 cites W2066442488 @default.
• W2912031299 cites W2085926863 @default.
• W2912031299 cites W2089274189 @default.
• W2912031299 cites W2123946257 @default.
• W2912031299 cites W2135834476 @default.
• W2912031299 cites W2138811709 @default.
• W2912031299 cites W2159513688 @default.
• W2912031299 cites W2195167637 @default.
• W2912031299 cites W2221664966 @default.
• W2912031299 cites W2399274691 @default.
• W2912031299 cites W2607051422 @default.
• W2912031299 cites W2789417546 @default.
• W2912031299 cites W4211077900 @default.
• W2912031299 doi "https://doi.org/10.1097/cm9.0000000000000140" @default.
• W2912031299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416030" @default.
• W2912031299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30741833" @default.
• W2912031299 hasPublicationYear "2019" @default.
• W2912031299 type Work @default.
• W2912031299 sameAs 2912031299 @default.
• W2912031299 citedByCount "18" @default.
• W2912031299 countsByYear W29120312992020 @default.
• W2912031299 countsByYear W29120312992021 @default.
• W2912031299 countsByYear W29120312992022 @default.
• W2912031299 countsByYear W29120312992023 @default.
• W2912031299 crossrefType "journal-article" @default.
• W2912031299 hasAuthorship W2912031299A5013861025 @default.
• W2912031299 hasAuthorship W2912031299A5039214243 @default.
• W2912031299 hasAuthorship W2912031299A5059942460 @default.
• W2912031299 hasAuthorship W2912031299A5072516184 @default.
• W2912031299 hasAuthorship W2912031299A5073530273 @default.
• W2912031299 hasAuthorship W2912031299A5080744549 @default.
• W2912031299 hasAuthorship W2912031299A5083886586 @default.
• W2912031299 hasAuthorship W2912031299A5088082429 @default.
• W2912031299 hasBestOaLocation W29120312991 @default.
• W2912031299 hasConcept C125473707 @default.
• W2912031299 hasConcept C13373296 @default.
• W2912031299 hasConcept C142724271 @default.
• W2912031299 hasConcept C203014093 @default.
• W2912031299 hasConcept C204232928 @default.
• W2912031299 hasConcept C2776914184 @default.
• W2912031299 hasConcept C2777011040 @default.
• W2912031299 hasConcept C2778478263 @default.
• W2912031299 hasConcept C2778690821 @default.
• W2912031299 hasConcept C2779112978 @default.
• W2912031299 hasConcept C2779915019 @default.
• W2912031299 hasConcept C2780269544 @default.
• W2912031299 hasConcept C2780564577 @default.
• W2912031299 hasConcept C31849713 @default.
• W2912031299 hasConcept C47348012 @default.
• W2912031299 hasConcept C71924100 @default.
• W2912031299 hasConcept C74172505 @default.
• W2912031299 hasConcept C96525457 @default.
• W2912031299 hasConceptScore W2912031299C125473707 @default.
• W2912031299 hasConceptScore W2912031299C13373296 @default.
• W2912031299 hasConceptScore W2912031299C142724271 @default.
• W2912031299 hasConceptScore W2912031299C203014093 @default.
• W2912031299 hasConceptScore W2912031299C204232928 @default.
• W2912031299 hasConceptScore W2912031299C2776914184 @default.
• W2912031299 hasConceptScore W2912031299C2777011040 @default.
• W2912031299 hasConceptScore W2912031299C2778478263 @default.
• W2912031299 hasConceptScore W2912031299C2778690821 @default.
• W2912031299 hasConceptScore W2912031299C2779112978 @default.
• W2912031299 hasConceptScore W2912031299C2779915019 @default.
• W2912031299 hasConceptScore W2912031299C2780269544 @default.
• W2912031299 hasConceptScore W2912031299C2780564577 @default.
• W2912031299 hasConceptScore W2912031299C31849713 @default.

• next