FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912040129> ?p ?o ?g. }

• W2912040129 endingPage "556" @default.
• W2912040129 startingPage "549" @default.
• W2912040129 abstract "Metabolites obtained from the marine microorganisms were known for their important role in microbial inhibition. Interestingly, bioprospecting of secondary metabolites from marine derived actinomycetes has huge demand especially in the treatment of multi drug resistant clinical pathogens. The present study subjected towards the identification of promising antimicrobial actinomycetes from the Arabian Gulf regions and metabolic profiling of the crude organic solvent extract by chromatographic techniques.The strains were characterized by 16S rRNA sequencing. Extracellular metabolites were profiled by performing GC-MS analysis. MIC values of the compounds were detected using broth dilution technique.A Gram positive, spore forming filamentous Streptomyces sp. Al-Dhabi-90 possessed good antibacterial activities against the drug resistant pathogens were confirmed by 16S rRNA gene sequencing. Further, the gas chromatography coupled with mass spectrum analysis data revealed that the organic solvent extract of the fermented Streptomyces sp. Al-Dhabi-90 contained major components such as 3-methylpyridazine, n-hexadecanoic acid, indazol-4-one, octadecanoic acid and 3a-methyl-6-((4-methylphenyl) sul respectively. The Minimum Inhibitory Concentration (MIC) of the extract against Staphylococcus aureus and Klebsiella pneumoniae were 12.5 and 50μg/ml respectively. Against drug resistant ESBL pathogens such as Escherichia coli, Pseudomonsa aeroginosa and Proteus mirabilis were 12.5, and 25μg/ml respectively. Interestingly, the extract showed promising activity against the vancomycin resistant Enterococcus faecium at 50μg/ml. The increased level of cellular constituents after the extract treatment evidenced that the metabolites altered the membrane integrity of the pathogens.Conclusively, the marine Streptomyces sp. Al-Dhabi-90 is an ideal source for the treatment of multi drug resistant clinical pathogens." @default.
• W2912040129 created "2019-02-21" @default.
• W2912040129 creator A5040980180 @default.
• W2912040129 creator A5048361930 @default.
• W2912040129 creator A5050206301 @default.
• W2912040129 creator A5056131342 @default.
• W2912040129 creator A5081275310 @default.
• W2912040129 creator A5083177226 @default.
• W2912040129 date "2019-07-01" @default.
• W2912040129 modified "2023-10-16" @default.
• W2912040129 title "Bioactivity assessment of the Saudi Arabian Marine Streptomyces sp. Al-Dhabi-90, metabolic profiling and its in vitro inhibitory property against multidrug resistant and extended-spectrum beta-lactamase clinical bacterial pathogens" @default.
• W2912040129 cites W1552237914 @default.
• W2912040129 cites W1827350562 @default.
• W2912040129 cites W1963506577 @default.
• W2912040129 cites W1971565097 @default.
• W2912040129 cites W1972194308 @default.
• W2912040129 cites W1982017897 @default.
• W2912040129 cites W1998014770 @default.
• W2912040129 cites W2010846929 @default.
• W2912040129 cites W2014105764 @default.
• W2912040129 cites W2018662604 @default.
• W2912040129 cites W2023927534 @default.
• W2912040129 cites W2026588475 @default.
• W2912040129 cites W2083201626 @default.
• W2912040129 cites W2083299478 @default.
• W2912040129 cites W2091729115 @default.
• W2912040129 cites W2095293916 @default.
• W2912040129 cites W2117960631 @default.
• W2912040129 cites W2127431120 @default.
• W2912040129 cites W2170362744 @default.
• W2912040129 cites W2256742438 @default.
• W2912040129 cites W2491687103 @default.
• W2912040129 cites W2531682732 @default.
• W2912040129 cites W2534292362 @default.
• W2912040129 cites W2538285669 @default.
• W2912040129 cites W2619375984 @default.
• W2912040129 cites W2750928186 @default.
• W2912040129 cites W2772278838 @default.
• W2912040129 cites W2800938022 @default.
• W2912040129 cites W2890045018 @default.
• W2912040129 cites W2902368000 @default.
• W2912040129 cites W2903982181 @default.
• W2912040129 cites W2949178661 @default.
• W2912040129 cites W4211024023 @default.
• W2912040129 cites W4211082868 @default.
• W2912040129 doi "https://doi.org/10.1016/j.jiph.2019.01.065" @default.
• W2912040129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755364" @default.
• W2912040129 hasPublicationYear "2019" @default.
• W2912040129 type Work @default.
• W2912040129 sameAs 2912040129 @default.
• W2912040129 citedByCount "46" @default.
• W2912040129 countsByYear W29120401292019 @default.
• W2912040129 countsByYear W29120401292020 @default.
• W2912040129 countsByYear W29120401292021 @default.
• W2912040129 countsByYear W29120401292022 @default.
• W2912040129 countsByYear W29120401292023 @default.
• W2912040129 crossrefType "journal-article" @default.
• W2912040129 hasAuthorship W2912040129A5040980180 @default.
• W2912040129 hasAuthorship W2912040129A5048361930 @default.
• W2912040129 hasAuthorship W2912040129A5050206301 @default.
• W2912040129 hasAuthorship W2912040129A5056131342 @default.
• W2912040129 hasAuthorship W2912040129A5081275310 @default.
• W2912040129 hasAuthorship W2912040129A5083177226 @default.
• W2912040129 hasBestOaLocation W29120401291 @default.
• W2912040129 hasConcept C114851261 @default.
• W2912040129 hasConcept C133936738 @default.
• W2912040129 hasConcept C176947019 @default.
• W2912040129 hasConcept C185592680 @default.
• W2912040129 hasConcept C2777677444 @default.
• W2912040129 hasConcept C2778039505 @default.
• W2912040129 hasConcept C2779489039 @default.
• W2912040129 hasConcept C2779920670 @default.
• W2912040129 hasConcept C42062724 @default.
• W2912040129 hasConcept C4937899 @default.
• W2912040129 hasConcept C501593827 @default.
• W2912040129 hasConcept C523546767 @default.
• W2912040129 hasConcept C54355233 @default.
• W2912040129 hasConcept C86803240 @default.
• W2912040129 hasConcept C89423630 @default.
• W2912040129 hasConceptScore W2912040129C114851261 @default.
• W2912040129 hasConceptScore W2912040129C133936738 @default.
• W2912040129 hasConceptScore W2912040129C176947019 @default.
• W2912040129 hasConceptScore W2912040129C185592680 @default.
• W2912040129 hasConceptScore W2912040129C2777677444 @default.
• W2912040129 hasConceptScore W2912040129C2778039505 @default.
• W2912040129 hasConceptScore W2912040129C2779489039 @default.
• W2912040129 hasConceptScore W2912040129C2779920670 @default.
• W2912040129 hasConceptScore W2912040129C42062724 @default.
• W2912040129 hasConceptScore W2912040129C4937899 @default.
• W2912040129 hasConceptScore W2912040129C501593827 @default.
• W2912040129 hasConceptScore W2912040129C523546767 @default.
• W2912040129 hasConceptScore W2912040129C54355233 @default.
• W2912040129 hasConceptScore W2912040129C86803240 @default.
• W2912040129 hasConceptScore W2912040129C89423630 @default.
• W2912040129 hasFunder F4320321145 @default.
• W2912040129 hasIssue "4" @default.
• W2912040129 hasLocation W29120401291 @default.
• W2912040129 hasLocation W29120401292 @default.

• next