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- W2912041845 abstract "Introduction: Despite the availability of multiple pharmaceutical and targeted biological drugs for treatment of rheumatoid arthritis (RA), many patients exhibit intolerability or inadequate clinical response. Modulating innate anti-inflammatory neuro-immune pathways through electrical stimulation of the vagus nerve may represent a novel, nonpharmacological means of treating RA and other immune-mediated inflammatory diseases. We recently reported a 12-week proof-of-concept study with an implanted neuromodulation device, showing reduction in the DAS28-CRP disease activity score, with concomitant reductions in TNF - α and IL-6 levels (Proc Natl Acad Sci USA, 2016. 113(29):p.8284). To understand the long term safety and efficacy of this innovative treatment approach, we followed the subjects for 24 months in a long-term extension study." @default.
- W2912041845 created "2019-02-21" @default.
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- W2912041845 date "2019-03-01" @default.
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- W2912041845 title "Abstract #58: First-in-Class Neuromodulation Therapy in Subjects with Rheumatoid Arthritis: Two-Year Safety and Efficacy" @default.
- W2912041845 doi "https://doi.org/10.1016/j.brs.2018.12.065" @default.
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