FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912043948> ?p ?o ?g. }

• W2912043948 endingPage "808" @default.
• W2912043948 startingPage "800" @default.
• W2912043948 abstract "Dysembryoplastic neuroepithelial tumors (DNETs) are uncommon neural tumors presenting most often in children and young adults and associated with intractable seizures. Rare midline neoplasms with similar histological features to those found in DNETs have been described near the septum pellucidum and termed DNET-like neoplasms of the septum pellucidum. Due to their rarity, these tumors have been described in just a few reports and their genetic alterations sought only in small series.We collected 20 of these tumors for a comprehensive study of their clinical, radiological, and pathological features. RNA sequencing or targeted DNA sequencing was undertaken on 18 tumors, and genome-wide DNA methylation profiling was possible with 11 tumors. Published cases (n = 22) were also reviewed for comparative purposes.The commonest presenting symptoms and signs were related to raised intracranial pressure; 40% of cases required cerebrospinal fluid diversion. Epilepsy was seen in approximately one third of cases. All patients had an indolent disease course, despite metastasis within the neuraxis in a few cases. Radiologically, the septum verum/septal nuclei were involved in all cases and are the proposed site of origin for septal DNET (sDNET). Septal DNET showed a high frequency (~80%) of mutations of platelet derived growth factor receptor A (PDGFRA), and alterations in fibroblast growth factor receptor 1 (FGFR1) and neurofibromatosis type 1 (NF1) were also identified. In a genomic DNA methylation analysis alongside other neural tumors, sDNETs formed a separate molecular group.Genetic alterations that are different from those of cerebral DNETs and a distinct methylome profile support the proposal that sDNET is a distinct disease entity." @default.
• W2912043948 created "2019-02-21" @default.
• W2912043948 creator A5001366267 @default.
• W2912043948 creator A5003753493 @default.
• W2912043948 creator A5010113401 @default.
• W2912043948 creator A5010479652 @default.
• W2912043948 creator A5017152503 @default.
• W2912043948 creator A5023831997 @default.
• W2912043948 creator A5025835073 @default.
• W2912043948 creator A5027704793 @default.
• W2912043948 creator A5032932081 @default.
• W2912043948 creator A5036558579 @default.
• W2912043948 creator A5042510936 @default.
• W2912043948 creator A5046084065 @default.
• W2912043948 creator A5048616795 @default.
• W2912043948 creator A5052303124 @default.
• W2912043948 creator A5054727722 @default.
• W2912043948 creator A5054783478 @default.
• W2912043948 creator A5056114972 @default.
• W2912043948 creator A5057241613 @default.
• W2912043948 creator A5059921916 @default.
• W2912043948 creator A5060159232 @default.
• W2912043948 creator A5062818708 @default.
• W2912043948 creator A5071632296 @default.
• W2912043948 creator A5072519825 @default.
• W2912043948 creator A5082020327 @default.
• W2912043948 creator A5088250208 @default.
• W2912043948 date "2019-02-06" @default.
• W2912043948 modified "2023-10-15" @default.
• W2912043948 title "Septal dysembryoplastic neuroepithelial tumor: a comprehensive clinical, imaging, histopathologic, and molecular analysis" @default.
• W2912043948 cites W1983512588 @default.
• W2912043948 cites W2000629056 @default.
• W2912043948 cites W2010622342 @default.
• W2912043948 cites W2018194594 @default.
• W2912043948 cites W2037487701 @default.
• W2912043948 cites W2048192034 @default.
• W2912043948 cites W2062106022 @default.
• W2912043948 cites W2074929134 @default.
• W2912043948 cites W2077448071 @default.
• W2912043948 cites W2081218590 @default.
• W2912043948 cites W2101870168 @default.
• W2912043948 cites W2107318366 @default.
• W2912043948 cites W2115078134 @default.
• W2912043948 cites W2115462905 @default.
• W2912043948 cites W2263522623 @default.
• W2912043948 cites W2321158992 @default.
• W2912043948 cites W2327019527 @default.
• W2912043948 cites W2417562430 @default.
• W2912043948 cites W2790219659 @default.
• W2912043948 doi "https://doi.org/10.1093/neuonc/noz037" @default.
• W2912043948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6556860" @default.
• W2912043948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30726976" @default.
• W2912043948 hasPublicationYear "2019" @default.
• W2912043948 type Work @default.
• W2912043948 sameAs 2912043948 @default.
• W2912043948 citedByCount "34" @default.
• W2912043948 countsByYear W29120439482019 @default.
• W2912043948 countsByYear W29120439482020 @default.
• W2912043948 countsByYear W29120439482021 @default.
• W2912043948 countsByYear W29120439482022 @default.
• W2912043948 countsByYear W29120439482023 @default.
• W2912043948 crossrefType "journal-article" @default.
• W2912043948 hasAuthorship W2912043948A5001366267 @default.
• W2912043948 hasAuthorship W2912043948A5003753493 @default.
• W2912043948 hasAuthorship W2912043948A5010113401 @default.
• W2912043948 hasAuthorship W2912043948A5010479652 @default.
• W2912043948 hasAuthorship W2912043948A5017152503 @default.
• W2912043948 hasAuthorship W2912043948A5023831997 @default.
• W2912043948 hasAuthorship W2912043948A5025835073 @default.
• W2912043948 hasAuthorship W2912043948A5027704793 @default.
• W2912043948 hasAuthorship W2912043948A5032932081 @default.
• W2912043948 hasAuthorship W2912043948A5036558579 @default.
• W2912043948 hasAuthorship W2912043948A5042510936 @default.
• W2912043948 hasAuthorship W2912043948A5046084065 @default.
• W2912043948 hasAuthorship W2912043948A5048616795 @default.
• W2912043948 hasAuthorship W2912043948A5052303124 @default.
• W2912043948 hasAuthorship W2912043948A5054727722 @default.
• W2912043948 hasAuthorship W2912043948A5054783478 @default.
• W2912043948 hasAuthorship W2912043948A5056114972 @default.
• W2912043948 hasAuthorship W2912043948A5057241613 @default.
• W2912043948 hasAuthorship W2912043948A5059921916 @default.
• W2912043948 hasAuthorship W2912043948A5060159232 @default.
• W2912043948 hasAuthorship W2912043948A5062818708 @default.
• W2912043948 hasAuthorship W2912043948A5071632296 @default.
• W2912043948 hasAuthorship W2912043948A5072519825 @default.
• W2912043948 hasAuthorship W2912043948A5082020327 @default.
• W2912043948 hasAuthorship W2912043948A5088250208 @default.
• W2912043948 hasBestOaLocation W29120439481 @default.
• W2912043948 hasConcept C104317684 @default.
• W2912043948 hasConcept C105702510 @default.
• W2912043948 hasConcept C142724271 @default.
• W2912043948 hasConcept C150194340 @default.
• W2912043948 hasConcept C16930146 @default.
• W2912043948 hasConcept C169760540 @default.
• W2912043948 hasConcept C190727270 @default.
• W2912043948 hasConcept C2775922572 @default.
• W2912043948 hasConcept C2776799924 @default.
• W2912043948 hasConcept C2778186239 @default.

• next