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- W2912044537 endingPage "428" @default.
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- W2912044537 abstract "Aim: A systematic review and network meta-analysis were conducted to evaluate the efficacy of pembrolizumab + pemetrexed + platinum relative to other regimens in metastatic nonsquamous non-small-cell lung cancer (NSq-NSCLC). Patients & methods: Eligible studies evaluated first-line regimens in NSq-NSCLC patients without known targetable mutations. Relative treatment effects were synthesized with random effects proportional hazards Bayesian network meta-analyses. Results: The hazard ratio (HR) for overall survival (OS) for pembrolizumab + pemetrexed + platinum was statistically significant over all platinum-doublet (HR range: 0.42–0.61), platinum-doublet + bevacizumab (HR range: 0.44–0.53) and platinum-doublet + atezolizumab regimens (HR range: 0.56–0.62). Additionally, pembrolizumab + pemetrexed + platinum numerically improved OS over atezolizumab + paclitaxel + carboplatin + bevacizumab (HR: 0.65; 95% credible interval: 0.43, 1.01). Pembrolizumab + pemetrexed + platinum had 95.6% probability of being the best treatment regimen for OS. Conclusion: Pembrolizumab + pemetrexed + platinum is likely the most efficacious first-line regimen for metastatic NSq-NSCLC." @default.
- W2912044537 created "2019-02-21" @default.
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- W2912044537 date "2019-04-01" @default.
- W2912044537 modified "2023-09-25" @default.
- W2912044537 title "Pembrolizumab plus chemotherapy for first-line treatment of metastatic nonsquamous non-small-cell lung cancer: a network meta-analysis" @default.
- W2912044537 cites W1492694109 @default.
- W2912044537 cites W1517538518 @default.
- W2912044537 cites W1964370859 @default.
- W2912044537 cites W1966561347 @default.
- W2912044537 cites W1966744236 @default.
- W2912044537 cites W1967385770 @default.
- W2912044537 cites W1971181039 @default.
- W2912044537 cites W1982967337 @default.
- W2912044537 cites W1983700723 @default.
- W2912044537 cites W1997878281 @default.
- W2912044537 cites W2003027813 @default.
- W2912044537 cites W2005947177 @default.
- W2912044537 cites W2012368323 @default.
- W2912044537 cites W2032604714 @default.
- W2912044537 cites W2037418758 @default.
- W2912044537 cites W2040253672 @default.
- W2912044537 cites W2040376006 @default.
- W2912044537 cites W2057707250 @default.
- W2912044537 cites W2060251426 @default.
- W2912044537 cites W2063490878 @default.
- W2912044537 cites W2069284538 @default.
- W2912044537 cites W2072673200 @default.
- W2912044537 cites W2078475819 @default.
- W2912044537 cites W2093157946 @default.
- W2912044537 cites W2098923148 @default.
- W2912044537 cites W2099725888 @default.
- W2912044537 cites W2100785570 @default.
- W2912044537 cites W2103557620 @default.
- W2912044537 cites W2104347254 @default.
- W2912044537 cites W2106664438 @default.
- W2912044537 cites W2113144077 @default.
- W2912044537 cites W2115330744 @default.
- W2912044537 cites W2135140316 @default.
- W2912044537 cites W2136403887 @default.
- W2912044537 cites W2144660856 @default.
- W2912044537 cites W2145835533 @default.
- W2912044537 cites W2148367564 @default.
- W2912044537 cites W2154320833 @default.
- W2912044537 cites W2156353875 @default.
- W2912044537 cites W2167329126 @default.
- W2912044537 cites W2167921436 @default.
- W2912044537 cites W2198093519 @default.
- W2912044537 cites W2228221433 @default.
- W2912044537 cites W2527351299 @default.
- W2912044537 cites W2527905628 @default.
- W2912044537 cites W2529904548 @default.
- W2912044537 cites W2547680646 @default.
- W2912044537 cites W2557730509 @default.
- W2912044537 cites W2567564314 @default.
- W2912044537 cites W2570157415 @default.
- W2912044537 cites W2580216659 @default.
- W2912044537 cites W2602831557 @default.
- W2912044537 cites W2635951006 @default.
- W2912044537 cites W2763520788 @default.
- W2912044537 cites W2763816349 @default.
- W2912044537 cites W2767255092 @default.
- W2912044537 cites W2767287110 @default.
- W2912044537 cites W2767664311 @default.
- W2912044537 cites W2767788691 @default.
- W2912044537 cites W2775677084 @default.
- W2912044537 cites W2796582438 @default.
- W2912044537 cites W2804957255 @default.
- W2912044537 cites W2805354595 @default.
- W2912044537 cites W2885286334 @default.
- W2912044537 cites W2890591279 @default.
- W2912044537 cites W2890663189 @default.
- W2912044537 cites W2896241567 @default.
- W2912044537 cites W2898172118 @default.
- W2912044537 cites W2898187558 @default.
- W2912044537 cites W2898484604 @default.
- W2912044537 cites W2898490299 @default.
- W2912044537 cites W4210992155 @default.
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- W2912044537 doi "https://doi.org/10.2217/imt-2018-0193" @default.
- W2912044537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712477" @default.
- W2912044537 hasPublicationYear "2019" @default.
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