FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912051662> ?p ?o ?g. }

• W2912051662 endingPage "e0007128" @default.
• W2912051662 startingPage "e0007128" @default.
• W2912051662 abstract "Background Early ante-mortem laboratory confirmation of human rabies is essential to aid patient management and institute public health measures. Few studies have highlighted the diagnostic value of antibody detection in CSF/serum in rabies, and its utility is usually undermined owing to the late seroconversion and short survival in infected patients. This study was undertaken to examine the ante-mortem diagnostic utility and prognostic value of antibody detection by rapid fluorescent focus inhibition test (RFFIT) in cerebrospinal fluid (CSF)/serum samples received from clinically suspected human rabies cases from January 2015 to December 2017. Methodology/Principal findings Samples collected ante-mortem and post-mortem from 130 and 6 patients with clinically suspected rabies respectively, were received in the laboratory during the study period. Ante-mortem laboratory confirmation was achieved in 55/130 (42.3%) cases. Real time PCR for detection of viral nucleic acid performed on saliva, nuchal skin, brain tissue and CSF samples could confirm the diagnosis in 15 (27.2%) of the 55 laboratory confirmed cases. Ante-mortem diagnosis could be achieved by RFFIT (in CSF and/or serum) in 45 (34.6%) of the 130 clinically suspected cases, accounting for 81.8% of the total 55 laboratory confirmed cases. The sensitivity of CSF RFFIT increased with the day of sample collection (post-onset of symptoms) and was found to be 100% after 12 days of illness. Patients who had received prior vaccination had an increased probability of a positive RFFIT and negative PCR result. Patients who were positive by RFFIT alone at initial diagnosis had longer survival (albeit with neurological sequelae) than patients who were positive by PCR alone or both RFFIT and PCR. Conclusions/Significance Detection of antibodies in the CSF/serum is a valuable ante-mortem diagnostic tool in human rabies, especially in patients who survive beyond a week. It was also found to have a limited role as a prognostic marker to predict outcomes in patients." @default.
• W2912051662 created "2019-02-21" @default.
• W2912051662 creator A5018770540 @default.
• W2912051662 creator A5037283054 @default.
• W2912051662 creator A5054142151 @default.
• W2912051662 date "2019-01-29" @default.
• W2912051662 modified "2023-10-12" @default.
• W2912051662 title "Utility of rabies neutralizing antibody detection in cerebrospinal fluid and serum for ante-mortem diagnosis of human rabies" @default.
• W2912051662 cites W1565520727 @default.
• W2912051662 cites W1626833456 @default.
• W2912051662 cites W1896017675 @default.
• W2912051662 cites W1995761937 @default.
• W2912051662 cites W2019507030 @default.
• W2912051662 cites W2021004670 @default.
• W2912051662 cites W2023431527 @default.
• W2912051662 cites W2035181468 @default.
• W2912051662 cites W2040409881 @default.
• W2912051662 cites W2053207708 @default.
• W2912051662 cites W2060139000 @default.
• W2912051662 cites W2071532188 @default.
• W2912051662 cites W2073034493 @default.
• W2912051662 cites W2078202100 @default.
• W2912051662 cites W2095285160 @default.
• W2912051662 cites W2104792597 @default.
• W2912051662 cites W2112282923 @default.
• W2912051662 cites W2118108549 @default.
• W2912051662 cites W2130637995 @default.
• W2912051662 cites W2154078982 @default.
• W2912051662 cites W2161235948 @default.
• W2912051662 cites W2239545017 @default.
• W2912051662 cites W2252497066 @default.
• W2912051662 cites W2486411439 @default.
• W2912051662 cites W2763379667 @default.
• W2912051662 cites W2788210051 @default.
• W2912051662 cites W2899520268 @default.
• W2912051662 cites W4211133799 @default.
• W2912051662 cites W2206290284 @default.
• W2912051662 doi "https://doi.org/10.1371/journal.pntd.0007128" @default.
• W2912051662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368332" @default.
• W2912051662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30695032" @default.
• W2912051662 hasPublicationYear "2019" @default.
• W2912051662 type Work @default.
• W2912051662 sameAs 2912051662 @default.
• W2912051662 citedByCount "18" @default.
• W2912051662 countsByYear W29120516622019 @default.
• W2912051662 countsByYear W29120516622020 @default.
• W2912051662 countsByYear W29120516622021 @default.
• W2912051662 countsByYear W29120516622022 @default.
• W2912051662 countsByYear W29120516622023 @default.
• W2912051662 crossrefType "journal-article" @default.
• W2912051662 hasAuthorship W2912051662A5018770540 @default.
• W2912051662 hasAuthorship W2912051662A5037283054 @default.
• W2912051662 hasAuthorship W2912051662A5054142151 @default.
• W2912051662 hasBestOaLocation W29120516621 @default.
• W2912051662 hasConcept C126322002 @default.
• W2912051662 hasConcept C159047783 @default.
• W2912051662 hasConcept C159654299 @default.
• W2912051662 hasConcept C203014093 @default.
• W2912051662 hasConcept C22070199 @default.
• W2912051662 hasConcept C2776849203 @default.
• W2912051662 hasConcept C2777451964 @default.
• W2912051662 hasConcept C2777961786 @default.
• W2912051662 hasConcept C71924100 @default.
• W2912051662 hasConceptScore W2912051662C126322002 @default.
• W2912051662 hasConceptScore W2912051662C159047783 @default.
• W2912051662 hasConceptScore W2912051662C159654299 @default.
• W2912051662 hasConceptScore W2912051662C203014093 @default.
• W2912051662 hasConceptScore W2912051662C22070199 @default.
• W2912051662 hasConceptScore W2912051662C2776849203 @default.
• W2912051662 hasConceptScore W2912051662C2777451964 @default.
• W2912051662 hasConceptScore W2912051662C2777961786 @default.
• W2912051662 hasConceptScore W2912051662C71924100 @default.
• W2912051662 hasIssue "1" @default.
• W2912051662 hasLocation W29120516621 @default.
• W2912051662 hasLocation W29120516622 @default.
• W2912051662 hasLocation W29120516623 @default.
• W2912051662 hasLocation W29120516624 @default.
• W2912051662 hasLocation W29120516625 @default.
• W2912051662 hasOpenAccess W2912051662 @default.
• W2912051662 hasPrimaryLocation W29120516621 @default.
• W2912051662 hasRelatedWork W1553932158 @default.
• W2912051662 hasRelatedWork W1972446104 @default.
• W2912051662 hasRelatedWork W2012165816 @default.
• W2912051662 hasRelatedWork W2041649802 @default.
• W2912051662 hasRelatedWork W2114422674 @default.
• W2912051662 hasRelatedWork W2348323180 @default.
• W2912051662 hasRelatedWork W2406876478 @default.
• W2912051662 hasRelatedWork W2885522869 @default.
• W2912051662 hasRelatedWork W755624206 @default.
• W2912051662 hasRelatedWork W2183587730 @default.
• W2912051662 hasVolume "13" @default.
• W2912051662 isParatext "false" @default.
• W2912051662 isRetracted "false" @default.
• W2912051662 magId "2912051662" @default.
• W2912051662 workType "article" @default.