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• W2912052286 endingPage "1476" @default.
• W2912052286 startingPage "1465" @default.
• W2912052286 abstract "Psoriasis has historically been considered a nonpruritic dermatosis, in contrast with atopic dermatitis. Thus, itch has often been underappreciated and overlooked in psoriasis. However, increasing evidence over the past decade has shown that itch can be one of the most prevalent and burdensome symptoms associated with psoriasis, affecting almost every patient to some degree. Itch can involve the entire body, although it predominantly affects the legs, hands, back, body and especially the scalp. Uncontrolled itch can significantly impact all aspects of the well-being and quality of life of the patient. While there has been some progress in trying to better understand the pathophysiology of itch in psoriasis, more research effort and interest are needed. This under-recognition of itch in psoriasis is clearly reflected in the dearth of treatment options targeting itch despite significant advancement in treating the lesions themselves. Recently, however, clinical studies have begun to include itch as a study outcome. The resulting data have demonstrated concomitant antipruritic benefits and improved Psoriasis Area and Severity Index (PASI) scores with mainstay treatments for psoriasis, such as topical corticosteroids and vitamin D analogs, phototherapies, and various systemics and biologics. This article takes a closer look at this debilitating symptom, reviewing the available epidemiology data for psoriatic itch, presenting the current understanding of psoriatic itch pathophysiology and highlighting important clinical data for various treatment options for itch. Practical considerations for increasing the recognition of itch as well as improving its management in psoriasis are also provided." @default.
• W2912052286 created "2019-02-21" @default.
• W2912052286 creator A5003122683 @default.
• W2912052286 creator A5025545596 @default.
• W2912052286 creator A5032105584 @default.
• W2912052286 creator A5038505651 @default.
• W2912052286 creator A5039040970 @default.
• W2912052286 creator A5048521405 @default.
• W2912052286 creator A5070890272 @default.
• W2912052286 date "2019-08-01" @default.
• W2912052286 modified "2023-10-06" @default.
• W2912052286 title "Itch: an under‐recognized problem in psoriasis" @default.
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