FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912052644> ?p ?o ?g. }

• W2912052644 endingPage "11" @default.
• W2912052644 startingPage "1" @default.
• W2912052644 abstract "Liver inflammation influences monocyte function, recruitment, and consequently inflammatory and fibrogenic responses. We aimed to investigate changes in the circulating monocyte phenotypes in response to Daclatasvir-Sofosbuvir (SOF/DCV) therapy in chronic hepatitis C (CHC) and relate findings to the viral kinetics and the fibrosis score.A longitudinal study involving 100 treatment-naïve patients and 30 healthy controls, tested for liver function, fibrosis scores (AST to platelet ratio index, FIB-4), and blood monocyte subsets based on CD14/CD16 expression by flow cytometer.CHC patients had significantly lower albumin, higher ALT, AST, alkaline phosphatase, and increased fibrosis scores [Fib-4 (1.85±0.98) and AST to platelet ratio index (APRI) (0.6±0.35)], higher monocyte and eosinophil counts and lowered neutrophil to monocyte ratio (NMR), and lymphocyte to monocyte ratio (LMR) compared to week 12 and control. CHC patients had significantly increased median [classical (52.2% versus 25.8%, P=0.004) and inflammatory CD16+ monocytes (23.1% versus 13.58%, P=0.035)]. Therapy results in achievement of sustained virological response in 92% of cases, liver function improvement, and normalization of the inflammatory monocytes subsets. Monocyte counts showed positive correlation with viral load, calculated fibrosis scores (APRI and FIB-4 score), AST, ALT, ANC, and inverse correlations with serum albumin, leukocyte, eosinophil, NMR, and LMR. Multivariate regression found eosinophil count as predictors of CD16+ monocyte count in CHC patients.CHC infection promotes a proinflammatory and profibrotic monocytes profile. SOF/DCV therapy efficiently decreases viral load, reduces fibrosis potentials, attenuates monocyte activation, normalizes monocytes phenotypic abnormalities, and modulates monocyte subsets recruitment and differentiation later in the liver." @default.
• W2912052644 created "2019-02-21" @default.
• W2912052644 creator A5028562603 @default.
• W2912052644 creator A5040321968 @default.
• W2912052644 creator A5080551489 @default.
• W2912052644 date "2019-02-03" @default.
• W2912052644 modified "2023-09-24" @default.
• W2912052644 title "Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study" @default.
• W2912052644 cites W1970136916 @default.
• W2912052644 cites W1983156180 @default.
• W2912052644 cites W1984378291 @default.
• W2912052644 cites W1987344938 @default.
• W2912052644 cites W1988201931 @default.
• W2912052644 cites W1991893044 @default.
• W2912052644 cites W1993406705 @default.
• W2912052644 cites W1997865776 @default.
• W2912052644 cites W1998156718 @default.
• W2912052644 cites W2009016013 @default.
• W2912052644 cites W2010472060 @default.
• W2912052644 cites W2012136117 @default.
• W2912052644 cites W2014275955 @default.
• W2912052644 cites W2038026702 @default.
• W2912052644 cites W2042132622 @default.
• W2912052644 cites W2048466125 @default.
• W2912052644 cites W2048511851 @default.
• W2912052644 cites W2051013988 @default.
• W2912052644 cites W2071276803 @default.
• W2912052644 cites W2078251659 @default.
• W2912052644 cites W2080625714 @default.
• W2912052644 cites W2085099489 @default.
• W2912052644 cites W2088337379 @default.
• W2912052644 cites W2099368337 @default.
• W2912052644 cites W2114799524 @default.
• W2912052644 cites W2119415849 @default.
• W2912052644 cites W2127845947 @default.
• W2912052644 cites W2149217958 @default.
• W2912052644 cites W2155177346 @default.
• W2912052644 cites W2156965164 @default.
• W2912052644 cites W2157268533 @default.
• W2912052644 cites W2228540040 @default.
• W2912052644 cites W2268066121 @default.
• W2912052644 cites W2291256337 @default.
• W2912052644 cites W2613752459 @default.
• W2912052644 cites W305511679 @default.
• W2912052644 doi "https://doi.org/10.1155/2019/9469567" @default.
• W2912052644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6420991" @default.
• W2912052644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30941170" @default.
• W2912052644 hasPublicationYear "2019" @default.
• W2912052644 type Work @default.
• W2912052644 sameAs 2912052644 @default.
• W2912052644 citedByCount "2" @default.
• W2912052644 countsByYear W29120526442020 @default.
• W2912052644 countsByYear W29120526442023 @default.
• W2912052644 crossrefType "journal-article" @default.
• W2912052644 hasAuthorship W2912052644A5028562603 @default.
• W2912052644 hasAuthorship W2912052644A5040321968 @default.
• W2912052644 hasAuthorship W2912052644A5080551489 @default.
• W2912052644 hasBestOaLocation W29120526441 @default.
• W2912052644 hasConcept C126322002 @default.
• W2912052644 hasConcept C170493617 @default.
• W2912052644 hasConcept C203014093 @default.
• W2912052644 hasConcept C2522874641 @default.
• W2912052644 hasConcept C2776042228 @default.
• W2912052644 hasConcept C2776408679 @default.
• W2912052644 hasConcept C2776979040 @default.
• W2912052644 hasConcept C2777037409 @default.
• W2912052644 hasConcept C2778390639 @default.
• W2912052644 hasConcept C2778513237 @default.
• W2912052644 hasConcept C2780040827 @default.
• W2912052644 hasConcept C2780559512 @default.
• W2912052644 hasConcept C2781184567 @default.
• W2912052644 hasConcept C71924100 @default.
• W2912052644 hasConcept C90924648 @default.
• W2912052644 hasConceptScore W2912052644C126322002 @default.
• W2912052644 hasConceptScore W2912052644C170493617 @default.
• W2912052644 hasConceptScore W2912052644C203014093 @default.
• W2912052644 hasConceptScore W2912052644C2522874641 @default.
• W2912052644 hasConceptScore W2912052644C2776042228 @default.
• W2912052644 hasConceptScore W2912052644C2776408679 @default.
• W2912052644 hasConceptScore W2912052644C2776979040 @default.
• W2912052644 hasConceptScore W2912052644C2777037409 @default.
• W2912052644 hasConceptScore W2912052644C2778390639 @default.
• W2912052644 hasConceptScore W2912052644C2778513237 @default.
• W2912052644 hasConceptScore W2912052644C2780040827 @default.
• W2912052644 hasConceptScore W2912052644C2780559512 @default.
• W2912052644 hasConceptScore W2912052644C2781184567 @default.
• W2912052644 hasConceptScore W2912052644C71924100 @default.
• W2912052644 hasConceptScore W2912052644C90924648 @default.
• W2912052644 hasLocation W29120526441 @default.
• W2912052644 hasLocation W29120526442 @default.
• W2912052644 hasLocation W29120526443 @default.
• W2912052644 hasLocation W29120526444 @default.
• W2912052644 hasOpenAccess W2912052644 @default.
• W2912052644 hasPrimaryLocation W29120526441 @default.
• W2912052644 hasRelatedWork W1565880338 @default.
• W2912052644 hasRelatedWork W1584774122 @default.
• W2912052644 hasRelatedWork W1975953426 @default.
• W2912052644 hasRelatedWork W1999929128 @default.

• next